{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:39:40Z","timestamp":1765006780975,"version":"3.46.0"},"reference-count":32,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1970,7]]},"abstract":"<jats:p>A composite malignant tumour arising in the breast of an elderly woman is described. The cystic tumour containing areas of squamous metaplasia, bone formation, adenocarcinoma, and osteosarcoma was surrounded by the typical changes of mammary dysplasia (fibroadenosis).<\/jats:p>\n                  <jats:p>The classification and acceptance of such tumours is highly debatable. There is no one acceptable classification of breast sarcomas and hence the prognosis of such neoplasms, particularly those containing heterologous tissues, is poorly defined. Evidence is presented in support of such composite tumours as being definite entities which arise from the closely associated epithelial and mesenchymal components of the breast simultaneously.<\/jats:p>","DOI":"10.1136\/jcp.23.5.414","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"414-422","source":"Crossref","is-referenced-by-count":7,"title":["A composite malignant tumour of the elderly female breast"],"prefix":"10.1136","volume":"23","author":[{"given":"D. M.","family":"Wayte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. G.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1970,7,1]]},"reference":[{"key":"ref_1","first-page":"589","article-title":"So-called mixed tumours of the mammary gland of dog and man with special reference to the general problem of cartilage and bone formation","volume":"29","author":"Allen, A.C.","year":"1940","unstructured":"Allen, A. C. (1940). So-called mixed tumours of the mammary gland of dog and man with special reference to the general problem of cartilage and bone formation. Arch. Path., 29, 589-624.","journal-title":"Arch. Path"},{"key":"ref_2","first-page":"313","article-title":"Salivary gland tumours and their mucins","volume":"77","author":"Azzopardi, J. G.; Smith, 0. D","year":"1959","unstructured":"Azzopardi, J. G., and Smith, 0. D. (1959). Salivary gland tumours and their mucins. J. Path. Bact., 77, 313-140.","journal-title":"J. Path. Bact"},{"key":"ref_3","first-page":"107","article-title":"Sarcoma of the mammary gland","year":"1958","unstructured":"Botham, R. J., McDonald, J. R., and Clagett, 0. T. (1958). Sarcoma of the mammary gland. Surg. Gynec. Obstet., 107,55-61.","journal-title":"Surg. Gynec. Obstet"},{"key":"ref_4","first-page":"300","volume-title":"Pathological ossification and osseous metaplasia in man. In Modern Trends in Pathology, 1st series","author":"Coilins, D.H.; Curran, R.C.","year":"1959","unstructured":"Coilins, D. H., and Curran, R. C. (1959). Pathological ossification and osseous metaplasia in man. In Modern Trends in Pathology, 1st series, edited by-D. H. Collins, pp. 300-334. Butterworth, London."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/path.1700680210","article-title":"Localised myositis ossificans","volume":"68","author":"Constance, T.J.","year":"1954","unstructured":"Constance, T. J. (1954). Localised myositis ossificans. J. Path. Bact., 68, 381-385.","journal-title":"J. Path. Bact"},{"key":"ref_6","first-page":"15","article-title":"Sarcoma of breast with particular reference to its origin from flbroadenoma","author":"Curran, R. C.; Dodge, 0. G","year":"1962","unstructured":"Curran, R. C., and Dodge, 0. G. (1962). Sarcoma of breast with particular reference to its origin from flbroadenoma. J. clin. Path., 15,1-16.","journal-title":"J. clin. Path"},{"key":"ref_7","first-page":"17","article-title":"Cystic disease of the breast: relationship to carcinoma","author":"Davis, H.H.; Simons, M.; Davis, J.B.","year":"1964","unstructured":"Davis, H. H., Simons, M., and Davis, J. B. (1964). Cystic disease of the breast: relationship to carcinoma. Cancer (Philad.), 17,957-978."