{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:45:27Z","timestamp":1765007127310,"version":"3.46.0"},"reference-count":26,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1971,12]]},"abstract":"<jats:p>A patient with hyperparathyroidism due to a parathyroid adenoma was found to have metastatic medullary carcinoma in lymph nodes close to the thyroid gland. The finding of normal calcitonin and parathormone concentrations after removal of the adenoma suggested that the parathyroid lesion was not the result of the hypocalcaemic action of calcitonin produced by the tumour in the thyroid.<\/jats:p>\n                  <jats:p>Seventeen other examples of the association between medullary carcinoma and parathyroid enlargement are briefly reviewed.<\/jats:p>\n                  <jats:p>The pathogenesis of the parathyroid lesions is discussed, and it is suggested that some may be caused by the hypocalcaemic action of calcitonin, while others may be part of a syndrome of multiple endocrine adenomatosis.<\/jats:p>","DOI":"10.1136\/jcp.24.9.851","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"851-855","source":"Crossref","is-referenced-by-count":3,"title":["Medullary carcinoma of the thyroid with parathyroid adenoma and hypercalcaemia"],"prefix":"10.1136","volume":"24","author":[{"given":"J. B.","family":"MacGillivray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J. B.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1971,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/ajcp\/53.5.565","article-title":"The surgical pathology of parathyroid chief cell hyperplasia","volume":"53","author":"Black, W.C.; Haff, R.C.","year":"1970","unstructured":"Black, W. C., and Haff, R. C. (1970). The surgical pathology of parathyroid chief cell hyperplasia. Amer. J. clin. Path., 53, 565-579.","journal-title":"Amer. J. clin. Path"},{"key":"ref_2","first-page":"63","article-title":"A calcitonin-secreting thyroid carcinoma","volume":"2","author":"Cunliffe, W.J.; Black, M.M.; Hall, R.; Johnston, I.D.A.; Hudgson, P.; Shuster, S.; Gudmundsson, T.V.; Joplin, G.F.; Williams, E.D.; Woodhouse, N.J.Y.; Galante, L.; Maclntyre, I.","year":"1968","unstructured":"Cunliffe, W. J., Black, M. M., Hall, R., Johnston, I. D. A., Hudgson, P., Shuster, S., Gudmundsson, T. V., Joplin, G. F., Williams, E. D., Woodhouse, N. J. Y., Galante, L., and Maclntyre, I. (1968). A calcitonin-secreting thyroid carcinoma. Lancet, 2, 63-66.","journal-title":"Lancet"},{"key":"ref_3","first-page":"352","article-title":"Familial endocrine tumours. Report of two unrelated kindred affected with pheochromocytomas, one also with multiple thyroid carcinomas","volume":"32","author":"Cushman, Jr, P.","year":"1962","unstructured":"Cushman, P., Jr. (1962). Familial endocrine tumours. Report of two unrelated kindred affected with pheochromocytomas, one also with multiple thyroid carcinomas. Amer. J. Med., 32, 352-360.","journal-title":"Amer. J. Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/bmj.3.5615.395","article-title":"Tertiary hyperparathyroidism","volume":"3","author":"Davies, D.R.; Dent, C.E.; Watson, L.","year":"1968","unstructured":"Davies, D. R., Dent, C. E., and Watson, L. (1968). Tertiary hyperparathyroidism. Brit. med. J., 3, 395-399.","journal-title":"Brit. med. J"},{"key":"ref_5","first-page":"76","article-title":"Multiple endocrine tumours. Report of an unusual triad in a family","author":"Finegold, M.J.; Haddad, J.R.","year":"1963","unstructured":"Finegold, M. J., and Haddad, J. R. (1963). Multiple endocrine tumours. Report of an unusual triad in a family. Arch. Path., 76,449-455.","journal-title":"Arch. Path"},{"key":"ref_6","first-page":"575","article-title":"Medullary carcinoma of the thyroid gland: a clinicopathological study of 33 patients","volume":"80","author":"Freeman, D.; Lindsay, S.","year":"1965","unstructured":"Freeman, D., and Lindsay, S. (1965). Medullary carcinoma of the thyroid gland: a clinicopathological study of 33 patients. Arch. Path., 80, 575-582.","journal-title":"Arch. Path"},{"key":"ref_7","article-title":"Personal communication","author":"Galante, L.","year":"1971","unstructured":"Galante, L. (1971). Personal communication."