{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:48:01Z","timestamp":1758804481635,"version":"3.44.0"},"reference-count":37,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1969,11]]},"abstract":"<jats:p>Of 119 neonates dying after 48 hours of life, 19 (16%) showed disseminated fibrin thromboembolism, a histological condition that is very similar to one form of maternal hypofibrinogenaemia. The incidence is nearly five times that among stillbirths and neonates dying within 48 hours of birth.<\/jats:p>\n               <jats:p>Most of the mothers had a normal pregnancy, labour, and puerperium. One twin may show the condition while the other survives. It is suggested that the affected infants have either no fibrinolytic mechanism, a defective one, or one which for some unaccountable reason was not brought into action. The antecedent plasma fibrinogen level is likely to have been high in some cases, but a fatal outcome can ensue with normal or low levels. The process was considered to be totally responsible for death in six cases (5%) of the series. Renal tubular hyaline droplets apparently rich in haemoglobin were only encountered in one infant (no. 4) who died from massive bilateral adrenal haemorrhage.<\/jats:p>\n               <jats:p>In the later part of the neonatal period, the process is liable to be indistinguishable clinically from secondary thrombotic processes, which occurred with almost the same incidence in the present series (14(12%) of 119 cases).<\/jats:p>","DOI":"10.1136\/jcp.22.6.663","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"663-671","source":"Crossref","is-referenced-by-count":11,"title":["Disseminated fibrin thromboembolism among neonates dying more than 48 hours after birth"],"prefix":"10.1136","volume":"22","author":[{"given":"J. F.","family":"Boyd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,11,1]]},"reference":[{"key":"ref_1","volume":"vol.","author":"Barcroft, J.","year":"1946","unstructured":"Barcroft, J. (1946). Researches on Prenatal Life, vol. I Blackwell, Oxford.","journal-title":"Researches on Prenatal Life"},{"key":"ref_2","first-page":"176","volume":"106","author":"Boyd, J.F.","year":"1958","unstructured":"Boyd, J. F. (1958). Surg. Gynec. Obstet., 106, 176.","journal-title":"Surg. Gynec. Obstet"},{"key":"ref_3","series-title":"J. Path. Bact","first-page":"53","article-title":"Antemortem thrombosis in stillbirths, neonates, infants and children, with particular reference to disseminated fibrin thrombo-embolism","volume":"90","author":"Boyd, J.F.","year":"1960","unstructured":"Boyd, J. F. (1960). Antemortem thrombosis in stillbirths, neonates, infants and children, with particular reference to disseminated fibrin thrombo-embolism. D.M. Thesis, Glasgow University. (1965). J. Path. Bact., 90, 53. -(1%96). J. Obstet. Gynaec. Brit. Cwlth, 73, 629."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/adc.42.224.401","volume":"42","author":"Boyd, J.F.","year":"1967","unstructured":"Boyd, J. F. (1967). Arch. Dis. Childh., 42, 401.","journal-title":"Arch. Dis. Childh"},{"key":"ref_5","first-page":"90","volume":"1","author":"Brain, M.C.; Bull, B.S.; Dacie, J.V.; Regoeczi, E.; Rubenberg, M.L.","year":"1968","unstructured":"Brain, M. C., Bull, B. S., Dacie, J. V., Regoeczi, E., and Rubenberg, M. L. (1968). Lancet, 1, 90.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/ajcp\/50.2.211","volume":"50","author":"Brodsky, I.; Meyer, A.N.; Kahn, S.B.; Ross, E.M.","year":"1968","unstructured":"Brodsky, I., Meyer, A. N., Kahn, S. B., and Ross, E. M. (1968). Amer. J. clin. Path., 50, 211.","journal-title":"Amer. J. clin. Path"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/jcp.20.6.854","volume":"20","author":"Bryant, S.J.","year":"1967","unstructured":"Bryant, S. J. (1967). J. clin. Path., 20, 854.","journal-title":"J. clin. Path"},{"key":"ref_8","first-page":"1123","volume":"2","author":"Bull, B.S.; Rubenberg, M.L.; Dacie, J.V.; Brain, M.C.","year":"1967","unstructured":"Bull, B. S., Rubenberg, M. L., Dacie, J. V., and Brain, M. C. (1967). Lancet, 2, 1123.","journal-title":"Lancet"},{"key":"ref_9","article-title":"Perinatal Mortality. The First Report of the 1958 British Perinatal Mortality Survey","author":"Butler, N.R.; Bonham, D.G.","year":"1963","unstructured":"Butler, N. R., and Bonham, D. G. (1963). Perinatal Mortality. The First Report of the 1958 British Perinatal Mortality Survey. Livingstone, Edinburgh and London."