{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:44:59Z","timestamp":1758807899223,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1970,10]]},"abstract":"<jats:p>Results of the <jats:sup>57<\/jats:sup>Co vitamin B<jats:sub>12<\/jats:sub> plasma level absorption test are described in 163 patients. The use of intramuscular carbachol with the test and the presence or absence of current vitamin B<jats:sub>12<\/jats:sub> therapy did not affect the test results. Injection of 1,000 \u03bcg of unlabelled vitamin B<jats:sub>12<\/jats:sub> during the test augmented plasma levels in patients with normal absorption but tests without this injection gave satisfactory differentiation between the normal and malabsorption ranges. Results from patients having had a gastrectomy, ileal resection, or a past history of adult coeliac disease are also described. Amongst patients with presumed Addisonian pernicious anaemia, two with unresolved equivocal results and three with falsely normal results were found. The significance of these is discussed.<\/jats:p>","DOI":"10.1136\/jcp.23.7.569","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"569-571","source":"Crossref","is-referenced-by-count":12,"title":["Studies on the <sup>57<\/sup>Co vitamin B<sub>12<\/sub> plasma level absorption test"],"prefix":"10.1136","volume":"23","author":[{"given":"B. K.","family":"Armstrong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Woodliff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1970,10,1]]},"reference":[{"issue":"3","key":"ref_1","first-page":"4","article-title":"The occurrence of normal plasma levels of 5'Co vitamin B12 in patients with strong suspicion of, or demonstrated by the Schilling test, vitamin B12 malabsorption, has been reported by other workers (McCurdy, 1965; McIntyre and Wagner, 1966)","volume":"88","year":"1966","unstructured":"The occurrence of normal plasma levels of 5'Co vitamin B12 in patients with strong suspicion of, or demonstrated by the Schilling test, vitamin B12 malabsorption, has been reported by other workers (McCurdy, 1965; McIntyre and Wagner, 1966). McIntyre and Wagner (1966) found a 31 % incidence of false normals if the lower limit of normal was set at 0 25 % of the dose per litre and 7 % if the lower limit of normal was set at 0-65 % of the dose per litre. On our criteria, three out of 88 (3 4%) patients in our series with vitamin B12 malabsorption gave falsely normal results. Thus","journal-title":"of; found a 31 % incidence of false normals if the lower limit of normal was set at 0 25 % of the dose per litre and 7 % if the lower limit of normal was set at 0-65 % of the dose per litre. On our criteria, three out"},{"key":"ref_2","article-title":"Vitamin B,, absorption studies: comparison of 'uCo vitamin B,2","author":"Armstrong, B.K.; Woodliff, H.J.","year":"1966","unstructured":"Armstrong, B. K., and Woodliff, H. J. (1966). Vitamin B,, absorption studies: comparison of 'uCo vitamin B,2"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.5694\/j.1326-5377.1967.tb21648.x","article-title":"Vitamin B1, absorption studies-the effect of carbachol and gastrin on the \"Co-labelled vitamin B1, plasma level absorption test in patients with pernicious anaemia","volume":"1","author":"Armstrong, B.K.; Woodliff, H.J.","year":"1967","unstructured":"Armstrong, B. K., and Woodliff, H. J. (1967). Vitamin B1, absorption studies-the effect of carbachol and gastrin on the \"Co-labelled vitamin B1, plasma level absorption test in patients with pernicious anaemia. Med. J. Aust., 1, 819-820.","journal-title":"Med. J. Aust"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.5694\/j.1326-5377.1969.tb107347.x","article-title":"Vitamin B,2 absorption studies; comparison of \"7Co vitamin B1, plasma levels with and without parenteral vitamin B11","volume":"2","author":"Armstrong, B.K.; Woodliff, H.J.","year":"1969","unstructured":"Armstrong, B. K., and Woodliff, H. J. (1969). Vitamin B,2 absorption studies; comparison of \"7Co vitamin B1, plasma levels with and without parenteral vitamin B11. Med. J. Aust., 2, 692-693.","journal-title":"Med. J. Aust"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-2141.1956.tb06695.x","article-title":"Plasma, tissue and urinary radioactivity after oral administration of \"Co-labelled vitamin B1","volume":"2","author":"Booth, C.C.; Mollin, D.L.","year":"1956","unstructured":"Booth, C. C., and