{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:46:38Z","timestamp":1790419598976,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1970,7]]},"abstract":"<jats:p>Studies were carried out on eight patients with primary biliary cirrhosis. Four patients were found to have a haemolytic anaemia; one had Coombs red cell antibodies. Two patients had evidence of splenic sequestration of red cells using the radio-chromium technique. There was a significant correlation between the red cell survival and the bromsulphthalein retention test and the red cell survival and the serum level of bilirubin. It was concluded that the anaemia of cirrhosis of the liver, including primary biliary cirrhosis, may be due to a number of mechanisms and a unifying hypothesis based on the degree of liver dysfunction is suggested.<\/jats:p>","DOI":"10.1136\/jcp.23.5.397","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"397-401","source":"Crossref","is-referenced-by-count":12,"title":["Red cell survival in biliary cirrhosis"],"prefix":"10.1136","volume":"23","author":[{"given":"R.","family":"Hume","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Whitelaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1970,7,1]]},"reference":[{"key":"ref_1","first-page":"351","article-title":"Red cell life-span in nephritis and hepatic cirrhosis","volume":"12","author":"Chaplin, Jr., H.; Mollison, P.L.","year":"1953","unstructured":"Chaplin, H., Jr., and Mollison, P. L. (1953). Red cell life-span in nephritis and hepatic cirrhosis. Clin. Sci., 12, 351-360.","journal-title":"Clin. Sci"},{"key":"ref_2","first-page":"885","article-title":"L'equilibre erythrocyaire des cirrhoses du foie","volume":"31","author":"Combrisson, A.","year":"1960","unstructured":"Combrisson, A. (1960). L'equilibre erythrocyaire des cirrhoses du foie. Sang, 31, 885-904.","journal-title":"Sang"},{"key":"ref_3","article-title":"Practical Haematology","author":"Dacie, J.V.; Lewis, S.M.","year":"1963","unstructured":"Dacie, J. V., and Lewis, S. M. (1963). Practical Haematology, 3rd ed. Churchill, London.","edition":"3rd ed"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0016-5085(63)80003-7","article-title":"Pathogenesis of indirect reacting hyperbilirubinemia after portacaval anastomosis","volume":"44","author":"da Silva, L.C.; Jamra, M.A.; Maspes, V.; Pontes, J.F.; Pieroni, R.R.; Cintra, A.B.DeU","year":"1963","unstructured":"da Silva, L. C., Jamra, M. A., Maspes, V., Pontes, J. F., Pieroni, R. R., and Cintra, A. B. DeU. (1963). Pathogenesis of indirect reacting hyperbilirubinemia after portacaval anastomosis. Gastroenterology, 44, 117-124.","journal-title":"Gastroenterology"},{"key":"ref_5","first-page":"1801","article-title":"L'hemolyse dans les cirrhoses. Etude de 40 cas par la methode des hematies marqu6es du chrome 51. Sem. H6p","volume":"34","author":"Fauvert, R.; Loverdo, A.; Nicollo, S.; Boivin, P.","year":"1958","unstructured":"Fauvert, R., Loverdo, A., Nicollo, S., and Boivin, P. (1958). L'hemolyse dans les cirrhoses. Etude de 40 cas par la methode des hematies marqu6es du chrome 51. Sem. H6p. Paris, 34, 1801.","journal-title":"Paris"},{"key":"ref_6","article-title":"Autoimmunity and Disease","author":"Glynn, L.E.; Holborow, E.J.","year":"1965","unstructured":"Glynn, L. E., and Holborow, E. J. (1965). Autoimmunity and Disease. Blackwell, Oxford."},{"key":"ref_7","first-page":"109","article-title":"Radiochromium in the selection of patients with haemolytic anaemia for splenectomy","volume":"1","author":"Goldberg, A.; Hutchison, H.E.; MacDonald, E.","year":"1966","unstructured":"Goldberg, A., Hutchison, H. E., and MacDonald, E. (1966). Radiochromium in the selection of patients with haemolytic anaemia for splenectomy. Lancet, 1, 109-114.