},{"year":"1968","author":"Gonzalez-Licea, A.; Hartmann, W.H.; Yardley, J.H.","key":"ref_8","unstructured":"Gonzalez-Licea, A., Hartmann, W. H., and Yardley, J. H. (1968)."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/1097-0142(1967)20:5<706::AID-CNCR2820200523>3.0.CO;2-M","article-title":"Solid carcinoma of the thyroid gland. Analysis of 53 cases","volume":"20","author":"Ibanez, M.L.; Cole, V.W.; Russell, W.O.; Clark, R.L.","year":"1967","unstructured":"Ibanez, M. L., Cole, V. W., Russell, W. O., and Clark, R. L. (1967). Solid carcinoma of the thyroid gland. Analysis of 53 cases. Cancer (Philad.), 20, 706-723.","journal-title":"Cancer (Philad.)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1056\/NEJM196301102680202","article-title":"Pheochromocytoma, hyperparathyroidism and thyroid carcinoma occurring coincidentally. Report of a case","volume":"268","author":"Manning, Jr., P.C.; Molnar, G.D.; Black, B.M.; Priestley, J.T.; Woolner, L.B.","year":"1963","unstructured":"Manning, P. C., Jr., Molnar, G. D., Black, B. M., Priestley, J. T., and Woolner, L. B. (1963). Pheochromocytoma, hyperparathyroidism and thyroid carcinoma occurring coincidentally. Report of a case. New Engi. J. Med., 268, 68-72.","journal-title":"New Engi. J. 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(Wash.), 59, 1216-1222.","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJM196507292730504","article-title":"'Malignant carcinoid syndrome' associated with noncarcinoid tumors","volume":"273","year":"1965","unstructured":"Moertel, C. G., Beahrs, 0. H., Woolner, L. B., and Tyce, G. M. (1965). 'Malignant carcinoid syndrome' associated with noncarcinoid tumors. New Engl. J. Med., 273, 244-248.","journal-title":"New Engl. J. Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1001\/jama.1966.03100260045014","article-title":"The diagnosis of pheochromocytoma. Analysis of 26 cases","volume":"196","author":"Moorhead, E.L.; Caldwell, J.R.; Kelly, A.R.; Morales, A.R.","year":"1966","unstructured":"Moorhead, E. L., Caldwell, J. R., Kelly, A. R., and Morales, A. R. (1966). The diagnosis of pheochromocytoma. Analysis of 26 cases. J. Amer. med. Ass., 196, 1107-1113.","journal-title":"J. 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A possible regulatory defect in the differentiation of chromaffin tissue","volume":"279","author":"Schimke, R.N.; Hartmann, W.H.; Prout, T.E.; Rimoin, D.L.","year":"1968","unstructured":"Schimke, R. N., Hartmann, W. H., Prout, T. E., and Rimoin, D. L. (1968). Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue. New Engl. J. Med., 279, 1-7.","journal-title":"New Engl. J. Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0002-9343(61)90234-0","article-title":"The association of pheochromocytoma with carcinoma of the thyroid gland","volume":"31","author":"Sipple, J.H.","year":"1961","unstructured":"Sipple, J. H. (1961). The association of pheochromocytoma with carcinoma of the thyroid gland. Amer. J. Med., 31, 163-166.","journal-title":"Amer. J. Med"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00005792-196809000-00001","article-title":"Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: multiple endocrine neoplasia, type 2","volume":"47","author":"Steiner, A.L.; Goodman, A.D.; Powers, S.R.","year":"1968","unstructured":"Steiner, A. L., Goodman, A. D., and Powers, S. R. (1968). Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: multiple endocrine neoplasia, type 2. Medicine (Baltimore), 47, 371-409.","journal-title":"Medicine (Baltimore)"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1056\/NEJM197010222831702","article-title":"Immunoassay of human calcitonin. Clinical measurement, relation to serum calcium and studies on patients with medullary carcinoma","volume":"283","author":"Tashjian, Jr., A.H.; Howland, B.G.; Melvin, K.E.W.; Hill, Jr, C.S.","year":"1970","unstructured":"Tashjian, A. H., Jr., Howland, B. G., Melvin, K. E. W., and Hill, C. S., Jr. (1970). Immunoassay of human calcitonin. Clinical measurement, relation to serum calcium and studies on patients with medullary carcinoma. New Engl. J. Med., 283, 890-895.","journal-title":"New Engl. J. Med"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0021-9681(67)90040-9","article-title":"Medullary thyroid carcinoma, parathyroid