{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:03:35Z","timestamp":1765728215201,"version":"3.48.0"},"reference-count":5,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1969,3]]},"abstract":"<jats:p>\n                    The conditions described by Hoffbrand, Newcombe, and Mollin (1966) for the estimation of red cell folate activity have been confirmed using a different method (Spray, 1964) of micro-biological assay with\n                    <jats:italic>Lactobacillus casei.<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>In 81 control subjects the levels of folate activity in the red cells were between 80 and 470 m\u03bcg\/ml (mean 192), and in plasma between 2\u00b71 and 13 m\u03bcg\/ml (mean 4\u00b79). In 16 patients with megaloblastic anaemia due to folic acid deficiency, the red cell folate level was between 3 and 74 m\u03bcg\/ml (mean 32). In 15 of these patients the plasma level was between 0\u00b71 and 1\u00b70 m\u03bcg\/ml; in the other patient it was 3\u00b73 m\u03bcg\/ml. Subnormal red cell levels were found in only eight out of 29 other patients whose plasma folate level was below 2\u00b70 m\u03bcg\/ml. In 26 patients with untreated pernicious anaemia, the red cell folate activity was between 44 and 280 m\u03bcg\/ml (mean 129) and the plasma level was between 1\u00b76 and 19 m\u03bcg\/ml (mean 7\u00b75).<\/jats:p>","DOI":"10.1136\/jcp.22.2.212","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"212-216","source":"Crossref","is-referenced-by-count":11,"title":["Estimation of red cell folate activity"],"prefix":"10.1136","volume":"22","author":[{"given":"G. H.","family":"Spray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/jcp.19.1.17","volume":"19","author":"Hoffbrand, A.V.; Newcombe, B.F.A.; Mollin, D.L.","year":"1966","unstructured":"Hoffbrand, A. V., Newcombe, B. F. A., and Mollin, D. L. (1966). J. clin. Path., 19, 17.","journal-title":"J. clin. Path"},{"key":"ref_2","first-page":"661","volume":"14","author":"Spray, G.H.","year":"1955","unstructured":"Spray, G. H. (1955). Clin. Sci., 14, 661.","journal-title":"Clin. Sci"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/jcp.17.6.660","volume":"17","author":"Spray, G.H.","year":"1964","unstructured":"Spray, G. H. (1964). J. clin. Path., 17, 660.","journal-title":"J. clin. Path"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0021-9258(18)65199-3","volume":"221","author":"Toennies, G.; Usdin, E.; Phillips, P.M.","year":"1956","unstructured":"Toennies, G., Usdin, E., and Phillips, P. M. (1956). J. biol. Chem., 221, 855.","journal-title":"J. biol. Chem"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1136\/jcp.14.4.335","volume":"14","author":"Waters, A.H.; Mollin, D.L.","year":"1961","unstructured":"Waters, A. H., and Mollin, D. L. (1961). J. clin. Path., 14, 335.","journal-title":"J. clin. Path"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.22.2.212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:59:58Z","timestamp":1765727998000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.22.2.212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,3]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1969,3,1]]},"published-print":{"date-parts":[[1969,3]]}},"alternative-id":["10.1136\/jcp.22.2.212"],"URL":"https:\/\/doi.org\/10.1136\/jcp.22.2.212","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1969,3]]}}}