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/path.1700540113","volume":"54","author":"Bywaters, E.G.L.; Dible, J.H.","year":"1942","unstructured":"Bywaters, E. G. L., and Dible, J. H. (1942). J. Path. Bact., 54, 111.","journal-title":"J. Path. Bact"},{"key":"ref_11","volume-title":"Changes in the circulation at birth and the effects of asphyxia. In Recent Advances in Paediatrics","author":"Dawes, G.","year":"1958","unstructured":"Dawes, G. (1958). Changes in the circulation at birth and the effects of asphyxia. In Recent Advances in Paediatrics, edited by D. Gairdner, 2nd ed. Churchill, London.","edition":"2nd ed"},{"key":"ref_12","first-page":"545","volume":"1","year":"1968","unstructured":"Gray, 0. P., Ackerman, A., and Fraser, A. J. (1968). Lancet, 1, 545.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/00365516609087210","volume":"18","author":"Jacobsen, C.D.","year":"1966","unstructured":"Jacobsen, C. D. (1966). Scand. J. clin. Lab. Invest., 18, 359.","journal-title":"Scand. J. clin. Lab. Invest"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/003693305600101105","volume":"1","author":"Johnstone, J.M.; McCallum, H.M.","year":"1956","unstructured":"Johnstone, J. M., and McCallum, H. M. (1956). Scot. med. J., 1, 360.","journal-title":"Scot. med. J"},{"key":"ref_15","article-title":"Progress Report to Caledonian Branch of the Association of Clinical Pathologists","author":"Lendrum, A.C.","year":"1957","unstructured":"Lendrum, A. C. (1957). Progress Report to Caledonian Branch of the Association of Clinical Pathologists."},{"key":"ref_16","first-page":"559","volume":"45","author":"Lieb, E.","year":"1948","unstructured":"Lieb, E. (1948). Arch. Path., 45, 559.","journal-title":"Arch. Path"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2141.1967.tb00762.x","volume":"13","author":"Merskey, C.; Johnson, A.J.; Kleiner, G.J.; Wohl, H.","year":"1967","unstructured":"Merskey, C., Johnson, A. J., Kleiner, G. J., and Wohl, H. (1967). Brit. J. Haemat., 13, 528.","journal-title":"Brit. J. Haemat"},{"key":"ref_18","first-page":"517","article-title":"Histochemistry. Theoretical and Applied","volume":"652","author":"Pearse, A.G.E.","year":"1961","unstructured":"Pearse, A. G. E. (1961). Histochemistry. Theoretical and Applied, 2nd ed., pp. 517, 652, 903 and 904. Churchill, London.","edition":"2nd ed"},{"issue":"601","key":"ref_19","volume":"1","author":"Regoeczi, E.; Rubenberg, M.L.; Brain, M.C.","year":"1967","unstructured":"Regoeczi, E., Rubenberg, M. L., and Brain, M. C. (1967). Lancet, 1,601.","journal-title":"Lancet"},{"key":"ref_20","first-page":"36","volume":"85","author":"Rosen, S.; Hano, J.E.; Barry, K.G.","year":"1968","unstructured":"Rosen, S., Hano, J. E., and Barry, K. G. (1968). Arch. Path., 85, 36.","journal-title":"Arch. Path"},{"key":"ref_21","first-page":"1121","volume":"2","author":"Rubenberg, M.L.; Bull, B.S.; Regoeczi, E.; Dacie, J.V.; Brain, M.C.","year":"1967","unstructured":"Rubenberg, M. L., Bull, B. S., Regoeczi, E., Dacie, J. V., and Brain, M. C. (1967). Lancet, 2, 1121.","journal-title":"Lancet"},{"issue":"569","key":"ref_22","volume":"91","author":"Sanerkin, N.G.; Edwards, P.; Jacobs, J.","year":"1966","unstructured":"Sanerkin, N. G., Edwards, P., and Jacobs, J. (1966). J. Path. Bact., 91,569.","journal-title":"J. Path. Bact"},{"issue":"269","key":"ref_23","volume":"90","author":"Sanerkin, N.G.; Edwards, P.; Jacobs, J.; Evans, D.M.D.","year":"1965","unstructured":"Sanerkin, N. G., Edwards, P., and Jacobs, J. and Evans, D. M. D. (1965). Ibid., 90,269.","journal-title":"Ibid"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/adc.40.212.426","volume":"40","author":"Scott, J.M.","year":"1965","unstructured":"Scott, J. M. (1965). Arch. Dis. Childh., 40, 426.","journal-title":"Arch. Dis. Childh"},{"key":"ref_25","first-page":"1081","volume":"2","author":"Timbury, M.C.; Wilson, T.S.; Hutchison, J.G.P.; Govan, A.D.T.","year":"1958","unstructured":"Timbury, M. C., Wilson, T. S., Hutchison, J. G. P., and Govan, A. D. T. (1958). Lancet, 2, 1081.","journal-title":"Lancet"},{"issue":"1085","key":"ref_26","volume":"2","author":"Wehinger, H.; Kunzer, W.","year":"1968","unstructured":"Wehinger, H., and Kunzer, W. (1968). Ibid., 2,1085.","journal-title":"Ibid"},{"key":"ref_27","first-page":"2","volume":"81","author":"Zuelzer, W.W.; Kurnetz, R.; Charles, S.","year":"1951","unstructured":"Zuelzer, W. W., Kurnetz, R., and Charles, S. (1951). Amer. J. Dis. Childh., 