{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:04:35Z","timestamp":1784192675295,"version":"3.55.0"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1970,2]]},"abstract":"<jats:p>Five cases of fatal generalized herpes simplex infection in malnourished children are described. This is almost certainly a much more common disease in underdeveloped communities than is at present appreciated. Only a greater awareness of the disease, coupled with full use of histological and cultural methods of diagnosis, will lead to knowledge of its true frequency.<\/jats:p>\n                  <jats:p>A case of neonatal infection, the first recorded in an African, is also described. Reasons are suggested as to why this disease should be seen in malnourished infants in Africa but only very rarely in neonates.<\/jats:p>","DOI":"10.1136\/jcp.23.1.24","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"24-29","source":"Crossref","is-referenced-by-count":27,"title":["Generalized herpes simplex in malnourished children"],"prefix":"10.1136","volume":"23","author":[{"given":"A. C.","family":"Templeton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1970,2,1]]},"reference":[{"key":"ref_1","first-page":"109","article-title":"The epidemiology of herpes virus infection in three racial communities in Cape Town","volume":"40","author":"Becker, W.B.","year":"1966","unstructured":"Becker, W. B. (1966). The epidemiology of herpes virus infection in three racial communities in Cape Town. S. Afr. med. J., 40, 109-111.","journal-title":"S. Afr. med. J"},{"key":"ref_2","first-page":"74","article-title":"Virus studies in disseminated herpes simplex infections","volume":"37","author":"Becker, W.B.; Naud6, L.du T.; Kipps, A.; MacKenzie, D.","year":"1963","unstructured":"Becker, W. B., Naud6, L. du T., Kipps, A., and MacKenzie, D. (1963). Virus studies in disseminated herpes simplex infections. S. Afr. med. J., 37, 74-76.","journal-title":"S. Afr. med. J"},{"key":"ref_3","first-page":"52","article-title":"The epidemiology of herpes simplex in the Pretoria Bantu population. S","volume":"1","author":"Coetzee, J.N.","year":"1955","unstructured":"Coetzee, J. N. (1955). The epidemiology of herpes simplex in the Pretoria Bantu population. S. Afr. J. Lab. clin. Med., 1, 52-56.","journal-title":"Afr. J. Lab. clin. 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Immunol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/jcp.3.3.239","article-title":"A complement fixation test for herpes simplex infections","volume":"3","author":"Dudgeon, J.A.","year":"1950","unstructured":"Dudgeon, J. A. (1950). A complement fixation test for herpes simplex infections. J. clin. Path., 3, 239-247.","journal-title":"J. clin. Path"},{"key":"ref_7","first-page":"233","article-title":"Tuberculin sensitivity following B. C. G. vaccination in undernourished children","volume":"42","author":"Harland, P.S.E.G.; Brown, R.E.","year":"1965","unstructured":"Harland, P. S. E. G., and Brown, R. E. (1965). Tuberculin sensitivity following B.C.G. vaccination in undernourished children. E. Afr. med. J., 42, 233-238.","journal-title":"E. Afr. med. J"},{"key":"ref_8","first-page":"127","article-title":"Hepato-adrenal necrosis with intranuclear inclusion bodies","volume":"11","author":"Hass, G.M.","year":"1935","unstructured":"Hass, G. M. (1935). Hepato-adrenal necrosis with intranuclear inclusion bodies. Amer. J. Path., 11, 127-142.","journal-title":"Amer. J. Path"},{"key":"ref_9","first-page":"346","article-title":"Pathology and Treatment of Disease of the Skin","author":"Kaposi, M.","year":"1895","unstructured":"Kaposi, M. (1895). Pathology and Treatment of Disease of the Skin, p. 346. Wood, New York."},{"key":"ref_10","first-page":"647","article-title":"Fatal disseminated primary herpes virus infection in children: epidemiology based on 93 non-neonatal cases","volume":"41","author":"Kipps, A.Becker; W., Wainwright; J.; MacKenzie, D.","year":"1967","unstructured":"Kipps, A. Becker, W., Wainwright, J., and MacKenzie, D. (1967). Fatal disseminated primary herpes virus infection in children: epidemiology based on 93 non-neonatal cases. S. Afr. med. J., 41, 647-651.","journal-title":"S. Afr. med. J"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/bmj.3.5617.529","article-title":"Tuberculin test in malnourished