Mollin, D. L. (1956). Plasma, tissue and urinary radioactivity after oral administration of \"Co-labelled vitamin B1,. Brit. J. Haemat., 2, 223-236.","journal-title":"Brit. J. Haemat"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.5694\/j.1326-5377.1966.tb73202.x","article-title":"Plasma radioactivity after radioactive vitamin B1, given orally","volume":"1","author":"Coupland, W.W.","year":"1966","unstructured":"Coupland, W. W. (1966). Plasma radioactivity after radioactive vitamin B1, given orally. Med. J. Aust., 1, 1020-1023.","journal-title":"Med. J. Aust"},{"key":"ref_7","volume-title":"Studies in the Metabolism of Vitamin","author":"Doscherholmen, A.","year":"1965","unstructured":"Doscherholmen, A. (1965). Studies in the Metabolism of Vitamin"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/jcp.19.6.606","article-title":"Measurement of intestinal absorption of \"'Co vitamin B1, serum counting","volume":"19","author":"Forshaw, J.; Harwood, L.","year":"1966","unstructured":"Forshaw, J., and Harwood, L. (1966). Measurement of intestinal absorption of \"'Co vitamin B1, serum counting. J. clin. Path., 19, 606-609.","journal-title":"J. clin. Path"},{"key":"ref_9","first-page":"583","article-title":"Radioactive vitamin B,, studies: experience with the urinary excretion test and the measurement of absorbed plasma radioactivity","volume":"49","author":"Goldberg, S.R.; Trivedi, B.K.; Oliner, L.","year":"1957","unstructured":"Goldberg, S. R., Trivedi, B. K., and Oliner, L. (1957). Radioactive vitamin B,, studies: experience with the urinary excretion test and the measurement of absorbed plasma radioactivity. J. Lab. clin. Med., 49, 583-589.","journal-title":"J. Lab. clin. Med"},{"key":"ref_10","first-page":"167","article-title":"Measurement of plasma radioactivity following oral administration of \"'Co-labelled","volume":"9","author":"Kristensen, H. P. 0.; Hald, T","year":"1962","unstructured":"Kristensen, H. P. 0., and Hald, T. (1962). Measurement of plasma radioactivity following oral administration of \"'Co-labelled B,,. Dan. med. Bull., 9, 167-170.","journal-title":"B,,. Dan. med. Bull"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.7326\/0003-4819-62-1-97","article-title":"The detection of intestinal absorption of Co\" tagged vitamin B1, by serum counting","volume":"62","author":"McCurdy, P.R.","year":"1965","unstructured":"McCurdy, P. R. (1965). The detection of intestinal absorption of Co\" tagged vitamin B1, by serum counting. Ann. intern. Med., 62, 97-102.","journal-title":"Ann. intern. Med"},{"key":"ref_12","first-page":"966","article-title":"Comparison of the urinary excretion and 8 hour plasma tests for vitamin B,, absorption","volume":"68","author":"McIntyre, P.A.; Wagner, Jr, H.N.","year":"1966","unstructured":"McIntyre, P. A., and Wagner, H. N. Jr. (1966). Comparison of the urinary excretion and 8 hour plasma tests for vitamin B,, absorption. J. Lab. clin. Med., 68, 966-971.","journal-title":"J. Lab. clin. Med"},{"key":"ref_13","first-page":"158","article-title":"Single measurement of plasma radioactive vitamin B1, as a test for pernicious anaemia","volume":"61","author":"Nelp, W.B.; McAfee, J.G.; Wagner, Jr, H.N.","year":"1963","unstructured":"Nelp, W. B., McAfee, J. G., and Wagner, H. N. Jr. (1963). Single measurement of plasma radioactive vitamin B1, as a test for pernicious anaemia. J. Lab. clin. Med., 61, 158-165.","journal-title":"J. Lab. clin. Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.5694\/j.1326-5377.1966.tb73203.x","article-title":"Vitamin B,, absorption studies: comparison of 6\"Co vitamin B12 plasma levels, urinary excretion and faecal excretion","volume":"1","author":"Woodliff, H.J.; Armstrong, B.K.","year":"1966","unstructured":"Woodliff, H. J., and Armstrong, B. K. (1966). Vitamin B,, absorption studies: comparison of 6\"Co vitamin B12 plasma levels, urinary excretion and faecal excretion. Med. J. Aust., 1, 1023-1025.","journal-title":"Med. J. Aust"},{"key":"ref_15","first-page":"583","article-title":"Cobalt-57 labeled vitamin B,, plasma levels for the differential diagnosis of macroc tic anemias","volume":"7","author":"Workman, J.B.; Rusche, E.","year":"1966","unstructured":"Workman, J. B., and Rusche, E. (1966). Cobalt-57 labeled vitamin B,, plasma levels for the differential diagnosis of macroc tic anemias. J. nucl. Med., 7, 583-588.","journal-title":"J. nucl. 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