{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:12:27Z","timestamp":1771297947991,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,8,26]]},"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To report the clinicopathological characteristics of patients with ocular adnexal marginal zone B cell lymphoma (MZBL) with IgG4-positive plasma cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>114 biopsy samples of ocular adnexal MZBLs were analysed. MZBLs with IgG4-positive plasma cells were included when the IgG4:IgG ratio was &gt;40% (IgG4-related group). The serum levels of each subclass of immunoglobulins and soluble interleukin-2 receptor in the IgG4-related group were compared with those in 61 consecutive patients having MZBL without IgG4-positive plasma cells (IgG4-unrelated group). They were also compared with those in 10 patients having ocular adnexal IgG4-related lymphoplasmacytic disorder (IgG4-related inflammatory group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten (9%) of the patients were diagnosed with MZBL with IgG4-positive plasma cells. The IgG4-related group had a significantly greater degree of sclerosis and reactive follicles in the MZBLs (p=0.0004 and p=0.01, respectively). The serum levels of IgG, IgG1, IgG4, IgE and soluble interleukin 2 receptor in the IgG4-related group were significantly higher than those in the IgG4-unrelated group (p=0.003, p=0.009, p&lt;0.0001, p&lt;0.0001 and p=0.0007, respectively). The serum levels did not differ significantly from those of the IgG4-related inflammatory group. The IgG4-related group also had reactive IgG4-positive lymphoplasmacytic infiltrations in the recurrent lesion and in the stomach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IgG4-positive plasma cells had infiltrated into ocular adnexal MZBLs in 9% of cases. It is suggested that ocular adnexal MZBLs with IgG4-positive plasma cells have unique histological and serological characteristics that overlap those of ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder and systemic conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2010.082156","type":"journal-article","created":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T23:20:42Z","timestamp":1288221642000},"page":"1059-1065","source":"Crossref","is-referenced-by-count":67,"title":["Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells"],"prefix":"10.1136","volume":"63","author":[{"given":"Toshinobu","family":"Kubota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuko","family":"Moritani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Terasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,10,27]]},"reference":[{"key":"2025120519080443000_63.12.1059.1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213350.49767.46"},{"key":"2025120519080443000_63.12.1059.2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.45"},{"key":"2025120519080443000_63.12.1059.3","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31816148ad"},{"key":"2025120519080443000_63.12.1059.4","first-page":"1860","article-title":"Report of the Committee on Hodgkin's Disease Staging Classification","volume":"31","author":"Carbone","year":"1971","journal-title":"Cancer Res"},{"key":"2025120519080443000_63.12.1059.5","doi-asserted-by":"crossref","unstructured":"Coupland SE White V Rootman J . TNM staging of ocular adnexal lymphomas. In: Edge SB Fritz AG Byrd DR , eds. AJCC Cancer Staging Manual. 7th edn. New York, NY: Springer, 2009:583\u20139.","DOI":"10.1007\/978-0-387-88441-7_55"},{"key":"2025120519080443000_63.12.1059.6","unstructured":"Swerdlow SH Campo E Harris NL . WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. Lyon, France: International Agency for Research on Cancer, 2008."},{"key":"2025120519080443000_63.12.1059.7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"2025120519080443000_63.12.1059.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.01.006"},{"key":"2025120519080443000_63.12.1059.9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2285"},{"key":"2025120519080443000_63.12.1059.10","doi-asserted-by":"crossref","unstructured":"Platts-Millis TA . Immediate hypersensitivity (Type I). In: Male D Brostoff J Roth DB Roitt I , eds. Immunology. 7th edn. Philadelphia: Elsevier, 2006:423\u201348.","DOI":"10.1016\/B0-323-03399-7\/50025-8"},{"key":"2025120519080443000_63.12.1059.11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-8-619"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2010.082156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:08:16Z","timestamp":1764990496000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2010.082156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,27]]},"references-count":11,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,11,19]]},"published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1136\/jcp.2010.082156"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2010.082156","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,27]]}}}