adenoma, and bilateral pheochromocytoma. An unusual triad of endocrine tumors","volume":"20","author":"Urbanski, F.X.","year":"1967","unstructured":"Urbanski, F. X. (1967). Medullary thyroid carcinoma, parathyroid adenoma, and bilateral pheochromocytoma. An unusual triad of endocrine tumors. J. chron. Dis., 20, 627-636.","journal-title":"J. chron. Dis"},{"key":"ref_21","first-page":"232","article-title":"The neural ectodermal origin of the peptide secreting endocrine glands: a unifying concept for the etiology of multiple endocrine adenomatosis and the inappropriate secretion of peptide hormones by neoendocrine tumors","volume":"49","author":"Weichert, R.F.; lI","year":"1970","unstructured":"Weichert, R. F., lI. (1970). The neural ectodermal origin of the peptide secreting endocrine glands: a unifying concept for the etiology of multiple endocrine adenomatosis and the inappropriate secretion of peptide hormones by neoendocrine tumors. Amer. J. Med., 49, 232-241.","journal-title":"Amer. J. Med"},{"key":"ref_22","article-title":"Medullary carcinoma of thyroid. In Symposium on the Thyroid Gland","author":"Williams, E.D.","year":"1967","unstructured":"Williams, E. D. (1967). Medullary carcinoma of thyroid. In Symposium on the Thyroid Gland. J. clin. Path. Suppl. (Ass. Clin. Path.).","journal-title":"J. clin. Path. Suppl"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/jcp.19.2.103","article-title":"Pathological and clinical findings in a series of 67 cases of medullary carcinoma of the thyroid gland","volume":"19","author":"Williams, E.D.; Brown, C.L.; Doniach, I.","year":"1966","unstructured":"Williams, E. D., Brown, C. L., and Doniach, I. (1966). Pathological and clinical findings in a series of 67 cases of medullary carcinoma of the thyroid gland. J. clin. Path., 19, 103-113.","journal-title":"J. clin. Path"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/jcp.21.2.129","article-title":"Thyroid carcinoma and Cushing's syndrome: a report of two cases with a review of the common features of the 'non-endocrine' tumours associated with Cushing's syndrome","volume":"21","author":"Williams, E.D.; Morales, A.M.; Horn, R.C.","year":"1968","unstructured":"Williams, E. D., Morales, A. M., and Horn, R. C. (1968). Thyroid carcinoma and Cushing's syndrome: a report of two cases with a review of the common features of the 'non-endocrine' tumours associated with Cushing's syndrome. J. clin. Path., 21, 129-135.","journal-title":"J. clin. Path"},{"key":"ref_25","article-title":"Since the manuscript","volume-title":"have reported 11 members of a family with medullary carcinoma of the thyroid who had raised plasma calcitonin levels after calcium infusion. Chief cell hyperplasia was found in nine cases. All were normocalcaemic but in six cases the plasma parathormone level was raised","author":"Melvin, Miller; Tashjian","year":"1971","unstructured":"Since the manuscript was submitted Melvin, Miller, and Tashjian (1971) have reported 11 members of a family with medullary carcinoma of the thyroid who had raised plasma calcitonin levels after calcium infusion. Chief cell hyperplasia was found in nine cases. All were normocalcaemic but in six cases the plasma parathormone level was raised."},{"key":"ref_26","first-page":"11151120","article-title":"Early diagnosis of medullary carcinoma of the thyroid gland by means of calcitonin assay","volume":"285","author":"Melvin, R.E.W.; Miller, H.H.; Tashjian, Jr, A.H.","year":"1971","unstructured":"Melvin, R. E. W., Miller, H. H., and Tashjian, A. H., Jr. (1971). Early diagnosis of medullary carcinoma of the thyroid gland by means of calcitonin assay. New Engl. J. Med., 285, 11151120.","journal-title":"New Engl. J. Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.24.9.851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:43:24Z","timestamp":1765007004000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.24.9.851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,12]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1971,12,1]]},"published-print":{"date-parts":[[1971,12]]}},"alternative-id":["10.1136\/jcp.24.9.851"],"URL":"https:\/\/doi.org\/10.1136\/jcp.24.9.851","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1971,12]]}}}