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/bjc.1967.31","article-title":"Sarcoma of breast","volume":"21","author":"Fawcett, F.J.","year":"1967","unstructured":"Fawcett, F. J. (1967). Sarcoma of breast. Brit. J. Cancer, 21, 285-294.","journal-title":"Brit. J. Cancer"},{"key":"ref_9","first-page":"151","article-title":"A necropsy study of canine malignant mammary neoplasms","author":"Fidler, I.J.; Broley, R.S.","year":"1967","unstructured":"Fidler, I. J., and Broley, R. S. (1967). A necropsy study of canine malignant mammary neoplasms. J. Amer. vet. med. Ass., 151,710-715.","journal-title":"J. Amer. vet. med. Ass"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/1097-0142(196708)20:8<1234::AID-CNCR2820200808>3.0.CO;2-L","article-title":"Malignant tumor of the breast with bone formation Studies by light and electron microscopy","volume":"20","author":"Gonzalez-Licea, A.; Yardley, J.H.; Hartmann, W.H.","year":"1967","unstructured":"Gonzalez-Licea, A., Yardley, J. H., and Hartmann, W. H. (1967). Malignant tumor of the breast with bone formation Studies by light and electron microscopy. Cancer (Philad.), 20, 1234-1247.","journal-title":"Cancer (Philad.)"},{"key":"ref_11","author":"Hill, R.P.; Stout, A.P.","year":"1942","unstructured":"Hill, R. P., and Stout, A. P. (1942). Sarcoma of the breast. Arch. Surg.,44,723-759.","journal-title":"Sarcoma of the breast. Arch. Surg.,44,723-759"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1001\/archsurg.1931.01160030026002","article-title":"The formation of bone under the influence of epithelium of the urinary tract","volume":"22","author":"Huggins, C.B.","year":"1931","unstructured":"Huggins, C. B. (1931). The formation of bone under the influence of epithelium of the urinary tract. Arch. Surg., 22, 377-408.","journal-title":"Arch. Surg"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/ajcp\/40.5.521","article-title":"Osteogenic sarcoma of the mammary gland","volume":"40","year":"1963","unstructured":"Jernstrom, P., Lindberg, A. L., and Meland, 0. N. (1963). Osteogenic sarcoma of the mammary gland. Amer. J. clin. Path., 40, 521-526.","journal-title":"Amer. J. clin. Path"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/bjc.1967.74","article-title":"Sarcoma of the breast","volume":"21","author":"Kennedy, T.; Biggart, J.D.","year":"1967","unstructured":"Kennedy, T., and Biggart, J. D. (1967). Sarcoma of the breast. Brit. J. Cancer., 21, 635-644.","journal-title":"Brit. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1001\/jama.1967.03130070051015","article-title":"Sarcomas of the breast","author":"Lattes, R.","year":"1967","unstructured":"Lattes, R. (1967). Sarcomas of the breast. J. Amer. med. Ass., 201, 531-532.","journal-title":"J. Amer. med. Ass"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/1097-0142(196807)22:1<22::AID-CNCR2820220105>3.0.CO;2-R","article-title":"Sarcomas and related mesenchymal tumors of the breast","volume":"22","author":"Norris, H.J.; Taylor, H.B.","year":"1968","unstructured":"Norris, H. J., and Taylor, H. B. (1968). Sarcomas and related mesenchymal tumors of the breast. Cancer (Philad.), 22, 22-28.","journal-title":"Cancer (Philad.)"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/1097-0142(196506)18:6<697::AID-CNCR2820180607>3.0.CO;2-L","article-title":"Cystosarcoma phyllodes. A clinicopathologic study of hypercellular periductal stromal neoplasms of breast","volume":"18","author":"Oberman, H.A.","year":"1965","unstructured":"Oberman, H. A. (1965a). Cystosarcoma phyllodes. A clinicopathologic study of hypercellular periductal stromal neoplasms of breast. Cancer (Philad.), 18, 697-710.","journal-title":"Cancer (Philad.)"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/1097-0142(196510)18:10<1233::AID-CNCR2820181004>3.0.CO;2-M","article-title":"Sarcomas of the breast","volume":"18","author":"Oberman, H.A.","year":"1965","unstructured":"Oberman, H. A. (1965b). Sarcomas of the breast. Cancer (Philad.), 18, 1233-1243.","journal-title":"Cancer (Philad.)"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/path.1700760205","article-title":"Bony and cartilagenous tumours of the urinary bladder","volume":"76","author":"Pang, L.S.C.","year":"1958","unstructured":"Pang, L. S. C. (1958). Bony and cartilagenous tumours of the urinary bladder. J. Pcth. Bact., 76, 357-377.","journal-title":"J. Pcth. Bact"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/path.1700750207","article-title":"Two rare breast tumours","volume":"75","author":"Robb, P.M.; Macfarlane, A.","year":"1958","unstructured":"Robb, P. M., and Macfarlane, A. (1958). Two rare breast tumours. J. Path. Bact., 75, 293-298.","journal-title":"J. Path. Bact"},{"key":"ref_21","first-page":"44","article-title":"Osteoid sarcoma of the breast: a complication of fibroadenoma","volume":"40","author":"Rottino, A.; Howley, C.P.","year":"1945","unstructured":"Rottino, A., and Howley, C. P. (1945). Osteoid