{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:54:27Z","timestamp":1765727667197,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1971,12]]},"abstract":"<jats:p>Complement-fixing antibodies against an antigen prepared from the EB3 line of cultured Burkitt tumour cells were studied in various groups of patients and control individuals. Higher antibody titres were observed in patients with Burkitt's tumour than in African patients with other diagnoses. Significantly more medical students and nurses with a history of infectious mononucleosis possessed antibodies than those with no such history. Low levels of antibody were observed in patients during the acute phase of infectious mononucleosis and these levels were significantly lower than those in patients admitted to the same hospital with other diagnoses.<\/jats:p>\n                  <jats:p>During the early months following the acute phase of illness, EB complement-fixing antibodies remained stationary or apparently declined in titre but, in patients tested one or more years later, significantly higher antibody levels were observed.<\/jats:p>","DOI":"10.1136\/jcp.24.9.801","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"801-804","source":"Crossref","is-referenced-by-count":10,"title":["Some observations on complement-fixing antibodies to the EB virus"],"prefix":"10.1136","volume":"24","author":[{"given":"R. N. P.","family":"Sutton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Marston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T. D.","family":"Emond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1971,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1128\/JB.91.3.1257-1262.1966","article-title":"Complementfixation tests with cell lines derived from Burkitt's lymphoma and acute leukaemias","volume":"91","author":"Armstrong, D.; Henle, G.; Henle, W.","year":"1966","unstructured":"Armstrong, D., Henle, G., and Henle, W. (1966). Complementfixation tests with cell lines derived from Burkitt's lymphoma and acute leukaemias. J. Bact., 91, 1257-1262.","journal-title":"J. Bact"},{"key":"ref_2","first-page":"593","article-title":"Specific immunofluorescence test for the herpes-type EB virus of Burkitt lymphoblasts, authenticated by electron microscopy","volume":"40","author":"Epstein, M.A.; Achong, B.G.","year":"1968","unstructured":"Epstein, M. A., and Achong, B. G. (1968). Specific immunofluorescence test for the herpes-type EB virus of Burkitt lymphoblasts, authenticated by electron microscopy. J. nat. Cancer Inst., 40, 593-607.","journal-title":"J. nat. Cancer Inst"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0140-6736(64)91524-7","article-title":"Virus particles in cultured lymphoblasts fiom Burkitt's lymphoma","volume":"1","author":"Epstein, M.A.; Achong, B.G.; Barr, Y.M.","year":"1964","unstructured":"Epstein, M. A., Achong, B. G., and Barr, Y. M. (1964). Virus particles in cultured lymphoblasts fiom Burkitt's lymphoma. Lancet, 1, 702-703.","journal-title":"Lancet"},{"key":"ref_4","first-page":"69","article-title":"Studies with Burkitt's lymphoma. In Methodological Approaches to the Study of Leukaemia (Wistar Institute Symposium Monograph No","volume":"pp,","author":"Epstein, M.A.; Barr, Y.M.; Achong, B.G.","year":"1965","unstructured":"Epstein, M. A., Barr, Y. M., and Achong, B. G. (1965). Studies with Burkitt's lymphoma. In Methodological Approaches to the Study of Leukaemia (Wistar Institute Symposium Monograph No. 4) pp, 69-82. Wistar Institute Press, Philadelphia."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1073\/pnas.58.2.478","article-title":"Complement-fixing antibodies in sera of human and nonhuman primates to viral antigens derived from Burkitt's lvmphoma cells","volume":"58","author":"Gerber, P.; Birch, S.M.","year":"1967","unstructured":"Gerber, P., and Birch, S. M. (1967). Complement-fixing antibodies in sera of human and nonhuman primates to viral antigens derived from Burkitt's lvmphoma cells. Proc. nat. Acad. Sci. (Wash.), 58, 478-484.","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"ref_6","first-page":"\"830","article-title":"Comparative study of cultured Burkitt tumor cells by immunofluorescence, autoradiography and electron microscopy","volume":"1","author":"Hausen, H.zur; Henle, W.; Hummeler, K.; Diehl, V.; Henle, G.","year":"1967","unstructured":"Hausen, H. zur., Henle, W., Hummeler, K., Diehl, V., and Henle, G. (1967). Comparative study of cultured Burkitt tumor cells by immunofluorescence, autoradiography and electron microscopy. J. Virol., 1, 830-837. Henl2, G., and Henle, W. (1966). Immunofluorescence in cells derived from Burkitt's lymphoma. J. Bact., 91, 1248-1256.","journal-title":"J. Virol; Immunofluorescence in cells derived from Burkitt's lymphoma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1073\/pnas.59.1.94","article-title":"Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis","volume":"59","author":"Henle, G.; Henle, W.; Diehl, V.","year":"1968","unstructured":"Henle, G., Henle, W., and Diehl, V. (1968). Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis. Proc. nat. Acad. Sci. (Wash.), 59, 94-101.","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/jama.1968.03140030037009","article-title":"Infectious mononucleosis: clinical manifestations in relation to EB virus antibodies","volume":"203","author":"Niederman, J.C.; McCollum, R.W.; Henle, G.; Henle, W.","year":"1968","unstructured":"Niederman, J. C., McCollum, R. W., Henle, G., and Henle, W. (1968). Infectious mononucleosis: clinical manifestations in relation to EB virus antibodies. J. Amer. med. Ass., 203, 205-209.","journal-title":"J. Amer. med. Ass"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1073\/pnas.56.6.1699","article-title":"Precipitating antibody in human serum to an antigen present in cultured Burkitt's lymphoma cells","volume":"56","author":"Old, L.J.; Boyse, E.A.; Oettgen, H.F.; Harven, E.de; Geering, G.; Williamson, B.; Clifford, P.","year":"1966","unstructured":"Old, L. J., Boyse, E. A., Oettgen, H. F., Harven, E. de, Geering, G., Williamson, B., and Clifford, P. (1966). Precipitating antibody in human serum to an antigen present in cultured Burkitt's lymphoma cells. Proc. nat. Acad. Sci. (Was\/i.), 56, 1699-1704.","journal-title":"Proc. nat. Acad. Sci. (Was\/i.)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/222186a0","article-title":"Significance of a complement-fixing antigen associated with herpes-like virus and detected in the Raji cell line","volume":"222","author":"Pope, J.H.; Horne, M.K.; Wetters, E.J.","year":"1969","unstructured":"Pope, J. H., Horne, M. K., and Wetters, E. J. (1969). Significance of a complement-fixing antigen associated with herpes-like virus and detected in the Raji cell line. Nature (Lond.), 222, 186-187.","journal-title":"Nature (Lond.)"},{"key":"ref_11","article-title":"Utilization of disposable plastic plates, with a serologic microtechnic. Amtler","author":"Sever, J.L.; Lev, A.C.; Wolman, F.; Caplan, B.M.; Pernell, W.; Crockett, B.S.; Turner, H.C.","year":"1964","unstructured":"Sever, J. L., Lev, A. C., Wolman, F., Caplan, B. M., Pernell, W., Crockett, B. S., and Turner, H. C. (1964). Utilization of disposable plastic plates, with a serologic microtechnic. Amtler."},{"issue":"19","key":"ref_12","first-page":"1","article-title":"The use of spiral loops in serological and virological micro-methods","volume":"3","author":"Takatsy, G.","year":"1953","unstructured":"Takatsy, G. (1953). The use of spiral loops in serological and virological micro-methods. Acta inicrobiol. Acad. Sci. hunig., 3, 19 1-202.","journal-title":"Acta inicrobiol. Acad. 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