{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:46:00Z","timestamp":1792788360719,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2011,1,5]]},"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Osteoprotegerin (OPG) and receptor activator of nuclear factor \u03ba B ligand (RANKL) play a critical role in the regulation of bone turnover, but the relative importance of these two cytokines in the pathogenesis of postmenopausal osteoporosis is controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To investigate the relationship between circulating levels of OPG, RANKL, bone turnover and bone mineral density (BMD) in postmenopausal women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross-sectional study of 185 women with osteoporosis and 185 age- and sex-matched control subjects was undertaken. Measurements were made of plasma OPG, RANKL, interleukin-6 (IL-6), sex steroids, calciotropic hormones, biochemical markers of bone turnover, BMD and anthropometry. Health questionnaires were administered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Plasma RANKL was significantly higher (p&lt;0.0001) in women with osteoporosis (0.66\u00b10.67\u2005pmol\/l) than in control subjects (0.37\u00b10.38\u2005pmol\/l), as was plasma OPG (18.70\u00b19.70\u2005pmol\/l in women with osteoporosis, 10.44\u00b15.85\u2005pmol\/l in control subjects; p&lt;0.0001). OPG\/RANKL ratio was higher in women with osteoporosis (51.3) than in control subjects (36.6). The women with osteoporosis also had significantly higher biochemical markers of bone turnover, IL-6 and parathyroid hormone and lower 25-hydroxyvitamin D and oestradiol than the control subjects. Multiple regression analysis showed that lumbar spine and femoral neck BMD in postmenopausal women were best predicted by OPG and RANKL, giving an R<jats:sup>2<\/jats:sup> value of 15.5% and 14.9%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study indicates that the circulating levels of OPG and RANKL are inversely related to BMD and contribute to the development of osteoporosis in postmenopausal women.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2010.086595","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T21:57:55Z","timestamp":1297288675000},"page":"354-357","source":"Crossref","is-referenced-by-count":91,"title":["Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis"],"prefix":"10.1136","volume":"64","author":[{"given":"Suhair","family":"Jabbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Drury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N","family":"Fordham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish K","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger M","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P","family":"Tuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,2,9]]},"reference":[{"key":"2025092502083377000_64.4.354.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90218-E"},{"key":"2025092502083377000_64.4.354.2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00614-7"},{"key":"2025092502083377000_64.4.354.3","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-008-0027-3"},{"key":"2025092502083377000_64.4.354.4","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2006.056622"},{"key":"2025092502083377000_64.4.354.5","unstructured":"Russell RG . Pathogenesis of Osteoporosis. In: Hochberg MC Silman AJ Smolen SJ , eds. Rheumatology. 3rd edn. New York: Mosby, 2003:2075\u2013147."},{"key":"2025092502083377000_64.4.354.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-2039-5"},{"key":"2025092502083377000_64.4.354.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2005.00242.x"},{"key":"2025092502083377000_64.4.354.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00108-008-2113-0"},{"key":"2025092502083377000_64.4.354.9","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.048868"},{"key":"2025092502083377000_64.4.354.10","first-page":"889","article-title":"Osteoclastogenesis and bone resorption","volume":"67","author":"Nakamura","year":"2009","journal-title":"Nippon Rinsho"},{"key":"2025092502083377000_64.4.354.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2008.04.005"},{"key":"2025092502083377000_64.4.354.12","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-89520-8_9"},{"key":"2025092502083377000_64.4.354.13","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1359\/jbmr.040113","article-title":"Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: new pieces of the puzzle","volume":"19","author":"Morabito","year":"2004","journal-title":"J Bone Miner Res"},{"key":"2025092502083377000_64.4.354.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1844-1"},{"key":"2025092502083377000_64.4.354.15","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-004-0074-4"},{"key":"2025092502083377000_64.4.354.16","doi-asserted-by":"publisher","DOI":"10.1007\/s10195-005-0087-4"},{"key":"2025092502083377000_64.4.354.17","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-06-0753"},{"key":"2025092502083377000_64.4.354.18","doi-asserted-by":"publisher","DOI":"10.1159\/000196280"},{"key":"2025092502083377000_64.4.354.19","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181a181b8"},{"key":"2025092502083377000_64.4.354.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-004-0007-2"},{"key":"2025092502083377000_64.4.354.21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01317.x"},{"key":"2025092502083377000_64.4.354.22","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.2.359"},{"key":"2025092502083377000_64.4.354.23","first-page":"31625","article-title":"Osteoprotegerin plasma levels in men: correlation with age, estrogen and testosterone status","volume":"86","author":"Szulc","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2025092502083377000_64.4.354.24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.2.631"},{"key":"2025092502083377000_64.4.354.25","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1699-x"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2010.086595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:08:59Z","timestamp":1758791339000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2010.086595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,9]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,3,18]]},"published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1136\/jcp.2010.086595"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2010.086595","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,9]]}}}