{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:29:03Z","timestamp":1768249743979,"version":"3.49.0"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1968,5]]},"abstract":"<jats:p>Zinc is an essential trace element. Previous methods of measuring zinc in clinical material have been difficult and reported findings must be treated with caution. Using atomic absorption spectroscopy it has been established that plasma zinc is one of the most uniform biochemical characteristics of normal adult blood. Sex and age differences in adult life are insignificant. Increased metabolic activity, on the other hand, induces a marked, immediate fall in plasma zinc level. The possible implications of this are discussed. Zinc levels in patients with diabetes mellitus, cardiovascular disease, and anaemia due to acute blood loss have been within normal limits. Plasma zinc is low in certain types of liver disease.<\/jats:p>","DOI":"10.1136\/jcp.21.3.359","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"359-363","source":"Crossref","is-referenced-by-count":207,"title":["Measurements of plasma zinc"],"prefix":"10.1136","volume":"21","author":[{"given":"I. J. T.","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Musa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. L.","family":"Dormandy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1968,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1042\/bj0341163","volume":"34","author":"Keilin, D.; Mann, T.","year":"1940","unstructured":"Keilin, D., and Mann, T. (1940). Biochem. J., 34, 1163.","journal-title":"Biochem. J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0021-9258(19)77351-7","volume":"233","author":"Mathies, J.C.","year":"1958","unstructured":"Mathies, J. C. (1958). J. biol. Chem., 233, 1121.","journal-title":"J. biol. Chem"},{"key":"ref_3","first-page":"121","volume":"1","author":"Pories, W.L.; Henzel, J.H.; Rob, C.G.; Strain, W.H.","year":"1967","unstructured":"Pories, W. L., Henzel, J. H., Rob, C. G., and Strain, W. H. (1967). Lancet, 1, 121.","journal-title":"Lancet"},{"key":"ref_4","first-page":"537","volume":"61","author":"Prasad, A.S.; Miale, Jr., A.; Faid, Z.; Sandstead, H.H.; Schulert, A.R.","year":"1963","unstructured":"Prasad, A. S., Miale, A., Jr., Faid, Z., Sandstead, H. H., and Schulert, A. R. (1963). J. Lab. clin. Med., 61, 537.","journal-title":"J. Lab. clin. Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/ajcn\/17.1.15","volume":"17","author":"Hifney, A.; Mokhtar, N.; Darby, W.J.","year":"1965","unstructured":"Hifney, A., Mokhtar, N., and Darby, W. J. (1965). Amer. J. clin. Nutr., 17, 15.","journal-title":"Amer. J. clin. Nutr"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0022-4804(62)80065-1","volume":"2","author":"Savlov, E.D.; Strain, W.H.; Huegin, F.","year":"1962","unstructured":"Savlov, E. D., Strain, W. H., and Huegin, F. (1962). J. surg. Res., 2, 209.","journal-title":"J. surg. Res"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3181\/00379727-88-21670","volume":"88","author":"Tucker, H.F.; Salmon, W.D.","year":"1955","unstructured":"Tucker, H. F., and Salmon, W. D. (1955). Proc. Soc. exp. Biol. (N. Y.), 88, 613.","journal-title":"Proc. Soc. exp. Biol. (N. Y.)"},{"key":"ref_8","article-title":"Trace Elements in Human and Animal Nutrition","author":"Underwood, E.J.","year":"1962","unstructured":"Underwood, E. J. (1962). Trace Elements in Human and Animal Nutrition. Academic Press, New York and London."},{"issue":"435","key":"ref_9","volume":"176","author":"Vallee, B.L.; Gibson, II, J.G.","year":"1948","unstructured":"Vallee, B. L., and Gibson, J. G., II (1948). J. biol. Chem., 176,435 and 445.","journal-title":"J. biol. Chem"},{"key":"ref_10","first-page":"619","volume":"15","author":"Vallee, B.L.; Gibson, II, J.G.; Hoch, F.L.","year":"1956","unstructured":"Vallee, B. L., and Gibson, J. G., II, and Hoch, F. L. (1956). Fed. Proc., 15, 619.","journal-title":"Fed. Proc"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1056\/NEJM195711282572201","volume":"257","author":"Wacker, W.E.C.; Bortholomay, A.F.; Hoch, F.L.","year":"1957","unstructured":"Wacker, W. E. C., Bortholomay, A. F., and Hoch, F. L. (1957). New Engl. J. Med., 257, 1055.","journal-title":"New Engl. J. Med"},{"key":"ref_12","first-page":"403","volume":"255","author":"Robin, E.D.","year":"1956","unstructured":", - 1,and Robin, E. D. (1956). Ibid., 255, 403.","journal-title":"Ibid"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/00365515009051850","volume":"2","author":"Vikbladh, I.","year":"1950","unstructured":"Vikbladh, I. (1950). Scand. J. clin. Lab. Invest., 2, 143.","journal-title":"Scand. J. clin. Lab. Invest"},{"issue":"2","key":"ref_14","first-page":"16","volume":"3","author":"Vikbladh, I.","year":"1951","unstructured":"Vikbladh, I. (1951). Ibid., 3, suppl. 2, 16.","journal-title":"Ibid"},{"key":"ref_15","first-page":"1","volume":"11","author":"Willis, J.B.","year":"1963","unstructured":"Willis, J. B. (1963). Meth. biochem. Anal., 11, 1.","journal-title":"Meth. biochem. Anal"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/184742a0","volume":"184","author":"Winder, F.; Denneny, J.M.","year":"1959","unstructured":"Winder, F., and Denneny, J. M. (1959). Nature (Lond.), 184, 742.","journal-title":"Nature (Lond.)"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2423(08)60372-8","volume":"7","author":"Zettner, A.","year":"1964","unstructured":"Zettner, A. (1964). Advanc. clin. Chem., 7, 1.","journal-title":"Advanc. clin. Chem"},{"key":"ref_18","article-title":"Studies on the relation between zinc and malignant disease are numerous but, on the whole, desultory and inconclusive. Low zinc concentrations have been reported in leukaemic cells compared to normal white blood cells","volume-title":"1961); 65Zn studies suggest that the zinc turnover rate in malignant prostatic tissue is considerably slower than in the normal","author":"(Prout, Sierp, and Whitmore, 1959; Hoare, Delory, and Penner,","year":"1959","unstructured":"Studies on the relation between zinc and malignant disease are numerous but, on the whole, desultory and inconclusive. Low zinc concentrations have been reported in leukaemic cells compared to normal white blood cells (Gibson, Vallee, Fluharty, and Nelson, 1950; Dennes, Tupper, and Wormall, 1961); 65Zn studies suggest that the zinc turnover rate in malignant prostatic tissue is considerably slower than in the normal gland (Prout, Sierp, and Whitmore, 1959; Hoare, Delory, and Penner, 1956), and whole blood zinc was depressed in most of the 31 patients with carcinoma investigated by Addink and Frank (1959). On the other hand, high zinc concentrations have been reported in some experimentally induced tumours (Cristol, 1927). The present study was prompted by the unexpected finding of extremely low plasma zinc levels in some patients with carcinoma of the bronchus.","edition":"gland"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.21.3.359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:15:23Z","timestamp":1765077323000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.21.3.359"}},"subtitle":["Part I In health and disease"],"short-title":[],"issued":{"date-parts":[[1968,5]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1968,5,1]]},"published-print":{"date-parts":[[1968,5]]}},"alternative-id":["10.1136\/jcp.21.3.359"],"URL":"https:\/\/doi.org\/10.1136\/jcp.21.3.359","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,5]]}}}