{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:26:34Z","timestamp":1763749594032,"version":"3.45.0"},"reference-count":0,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1971,2]]},"abstract":"<jats:p>\n                    The antibiotic resistance of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    isolated in Bristol from primary skin sepsis and nasal carriers outside hospital was recorded between 1949 and 1969. The proportion of penicillinase-forming strains rose to about 60% but resistance to other antibiotics remained un-common except for a peak about 1957, due to the spread of multiresistant phage-type 80 staphylococci. Reasons are discussed for the failure of other multiresistant staphylococci to increase outside hospital.\n                  <\/jats:p>\n                  <jats:p>Recently isolated strains from inside and outside hospital were tested with sulphonamide and trimethoprim. All were sensitive to trimethoprim but 5% of non-hospital strains and 40% of hospital strains were resistant to sulphonamide. It is suggested that sulphonamide-resistant staphylococcal infections should not be treated with sulphonamide-trimethoprim mixtures because of the risk of breeding trimethoprim-resistant strains.<\/jats:p>","DOI":"10.1136\/jcp.24.1.44","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"44-47","source":"Crossref","is-referenced-by-count":15,"title":["Changes in the drug resistance of\n                    <i>Staphylococcus aureus<\/i>\n                    in a non-hospital population during a 20-year period"],"prefix":"10.1136","volume":"24","author":[{"given":"D. J.","family":"Goldie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. G.","family":"Alder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. A.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1971,2,1]]},"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.24.1.44","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:08:52Z","timestamp":1763748532000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.24.1.44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,2]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1971,2,1]]},"published-print":{"date-parts":[[1971,2]]}},"alternative-id":["10.1136\/jcp.24.1.44"],"URL":"https:\/\/doi.org\/10.1136\/jcp.24.1.44","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1971,2]]}}}