{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:38:41Z","timestamp":1777037921408,"version":"3.51.4"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,10,25]]},"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>15\u201330% of cases of cervical intraepithelial neoplasia grades 2\u20133 (CIN2\u20133) detected in punch biopsies regress spontaneously (ie, show CIN1 or less in the follow-up cone). Epithelial retinoblastoma protein (pRb), tumour suppressor protein (p53), HPV genotype and immunoreactive cells have been reported to be helpful in predicting regression but their interaction in regression prediction is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>55 cases of CIN2\u20133 in cervical biopsies with subsequent cervical cones were studied retrospectively to assess how epithelial biomarkers, immunoreactive cells (with immunohistochemistry) and high-risk (hr) HPV genotypes (by the AMPLICOR and linear array tests) prognostically interact with epithelial pRb and p53.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      18% of CIN2\u20133s regressed (median biopsy\u2013cone interval of 12.0\u2005weeks, range 5.0\u201334.1\u2005weeks). CIN2\u20133s that regressed had higher epithelial pRb and p53, lower stromal CD25\n                      <jats:sup>+<\/jats:sup>\n                      and CD138\n                      <jats:sup>+<\/jats:sup>\n                      , and higher CD8 cells than persistent lesions. They also had higher ratios of CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD25\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      \/CD25 in stroma and epithelium. HPV16 correlated with low pRb and low CD8\n                      <jats:sup>+<\/jats:sup>\n                      . With multivariate analysis a combined high ratio of CD8\n                      <jats:sup>+<\/jats:sup>\n                      \/CD25\n                      <jats:sup>+<\/jats:sup>\n                      in the stroma, high epithelial pRb and p53 expression had independent value to predict the regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      CIN2\u20133 lesions with a non-hrHPV16 infection, high ratios of stromal CD8\n                      <jats:sup>+<\/jats:sup>\n                      \/CD25\n                      <jats:sup>+<\/jats:sup>\n                      and high epithelial expression of pRb or p53 are associated with spontaneous regression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2010.083626","type":"journal-article","created":{"date-parts":[[2011,3,18]],"date-time":"2011-03-18T09:13:30Z","timestamp":1300439610000},"page":"303-307","source":"Crossref","is-referenced-by-count":38,"title":["The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2\u20133"],"prefix":"10.1136","volume":"64","author":[{"given":"Irene Tveiter\u00e5s","family":"\u00d8vestad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar","family":"Gudlaugsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivar","family":"Skaland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anais","family":"Malpica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ane Cecilie","family":"Munk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiel A M","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan P","family":"Baak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,3,18]]},"reference":[{"key":"2025120519531426000_64.4.303.1","unstructured":"Horner MJRL Krapcho M Neyman N . SEER Cancer Statistics Review, 1975\u00e2\u0080\u00932006. Bethesda, MD: National Cancer Institute, 2009. http:\/\/seer.cancer.gov\/csr\/1975_2006\/based on November 2008 SEER data submission, posted to the SEER web site."},{"key":"2025120519531426000_64.4.303.2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00004347-199304000-00018","article-title":"The natural history of cervical intraepithelial neoplasia: a critical review","volume":"12","author":"Ostor","year":"1993","journal-title":"Int J Gynecol Pathol"},{"key":"2025120519531426000_64.4.303.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70103-7"},{"key":"2025120519531426000_64.4.303.4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-119"},{"key":"2025120519531426000_64.4.303.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1343"},{"key":"2025120519531426000_64.4.303.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1284"},{"key":"2025120519531426000_64.4.303.7","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.10.833"},{"key":"2025120519531426000_64.4.303.8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200211000-00013"},{"key":"2025120519531426000_64.4.303.9","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.027839"},{"key":"2025120519531426000_64.4.303.10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.109"},{"key":"2025120519531426000_64.4.303.11","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-0124"},{"key":"2025120519531426000_64.4.303.12","doi-asserted-by":"publisher","DOI":"10.1002\/path.1480"},{"key":"2025120519531426000_64.4.303.13","first-page":"13","article-title":"Ki67 predicts progression in early CIN: validation of a multivariate progression-risk model","volume":"26","author":"Kruse","year":"2004","journal-title":"Cell Oncol"},{"key":"2025120519531426000_64.4.303.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.10.005"},{"key":"2025120519531426000_64.4.303.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.08.014"},{"key":"2025120519531426000_64.4.303.16","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.061010"},{"key":"2025120519531426000_64.4.303.17","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800723"},{"key":"2025120519531426000_64.4.303.18","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800223"},{"key":"2025120519531426000_64.4.303.19","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0846"},{"key":"2025120519531426000_64.4.303.20","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.19.10566-10574.2003"},{"key":"2025120519531426000_64.4.303.21","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1101\/gad.11.16.2090","article-title":"Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein","volume":"11","author":"Funk","year":"1997","journal-title":"Genes Dev"},{"key":"2025120519531426000_64.4.303.22","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90409-8"},{"key":"2025120519531426000_64.4.303.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.12.016"},{"key":"2025120519531426000_64.4.303.24","doi-asserted-by":"publisher","DOI":"10.2174\/1874357900903010067"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2010.083626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:53:24Z","timestamp":1764993204000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2010.083626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,18]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,3,18]]},"published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1136\/jcp.2010.083626"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2010.083626","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,18]]}}}