sarcoma of the breast: a complication of fibroadenoma. Arch. Path., 40, 44-50.","journal-title":"Arch. Path"},{"key":"ref_22","first-page":"74","article-title":"Epidermoid metaplasia in mammary fibroadenoma with formation of keratin cysts","author":"Salm, R.","year":"1957","unstructured":"Salm, R. (1957). Epidermoid metaplasia in mammary fibroadenoma with formation of keratin cysts. J. Path. Bact., 74,221-222.","journal-title":"J. Path. Bact"},{"key":"ref_23","first-page":"1325","article-title":"A survey of feline neoplasms","volume":"151","author":"Schlnidt, R.E.; Langham, R.F.","year":"1967","unstructured":"Schlnidt, R. E., and Langham, R. F. (1967). A survey of feline neoplasms. J. Amer. vet. med. Ass., 151, 1325-1328.","journal-title":"J. Amer. vet. med. Ass"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0030-4220(67)90485-9","article-title":"Osteosarcoma of breast metastasing to the oral cavity","volume":"23","author":"Shapiro, R.; Reichman, L.; Getzoff, C.; Weiss, A.","year":"1967","unstructured":"Shapiro, R., Reichman, L., Getzoff, C., and Weiss, A. (1967). Osteosarcoma of breast metastasing to the oral cavity. Oral Surg., 23, 58-61.","journal-title":"Oral Surg"},{"key":"ref_25","first-page":"51","article-title":"The occurrence of bone and cartilage in mammary tumors","author":"Smith, B.H.; Taylor, H.B.","year":"1969","unstructured":"Smith, B. H., and Taylor, H. B. (1969). The occurrence of bone and cartilage in mammary tumors. Amer. J. clin. Path., 51,610-618.","journal-title":"Amer. J. clin. Path"},{"key":"ref_26","first-page":"66","article-title":"Tumors of the breast. Atlas of Tumor Pathology, Sect","volume":"34","author":"Stewart, F.W.","year":"1950","unstructured":"Stewart, F. W. (1950). Tumors of the breast. Atlas of Tumor Pathology, Sect. IX, Fasc. 34, p. 66. Armed Forces Institute of Pathology, Washington.","journal-title":"IX, Fasc"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/path.1700480304","article-title":"A complex malignant mammary tumour","volume":"48","author":"Tudhope, G.R.","year":"1939","unstructured":"Tudhope, G. R. (1939). A complex malignant mammary tumour J. Path. Bact., 48, 499-506.","journal-title":"J. Path. Bact"},{"key":"ref_28","first-page":"76","article-title":"Squamous-cell mammary carcinoma of predominantly fibrosarcoma-like structure","author":"Willis, R.A.","year":"1958","unstructured":"Willis, R. A. (1958). Squamous-cell mammary carcinoma of predominantly fibrosarcoma-like structure. J. Path. Bact., 76,511-515.","journal-title":"J. Path. Bact"},{"key":"ref_29","first-page":"108","article-title":"Mammary tumours","volume-title":"Modern Trends in Pathology, 1st series","author":"Willis, R.A.","year":"1959","unstructured":"Willis, R. A. (1959). Mammary tumours. In Modern Trends in Pathology, 1st series, edited by D. H. Collins, p. 108. Butterworth, London."},{"key":"ref_30","first-page":"523","article-title":"The Borderland ofEmbryology and Pathology","author":"Willis, R.A.","year":"1962","unstructured":"Willis, R. A. (1962). The Borderland ofEmbryology and Pathology, 2nd ed., p. 523. Butterworth, London.","edition":"2nd ed"},{"key":"ref_31","first-page":"pp.","article-title":"Pathology of Tumours","author":"Willis, R.A.","year":"1967","unstructured":"Willis, R. A. (1967). Pathology of Tumours. 4th ed., pp. 212, 219, and 703-704. Butterworth, London.","edition":"4th ed"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/path.1700640419","article-title":"A mixed tumour of salivary gland showing bone formation, with a histochemical study of the tumour mucoids","volume":"64","author":"Yates, P.O.; Paget, G.E.","year":"1952","unstructured":"Yates, P. O., and Paget, G. E. (1952). A mixed tumour of salivary gland showing bone formation, with a histochemical study of the tumour mucoids. J. Path. Bact., 64, 881-888.","journal-title":"J. Path. Bact"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.23.5.414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:38:03Z","timestamp":1765006683000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.23.5.414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,7]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1970,7,1]]},"published-print":{"date-parts":[[1970,7]]}},"alternative-id":["10.1136\/jcp.23.5.414"],"URL":"https:\/\/doi.org\/10.1136\/jcp.23.5.414","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1970,7]]}}}