81, 2.","journal-title":"Amer. J. Dis. Childh"},{"key":"ref_28","article-title":"Reports and Bulletins prepared by the Association of Clinical Biochemists The following reports and bulletins are published by the Association of Clinical Biochemists. They may be obtained from The Administrative Office, Association of","volume":"7","author":"Court, Warwick; Holborn, London; W.","unstructured":"Reports and Bulletins prepared by the Association of Clinical Biochemists The following reports and bulletins are published by the Association of Clinical Biochemists. They may be obtained from The Administrative Office, Association of Clinical Biochemists, 7 Warwick Court, Holborn, London, W.C.1. The prices include postage, but airmail will be charged extra. Overseas readers should remit by British Postal or Money Order. If this is not possible, the equivalent of 10s. is the minimum amount that can be accepted.","journal-title":"Clinical Biochemists; C.1. The prices include postage, but airmail will be charged extra. Overseas readers should remit by British Postal or Money Order"},{"key":"ref_29","article-title":"Automatic Dispensing Pipettes. An assessment of 35 commercial instruments","volume":"1","author":"BROUGHTON, P.M.G.; GOWENLOCK, A.H.; WIDDOWSON, G.M.; A, K.","year":"1967","unstructured":"Automatic Dispensing Pipettes. An assessment of 35 commercial instruments. 1967. P. M. G. BROUGHTON, A. H. GOWENLOCK, G. M. WIDDOWSON, and K. A. AHLQUIST. 1Os.","journal-title":"AHLQUIST"},{"key":"ref_30","first-page":"6","volume":"2","author":"G, P.M.","year":"1968","unstructured":"Control Solutions for Clinical Biochemistry. February 1968. P. M. G. BROUGHTON. 2s. 6d.","journal-title":"BROUGHTON"},{"key":"ref_31","article-title":"An Assessment of the Technicon Type II Sampler Unit","volume":"6","author":"GRAY, 1968. B. C.; is, G. K. MCGOWAN.","year":"March","unstructured":"An Assessment of the Technicon Type II Sampler Unit. March 1968. B. C. GRAY and G. K. MCGOWAN. is. 6d."},{"key":"ref_32","article-title":"Determination of Urea by AutoAnalyzer. November 1966. RUTH M. HASLAM. 2s. 6d. 14 Atomic Absorption Spectroscopy. An Outline of its Principles and a Guide to the Selection of Instruments","volume":"4","author":"DAWSON, J.B.","year":"1968","unstructured":"Determination of Urea by AutoAnalyzer. November 1966. RUTH M. HASLAM. 2s. 6d. 14 Atomic Absorption Spectroscopy. An Outline of its Principles and a Guide to the Selection of Instruments. May 1968. J. B. DAWSON and P. M. G. BROUGHTON. 4s."},{"key":"ref_33","article-title":"A comparative list of 14 instruments","volume-title":"HANNELORE BRAUNSBERG. (Reissued in response to demand. Text still valuable, list now out of date.) 5s","author":"Fluorimeters, Filter","year":"1967","unstructured":"Filter Fluorimeters. A comparative list of 14 instruments. March 1967. HANNELORE BRAUNSBERG. (Reissued in response to demand. Text still valuable, list now out of date.) 5s."},{"key":"ref_34","first-page":"6","volume":"2","author":"of Serum Albumin by AutoAnalyzer using Bromocresol Green, Determination","year":"1967","unstructured":"Determination of Serum Albumin by AutoAnalyzer using Bromocresol Green. October 1967. B. E. NORTHAM and G. M. WIDDOWSON. 2s. 6d."},{"key":"ref_35","article-title":"A Guide to Automatic Pipettes","volume":"5","author":"G, P.M.","year":"1968","unstructured":"A Guide to Automatic Pipettes (2nd edition). June 1968. P. M. G. BROUGHTON. 5s.","edition":"2nd edition","journal-title":"BROUGHTON"},{"key":"ref_36","first-page":"6","article-title":"A Guide to Automation in Clinical Chemistry","volume":"12","author":"G, 1969. P. M.","year":"May","unstructured":"A Guide to Automation in Clinical Chemistry. May 1969. P. M. G. BROUGHTON 12s. 6d. ($1.50).","journal-title":"BROUGHTON"},{"key":"ref_37","unstructured":"Flame Photometers (2nd edition). 1969. P. WILDING. 12s. 6d. ($1.50).","article-title":"Flame Photometers"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.22.6.663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:16:12Z","timestamp":1758802572000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.22.6.663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,11]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1969,11,1]]},"published-print":{"date-parts":[[1969,11]]}},"alternative-id":["10.1136\/jcp.22.6.663"],"URL":"https:\/\/doi.org\/10.1136\/jcp.22.6.663","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1969,11]]}}}