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Results intermediate between the sickle-cell trait and sickle-cell anaemia are obtained in unusual cases of sickle-cell anaemia with high foetal haemoglobin.<\/jats:p>\n               <jats:p>The need to supplement the results with haematological and electrophoretic techniques is discusses.<\/jats:p>","DOI":"10.1136\/jcp.23.9.781","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"781-783","source":"Crossref","is-referenced-by-count":23,"title":["A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia"],"prefix":"10.1136","volume":"23","author":[{"given":"R. G.","family":"Huntsman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. P. T.","family":"Barclay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Canning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. I.","family":"Yawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1970,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","DOI":"10.1136\/jcp.23.8.736","article-title":"Assessment of 'Sickledex': an alternative to the sickling test","author":"Canning, D.M.; Huntsman, R.G.","year":"1970","unstructured":"Canning, D. M., and Huntsman, R. G. (1970). Assessment of 'Sickledex': an alternative to the sickling test. J. clin. Path., in press.","journal-title":"J. clin. Path"},{"key":"ref_2","first-page":"1082","article-title":"A simple and rapid method for demonstrating sickling of the red blood cells: the use of reducing agents","volume":"33","author":"Daland, G.A.; Castle, W.B.","year":"1948","unstructured":"Daland, G. A., and Castle, W. B. (1948). A simple and rapid method for demonstrating sickling of the red blood cells: the use of reducing agents. J. Lab. clin. Med., 33, 1082-1088.","journal-title":"J. Lab. clin. Med"},{"key":"ref_3","article-title":"A new diagnostic test for haemoglobin S","author":"Diggs, L.W.; Schorr, J.B.; Ascari, W.Q.; Reiss, A.","year":"1968","unstructured":"Diggs, L. W., Schorr, J. B., Ascari, W. Q., and Reiss, A. (1968). A new diagnostic test for haemoglobin S. In Proc. Amer. Soc. clin. Path. and Coll. Amer. Path., 23rd Joint Annual Meeting, 1968.","journal-title":"In Proc. Amer. Soc. clin. Path. and Coll. Amer. Path., 23rd Joint Annual Meeting"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/clinchem\/4.2.146","article-title":"The ferrohemoglobin solubility test","volume":"4","author":"Goldberg, C.A.J.","year":"1958","unstructured":"Goldberg, C. A. J. (1958). The ferrohemoglobin solubility test. Clin. Chem., 4, 146-149.","journal-title":"Clin. Chem"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0003-9861(53)90444-5","article-title":"Solubilities of naturally occurring mixtures of human hemoglobin","volume":"47","author":"Itano, H.A.","year":"1953","unstructured":"Itano, H. A. (1953). Solubilities of naturally occurring mixtures of human hemoglobin. Arch. Biochem., 47, 148-159.","journal-title":"Arch. Biochem"},{"key":"ref_6","first-page":"16511652","article-title":"A new solubility test for rapid detection of hemoglobin S","volume":"61","author":"Loh, W.P.","year":"1968","unstructured":"Loh, W. P. (1968). A new solubility test for rapid detection of hemoglobin S. J. Indiana State med. Ass., 61, 16511652.","journal-title":"J. Indiana State med. Ass"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1001\/jama.1967.03130180085017","article-title":"Sickling tests: pitfalls in performance and interpretation","volume":"202","author":"Schneider, R.G.; Alperin, J.B.; Lehmann, H.","year":"1967","unstructured":"Schneider, R. G., Alperin, J. B., and Lehmann, H. (1967). Sickling tests: pitfalls in performance and interpretation. J. Amer. med. Ass., 202, 419-421.","journal-title":"J. Amer. med. Ass"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/bmj.3.5610.86","article-title":"Relatively benign sickle-ell anaemia in 60 patients aged over 30 in the West Indies","volume":"3","author":"Serjeant, G.R.; Richards, R.; Barbor, P.R.H.; Milner, P.F.","year":"1968","unstructured":"Serjeant, G. R., Richards, R., Barbor, P. R. H., and Milner, P. F. (1968). Relatively benign sickle-ell anaemia in 60 patients aged over 30 in the West Indies. Brit. med. J., 3, 86-91.","journal-title":"Brit. med. J"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.23.9.781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:01:17Z","timestamp":1758913277000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.23.9.781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,12]]},"references-count":8,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1970,12,1]]},"published-print":{"date-parts":[[1970,12]]}},"alternative-id":["10.1136\/jcp.23.9.781"],"URL":"https:\/\/doi.org\/10.1136\/jcp.23.9.781","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1970,12]]}}}