{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:08:05Z","timestamp":1764997685825,"version":"3.46.0"},"reference-count":21,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1970,10]]},"abstract":"<jats:p>Structural chromosomal aberrations, in the form of breaks, were found in a significantly higher proportion of bone marrow cells in patients with infective hepatitis than in controls. These anomalies were observed during the first and third weeks after the onset of jaundice but had subsided by the sixth week.<\/jats:p>\n                  <jats:p>Chromosomal aberrations did not appear to be related to the severity of infective hepatitis or to the sex or age of the patients.<\/jats:p>\n                  <jats:p>\n                    The distribution of chromosomal abnormalities did not appear to be random; they were observed predominantly in the A\n                    <jats:sub>2<\/jats:sub>\n                    and B\n                    <jats:sub>4-5<\/jats:sub>\n                    series. Since no abnormalities were detected in the G-group chromosomes, no evidence in support of a relationship between infective hepatitis and Down's syndrome was obtained.\n                  <\/jats:p>\n                  <jats:p>Numerical chromosomal aberrations were not observed, nor was any evidence obtained that mitotic activity of bone marrow cells is suppressed in patients with infective hepatitis.<\/jats:p>","DOI":"10.1136\/jcp.23.7.553","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"553-557","source":"Crossref","is-referenced-by-count":9,"title":["Chromosomal aberrations in infective hepatitis"],"prefix":"10.1136","volume":"23","author":[{"given":"N.","family":"Matsaniotis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kiossoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Maounis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Anagnostakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1970,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1601-5223.1963.tb01891.x","article-title":"Chromosome breaks in leukocytes of chickenpox patients. 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Sci. fenn; A proposed standard system of nomenclature of human mitotic chromosomes"},{"key":"ref_3","first-page":"285","article-title":"Chromosomal breaks in human leukocyte cultures induced by an agent in the plasma of infectious hepatitis patients","volume":"52","year":"1965","unstructured":"El-Alfi, 0. S., Smith, P. M., and Biesele, J. J. (1965). Chromosomal breaks in human leukocyte cultures induced by an agent in the plasma of infectious hepatitis patients. Hereditas, 52, 285-294.","journal-title":"Hereditas"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/192145a0","article-title":"Chromosomal aberrations induced by an animal virus","volume":"192","author":"Hampar, B.; Ellison, S.A.","year":"1961","unstructured":"Hampar, B., and Ellison, S. A. (1961). Chromosomal aberrations induced by an animal virus. 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G., Dagna-Bricarelli, F., and Tortorolo, G. (1965). Chickenpox and chromosome aberrations. Brit. med. J., 2, 172.","journal-title":"Brit. med. J"},{"key":"ref_10","first-page":"1421","article-title":"Chromosomes in infectious hepatitis","volume":"2","author":"Matsaniotis, N.; Kiossoglou, K.A.; Maounis, F.; Anagnostakis, D.E.","year":"1966","unstructured":"Matsaniotis, N., Kiossoglou, K. A., Maounis, F., and Anagnostakis, D. E. (1966). Chromosomes in infectious hepatitis. Lancet, 2, 1421.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.155.3758.80","article-title":"Leukocyte mitosis: suppression in vitro associated with acute infectious hepatitis","volume":"155","author":"Mella, B.; Lang, D.J.","year":"1967","unstructured":"Mella, B., and Lang, D. J. (1967). Leukocyte mitosis: suppression in vitro associated with acute infectious hepatitis. Science, 155, 80-81.","journal-title":"Science"},{"key":"ref_12","series-title":"Hereditas; Relationships-of viruses, chromosomes and careinogenesis","first-page":"53","article-title":"Non-random chromosomal aberrations in SV 40-transformed human cells. J. cell comp","volume":"50","author":"Moorhead, P.S.; Saksela, E.","year":"1963","unstructured":"Moorhead, P. S., and Saksela, E. (1963). Non-random chromosomal aberrations in SV 40-transformed human cells. J. cell comp. Phy)rAa 57-3-.. Nichols,'W. W. (1963). 'Relationships-of viruses, chromosomes and careinogenesis. Hereditas, 50, 53-80."},{"key":"ref_13","first-page":"367","article-title":"Measles-associated chromosome breakage, Preliminary communication","volume":"48","author":"Nichols, W.W.; Levan, A.; Hall, B.; tSstergren, G.","year":"1962","unstructured":"Nichols, W. W., Levan, A., Hall, B., and tSstergren, G. (1962). Measles-associated chromosome breakage, Preliminary communication. 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