{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:33:17Z","timestamp":1765600397914,"version":"3.48.0"},"reference-count":29,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,12,17]]},"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Fine needle aspiration cytology (FNAC) of radiologically abnormal axillary lymph nodes in patients with breast cancer can identify patients suitable for primary axillary clearance (AC) rather than sentinel node biopsy, enabling surgical axillary staging by a single operation. This study assessed the accuracy of FNAC in predicting positive axillary lymph nodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>161 patients with screen-detected invasive carcinoma and who had pre-operative FNAC of a radiologically abnormal axillary lymph node were identified from two screening units, The axillary FNAC reports were correlated with sentinel node biopsy and AC reports, and sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FNAC had a moderate sensitivity (66.3%) and NPV (71.8%), and a high specificity (98.7%) and PPV (98.3%). Most patients (86%) had a single axillary operation. The sensitivity was highest in grade 3 (81.8%) and ductal type (77.8%) tumours. The sensitivity was lower in tumours of special type (34.8%), grade 1 tumours (50%) and those without lymphovascular invasion (LVI) (55.9%). The NPV was highest in pT1 (86.7%) and in grade 1 (84.5%) tumours, and lowest (44%) in tumours with LVI. The PPV was 100% in grade 1 and 3 tumours, stage pT2 and pT3 tumours and those without LVI, and was high (&gt;96%) in all other groups. In lymph-node-positive patients, the mean number of lymph nodes involved was higher in the case of a positive (6.4) than negative FNAC (4.4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FNAC of ultrasonically abnormal axillary lymph nodes achieved surgical staging by a single operation in most patients with screen-detected invasive breast carcinoma, with moderate sensitivity and high specificity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2010.084772","type":"journal-article","created":{"date-parts":[[2011,1,22]],"date-time":"2011-01-22T20:46:17Z","timestamp":1295729177000},"page":"338-342","source":"Crossref","is-referenced-by-count":13,"title":["Axillary fine needle aspiration cytology for pre-operative staging of patients with screen-detected invasive breast carcinoma"],"prefix":"10.1136","volume":"64","author":[{"given":"Brian D","family":"Hayes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Feeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecily M","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"O'Doherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fidelma","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Marie","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,1,22]]},"reference":[{"key":"2025121220314242000_64.4.338.1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831101)52:9<1551::AID-CNCR2820520902>3.0.CO;2-3"},{"key":"2025121220314242000_64.4.338.2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.7863\/jum.1989.8.3.115","article-title":"Real-time ultrasound, axillary mammography, and clinical examination in the diagnosis of axillary lymph node metastases in breast cancer patients","volume":"8","author":"Pamilo","year":"1989","journal-title":"J Ultrasound Med"},{"key":"2025121220314242000_64.4.338.3","first-page":"139","article-title":"Ultrasound detection of axillary lymph node metastases in breast cancer","volume":"15","author":"Tate","year":"1989","journal-title":"Eur J Surg Oncol"},{"key":"2025121220314242000_64.4.338.4","first-page":"15","article-title":"Ultrasonographic detection of metastatic axillary lymphnodes in breast cancer","volume":"79","author":"Mustonen","year":"1990","journal-title":"Ann Chir Gynaecol"},{"key":"2025121220314242000_64.4.338.5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21568"},{"key":"2025121220314242000_64.4.338.6","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9593-3"},{"key":"2025121220314242000_64.4.338.7","doi-asserted-by":"crossref","unstructured":"Lorand S Lavou\u00e9 V Tas P . 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