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/jcp.19.6.527","article-title":"Serological and histological diagnosis of primary biliary cirrhosis","volume":"19","author":"Goudie, R.B.; MacSween, R.N.M.; Goldberg, D.M.","year":"1966","unstructured":"Goudie, R. B., MacSween, R. N. M., and Goldberg, D. M. (1966). Serological and histological diagnosis of primary biliary cirrhosis. J. clin. Path., 19, 527-538.","journal-title":"J. clin. Path"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0002-9343(60)90148-0","article-title":"Erythrocyte dynamics in liver disease","volume":"28","author":"Hall, C.A.","year":"1960","unstructured":"Hall, C. A. (1960). Erythrocyte dynamics in liver disease. Amer. J. Med., 28, 541-549.","journal-title":"Amer. J. Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI104997","article-title":"Influence of the spleen size and portal pressure on erythrocyte sequestration","volume":"43","author":"Haozbach, R.T.; Shipley, R.A.; Clark, R.E.; Chudzik, E.B.","year":"1964","unstructured":"Haozbach, R. T., Shipley, R. A., Clark, R. E., and Chudzik, E. B. (1964). Influence of the spleen size and portal pressure on erythrocyte sequestration. J. clin. Invest., 43, 1125-1135.","journal-title":"J. clin. Invest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/ard.23.4.267","article-title":"Anaemia of Felty's syndrome","volume":"23","author":"Hume, R.; Dagg, J.H.; Fraser, T.N.; Goldberg, A.","year":"1964","unstructured":"Hume, R., Dagg, J. H., Fraser, T. N., and Goldberg, A. (1964). Anaemia of Felty's syndrome. Ann. rheum. Dis., 23, 267-271.","journal-title":"Ann. rheum. Dis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/00000441-195104000-00014","article-title":"Hemolytic anaemia associated with liver disease","volume":"221","author":"Hyman, G.A.; Southworth, H.","year":"1951","unstructured":"Hyman, G. A., and Southworth, H. (1951). Hemolytic anaemia associated with liver disease. Amer. J. med. Sci., 221, 448-456.","journal-title":"Amer. J. med. Sci"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1172\/JCI103087","article-title":"The anemia of liver disease: observations on its mechanism","volume":"34","author":"Jandl, J.H.","year":"1955","unstructured":"Jandl, J. H. (1955). The anemia of liver disease: observations on its mechanism. J. clin. Invest., 34, 390-404.","journal-title":"J. clin. Invest"},{"key":"ref_14","first-page":"35","article-title":"Clinical determination of the sites of red cell sequestration in hemolytic anemias","author":"JandI, J.H.; Greenberg, M.S.; Yonemoto, R.H.; Castle, W.B.","year":"1956","unstructured":"JandI, J. H., Greenberg, M. S., Yonemoto, R. H., and Castle, W. B. (1956). Clinical determination of the sites of red cell sequestration in hemolytic anemias. J. clin. Invest., 35,842-867.","journal-title":"J. clin. Invest"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archinte.1955.00250070109013","article-title":"Decreased red cell survival associated with liver disease","volume":"95","author":"Jones, P.N.; Weinstein, I.M.; Ettinger, R.H.; Capps, R.B.","year":"1955","unstructured":"Jones, P. N., Weinstein, I. M., Ettinger, R. H., and Capps, R. B. (1955). Decreased red cell survival associated with liver disease. Arch. intern. Med., 95, 93-102.","journal-title":"Arch. intern. Med"},{"key":"ref_16","author":"Katz, R.; Velasco, M.; Guzman, C.; Alessandri, H.","year":"1964","unstructured":"Katz, R., Velasco, M., Guzman, C., and Alessandri, H. (1964)."