{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:26:30Z","timestamp":1758792390104,"version":"3.44.0"},"reference-count":33,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,10,4]]},"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Peripheral T cell lymphoma not otherwise specified (PTCL\/NOS) is the commonest PTCL subtype. Recently, proliferation pathways have been found to be commonly altered in PTCL\/NOS. <jats:italic>CDKN1B<\/jats:italic>\/p27, a critical regulator of cell cycle and proliferation, has been suggested to be involved in T cell lymphomagenesis. This study aimed to evaluate the possible occurrence of <jats:italic>CDKN1B<\/jats:italic>\/p27 aberrations in PTCL\/NOS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>\n                     <jats:italic>CDKN1B<\/jats:italic>\/p27 expression at RNA and protein level by DNA and tissue microarrays, in 28 and 98 cases, respectively, was studied. Additionally, direct sequencing of <jats:italic>CDKN1B<\/jats:italic> in 81 PTCL\/NOS was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                     <jats:italic>CDKN1B<\/jats:italic> mRNA was similarly expressed in PTCL\/NOS and normal T lymphocytes. In addition, structural abnormalities were not found; these included mutations and deletions in any exons, exon\u2013intron junctions or regulatory regions. Furthermore, physiological expression of p27 in neoplastic cells was demonstrated by immunohistochemistry; this was mutually exclusive with Ki-67, as expected when the system is intact. Consistently, the expression of other molecules that are functionally related to <jats:italic>CDKN1B\/<\/jats:italic>p27 in controlling cell cycle (including <jats:italic>CCNE1<\/jats:italic>) did not appear to be affected at either the mRNA or protein level. Finally, it was found that p27 expression was not significantly related with overall survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>\n                     <jats:italic>CDKN1B<\/jats:italic>\/p27 aberrations seem to be uncommon in PTCL\/NOS pathogenesis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2010.083832","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T23:39:37Z","timestamp":1288741177000},"page":"83-87","source":"Crossref","is-referenced-by-count":2,"title":["<i>CDKN1B\/<\/i>p27 expression in peripheral T cell lymphoma not otherwise specified"],"prefix":"10.1136","volume":"64","author":[{"given":"Anna","family":"Gazzola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Sista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Agostinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Righi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosaria","family":"Sapienza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Mannu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sabattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Went","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Luigi","family":"Zinzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano A","family":"Pileri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Paolo","family":"Piccaluga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,11,2]]},"reference":[{"key":"2025092501282861000_64.1.83.1","unstructured":"Pileri S Ralfkiaer E Weisenburger D . Peripheral T-cell lymphoma, not otherwise specified. In: Swerdlow S Campo E Harris NL , eds. WHO classification of tumors of hematopoietic and lymphoid tissues. 4th edn. 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