{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:50:08Z","timestamp":1783698608065,"version":"3.55.0"},"reference-count":17,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2011,5,22]]},"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is known that syndecan 1 in inflammatory bowel diseases is able to migrate from epithelial basolateral site to the stromal area and apical surface of epithelium with a consequent activation and modulation of basic fibroblast growth factor (bFGF), and this process sustains mucosal healing of ulcers. On the other hand, tumour necrosis factor (TNF) \u03b1 mucosal levels are directly related to the entity of the damage in these disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim of the study<\/jats:title>\n                    <jats:p>A \u2018post-hoc\u2019 retrospective study was performed to estimate mucosal TNF \u03b1 in rectal biopsies of subjects with ulcerative colitis (UC) before and after effective infliximab therapy and its relationship with syndecan 1, bFGF and endoscopic mucosal healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Paraffin-embedded rectal samples from 12 patients with UC responders to infliximab were analysed for TNF \u03b1, syndecan 1 and bFGF before and 6\u2005months after therapy using a real-time reverse transcriptase polymersase chain reaction. Additionally, syndecan 1 location was evaluated by immunohistochemistry. Samples from 12 subjects with irritable bowel symptoms without endoscopic\/histological abnormalities represented the control group. Mucosal healing induced by the treatment was defined by an endoscopic Mayo subscore changing from 2\u20133 to 0. ANOVA plus Student\u2013Newman\u2013Keuls was used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The authors found that in the active disease, an increase in TNF \u03b1 (p&lt;0.001) is accompanied by raised levels of both syndecan 1 (p&lt;0.005) and bFGF (p&lt;0.005) compared with the control group. Infliximab-induced TNF \u03b1 decrease to levels similar to controls is associated with both endoscopic mucosal healing and adhesion molecule\/growth factor significant reduction. Additionally, syndecan 1 location, which is predominant in the stromal cells and apical epithelium in the active disorder, is quite exclusively located at the basolateral epithelial area in both healed mucosa and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Balanced interaction among TNF \u03b1 inhibition by infliximab, syndecan 1 migration, bFGF repair modulation and final adhesion molecule reversal to its normal location might represent a suitable molecular pathway of endoscopic mucosal healing in UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2010.086892","type":"journal-article","created":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T20:15:55Z","timestamp":1316808955000},"page":"968-972","source":"Crossref","is-referenced-by-count":9,"title":["Infliximab therapy downregulation of basic fibroblast growth factor\/syndecan 1 link: a 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