},{"key":"ref_17","first-page":"33","article-title":"The mechanism of anaemia in chronic liver disease","volume":"34","author":"Kimber, C.; Deller, D.J.; Ibbotson, R.N.; Lander, H.","year":"1965","unstructured":"Kimber, C., Deller, D. J., Ibbotson, R. N., and Lander, H. (1965). The mechanism of anaemia in chronic liver disease. Quart. J. Med., 34, 33-64.","journal-title":"Quart. J. Med"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2141.1955.tb05489.x","article-title":"Use of the isotope \"'Cr as label for red cells","volume":"1","author":"Mollison, P.L.; Veall, H.","year":"1955","unstructured":"Mollison, P. L., and Veall, H. (1955). Use of the isotope \"'Cr as label for red cells. Brit. J. Haemat., 1, 62-74.","journal-title":"Brit. J. Haemat"},{"key":"ref_19","first-page":"24","article-title":"Reduced red cell survival in jaundice and its relation to abnormal glutathione metabolism","author":"Pitcher, C.S.; Williams, R.","year":"1963","unstructured":"Pitcher, C. S., and Williams, R. (1963). Reduced red cell survival in jaundice and its relation to abnormal glutathione metabolism. Clin. Sci., 24,239-252.","journal-title":"Clin. Sci"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1365-2141.1968.tb01562.x","article-title":"Red cell survival in experimental cholestatic jaundice","volume":"15","author":"Powell, L.W.; Dunnicliff, M.A.; Billing, B.H.","year":"1968","unstructured":"Powell, L. W., Dunnicliff, M. A., and Billing, B. H. (1968). Red cell survival in experimental cholestatic jaundice. Brit. J. Haemat., 15, 429-435.","journal-title":"Brit. J. Haemat"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1056\/NEJM196408202710804","article-title":"Spur-cell anemia. Hemolytic anemia with red cells resembling acanthocytes in alcoholic cirrhosis","volume":"271","author":"Smith, J.A.; Lonergan, E.T.; Sterling, K.","year":"1964","unstructured":"Smith, J. A., Lonergan, E. T., and Sterling, K. (1964). Spur-cell anemia. Hemolytic anemia with red cells resembling acanthocytes in alcoholic cirrhosis. New Engl. J. Med., 271, 396-398.","journal-title":"New Engl. J. Med"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1365-2141.1967.tb08844.x","article-title":"Red cell survival and splenic accumulation of radiochromium in liver cirrhosis with splenomegaly","volume":"13","author":"Subhiyah, B.W.; Al-Hindawi, A.Y.","year":"1967","unstructured":"Subhiyah, B. W., and Al-Hindawi, A. Y. (1967). Red cell survival and splenic accumulation of radiochromium in liver cirrhosis with splenomegaly. Brit. J. Haemat., 13, 773-778.","journal-title":"Brit. J. Haemat"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJM195004202421601","article-title":"Splenectomy in blood dyscrasias","volume":"242","author":"Welch, C.S.; Dameshek, W.","year":"1950","unstructured":"Welch, C. S., and Dameshek, W. (1950). Splenectomy in blood dyscrasias. New Engl. J. Med., 242, 601-606.","journal-title":"New Engl. J. Med"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0140-6736(61)92481-3","article-title":"Action of steroid therapy in jaundice","volume":"2","author":"Williams, R.; Billing, B.H.","year":"1961","unstructured":"Williams, R., and Billing, B. H. (1961). Action of steroid therapy in jaundice. Lancet, 2, 392-396.","journal-title":"Lancet"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.23.5.397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:53:04Z","timestamp":1765702384000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.23.5.397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,7]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1970,7,1]]},"published-print":{"date-parts":[[1970,7]]}},"alternative-id":["10.1136\/jcp.23.5.397"],"URL":"https:\/\/doi.org\/10.1136\/jcp.23.5.397","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,7]]}}}