children","volume":"3","author":"Lloyd, A.P.C.","year":"1968","unstructured":"Lloyd, A. P. C. (1968). Tuberculin test in malnourished children. Brit. med. J., 3, 529-531.","journal-title":"Brit. med. J"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1083\/jcb.17.2.237","article-title":"Cytochemical studies of the nucleo-proteins of HeLa cells infected with herpes virus","volume":"17","author":"Love, R.; Wildy, P.","year":"1963","unstructured":"Love, R., and Wildy, P. (1963). Cytochemical studies of the nucleo-proteins of HeLa cells infected with herpes virus. J. cell. Biol., 17, 237-254.","journal-title":"J. cell. Biol"},{"key":"ref_13","first-page":"434","article-title":"Recovery of herpes simplex virus from the blood of a patient with herpetic rhinitis","volume":"35","author":"Ruchman, I.; Dodd, K.","year":"1950","unstructured":"Ruchman, I., and Dodd, K. (1950). Recovery of herpes simplex virus from the blood of a patient with herpetic rhinitis. J. Lab. clin. Med., 35, 434-439.","journal-title":"J. Lab. clin. Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0002-9394(57)91496-4","article-title":"Epidemiology of herpetic infections","volume":"43","author":"Scott, T.F.McN","year":"1957","unstructured":"Scott, T. F. McN. (1957). Epidemiology of herpetic infections. Amer. J. Ophthal., 43, April, Part 2, 134-147.","journal-title":"Amer. J. Ophthal"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/infdis\/116.4.455","article-title":"Interferon and antibody production in mice with herpes simplex skin infections","volume":"116","author":"Sydiskis, R.J.; Schultz, I.","year":"1966","unstructured":"Sydiskis, R. J., and Schultz, I. (1966). Interferon and antibody production in mice with herpes simplex skin infections. J. infect. Dis., 116, 455-460.","journal-title":"J. infect. Dis"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-2964(65)90006-X","article-title":"The isolation in mice of strains of herpes virus from Burkitt tumours","volume":"1","author":"Woodall, J.P.; Williams, M.C.; Simpson, D.I.H.; Haddow, A.J.","year":"1965","unstructured":"Woodall, J. P., Williams, M. C., Simpson, D. I. H., and Haddow, A. J. (1965).The isolation in mice of strains of herpes virus from Burkitt tumours. Europ. J. Cancer, 1, 137-140.","journal-title":"Europ. J. Cancer"},{"key":"ref_17","first-page":"16","article-title":"Nutrition and infection","volume":"314","author":"World Health Organisation Expert Committee","year":"1965","unstructured":"World Health Organisation Expert Committee (1965). Nutrition and infection. Wld. Hlth. Org. Techn. Rep. Ser., 314, 16.","journal-title":"Wld. Hlth. Org. Techn. Rep. Ser"},{"key":"ref_18","first-page":"421","article-title":"Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy","volume":"83","author":"Zuelzer, W.W.; Stuhlberg, C.S.","year":"1952","unstructured":"Zuelzer, W. W., and Stuhlberg, C. S. (1952). Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy. Amer. J. dis. Child., 83, 421-439.","journal-title":"Amer. J. dis. Child"},{"key":"ref_19","article-title":"showed that indirect immunofluorescence will detect the antigen of herpes simplex virus in formalin-fixed tissue, this technique was applied to material from the cases described above, in the hope of getting Case 4 Many patches of liver cells showed specific staining, and in adrenal there were areas of necrosis with specifically stained cells at their edges in the cortex","author":"Sabin, As; Messore","year":"1961","unstructured":"As Sabin and Messore (1961) showed that indirect immunofluorescence will detect the antigen of herpes simplex virus in formalin-fixed tissue, this technique was applied to material from the cases described above, in the hope of getting Case 4 Many patches of liver cells showed specific staining, and in adrenal there were areas of necrosis with specifically stained cells at their edges in the cortex."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.23.1.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:30:05Z","timestamp":1765600205000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.23.1.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,2]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1970,2,1]]},"published-print":{"date-parts":[[1970,2]]}},"alternative-id":["10.1136\/jcp.23.1.24"],"URL":"https:\/\/doi.org\/10.1136\/jcp.23.1.24","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,2]]}}}