{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T01:56:43Z","timestamp":1794621403100,"version":"4.9.1"},"reference-count":14,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,8,12]]},"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pure mucinous breast carcinoma (PMBC) is uncommon and associated with better prognosis than mixed mucinous breast carcinoma (MMBC). A micropapillary pattern in PMBC has been identified although its prognostic significance is questionable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of 100 cases of mucinous carcinoma diagnosed between 2000 and 2009 was conducted. Two broad categories were studied: PMBC (more than 90% mucinous component; n=45) and MMBC (less than 90% mucinous component; n=55). PMBC was further subclassified as hypocellular\/type A (n=37) and cellular\/type B (n=8). Receptor status, clinicomorphological and prognostic features were compared without patient follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean age at diagnosis in PMBC and MMBC was 60 and 63\u2005years, while mean tumour size was 1.65 and 2.5 cm, respectively. Mean age in type A and type B PMBC patients was 75 and 55\u2005years, respectively. The majority of PMBCs were well differentiated, with two poorly differentiated cases as well. The majority of MMBCs were moderately differentiated. A micropapillary pattern was seen in 20% of PMBCs. Sentinel lymph nodes were positive in 18.5% of PMBCs and 16% of MMBCs. Non-sentinel lymph nodes were positive in 14% of PMBCs and 39% of MMBCs. A micropapillary pattern was seen in 60% of LN positive PMBCs and 14% of LN negative PMBCs. Furthermore, 95% of PMBCs were ER(+), 84% were PR(+) and 9% were Her-2(+); 91% of MMBCs were ER(+), 87% were PR(+) and 33% were Her-2(+).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PMBCs with a micropapillary pattern were more frequently associated with nodal disease. PMBCs with axillary disease had one or more of the following: micropapillary pattern, high nuclear grade, Her-2 positivity, smaller tumour size or younger age. Hence, axillary staging by sentinel lymph node biopsy is recommended in PMBCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2010.082495","type":"journal-article","created":{"date-parts":[[2010,10,20]],"date-time":"2010-10-20T22:21:01Z","timestamp":1287613261000},"page":"1043-1047","source":"Crossref","is-referenced-by-count":81,"title":["Clinicopathological evaluation of 100 cases of mucinous carcinoma of breast with emphasis on axillary staging and special reference to a micropapillary pattern"],"prefix":"10.1136","volume":"63","author":[{"given":"Aditi","family":"Ranade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagangeet","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit A","family":"Chitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasminka","family":"Balderacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,10,20]]},"reference":[{"key":"2025121219575792000_63.12.1043.1","unstructured":"Rosen PP . Mucinous carcinoma. In: Rosen PP , ed. Rosen's breast pathology, 3rd edn. Philadelphia, PA: Lippincott-Williams & Wilkins, 2009:515."},{"key":"2025121219575792000_63.12.1043.2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.24988"},{"key":"2025121219575792000_63.12.1043.3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jso.2930580305","article-title":"Mucinous carcinoma of the breast: a pathologic study of 82 cases","volume":"58","author":"Andr\u00c3\u00a9","year":"1995","journal-title":"J Surg Oncol"},{"key":"2025121219575792000_63.12.1043.4","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90069-5"},{"key":"2025121219575792000_63.12.1043.5","unstructured":"Rosen PP . Mucinous carcinoma. In: Rosen PP , ed. Rosen's breast pathology, 3rd edn. Philadelphia, PA: Lippincott-Williams & Wilkins, 2009:519."},{"key":"2025121219575792000_63.12.1043.6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/jso.2930280204","article-title":"Breast carcinoma at the extremes of age: a comparison of patients younger than 35\u00e2\u0080\u0085years and older than 75\u00e2\u0080\u0085years","volume":"28","author":"Rosen","year":"1985","journal-title":"J Surg Oncol"},{"key":"2025121219575792000_63.12.1043.7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0046-8177(86)80152-6","article-title":"Pure mucinous carcinomas of breast: morphologic features and prognostic correlates","volume":"17","author":"Clayton","year":"1986","journal-title":"Hum Pathol"},{"key":"2025121219575792000_63.12.1043.8","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2001.1142"},{"key":"2025121219575792000_63.12.1043.9","doi-asserted-by":"publisher","DOI":"10.1177\/1066896908314784"},{"key":"2025121219575792000_63.12.1043.10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10747"},{"key":"2025121219575792000_63.12.1043.11","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9809-z"},{"key":"2025121219575792000_63.12.1043.12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/00015458.2009.11680406","article-title":"Do clinical and immunohistochemical findings of pure mucinous breast carcinoma differ from mixed mucinous breast carcinoma?","volume":"109","author":"Erhan","year":"2009","journal-title":"Acta Chir Belg"},{"key":"2025121219575792000_63.12.1043.13","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2002.9.2.161"},{"key":"2025121219575792000_63.12.1043.14","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1200\/JCO.1999.17.5.1442","article-title":"Tumor characteristics and clinical outcome of tubular and mucinous breast carcinomas","volume":"17","author":"Diab","year":"1999","journal-title":"J Clin Oncol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2010.082495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:58:07Z","timestamp":1765598287000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2010.082495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,20]]},"references-count":14,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,11,19]]},"published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1136\/jcp.2010.082495"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2010.082495","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,20]]}}}