{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:51:43Z","timestamp":1777542703370,"version":"3.51.4"},"reference-count":41,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1972,10]]},"abstract":"<jats:p>Three series of patients shown to be euthyroid but originally referred for thyroid uptake tests <jats:italic>in vivo<\/jats:italic> have been compared.<\/jats:p>\n               <jats:p>In 1958-59, the `normal' mean thyroid uptake was 23\u00b75% and 38\u00b72% respectively at four and 24 hours. By 1967, the mean uptakes had dropped to 20\u00b74% and 31\u00b76%\u2014a significant change at both times. By 1972 there was, however, no sign of a further reduction of the mean normal values for thyroid uptake.<\/jats:p>\n               <jats:p>These results are compared with changes observed in other series in the USA and elsewhere.<\/jats:p>","DOI":"10.1136\/jcp.25.10.863","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"863-866","source":"Crossref","is-referenced-by-count":16,"title":["Changes in the normal range of thyroidal radioiodine uptake"],"prefix":"10.1136","volume":"25","author":[{"given":"D. H.","family":"Keeling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/jcp.24.3.187","article-title":"The interpretation of the serum protein-bound iodine: a review","volume":"24","author":"Acland, J.D.","year":"1971","unstructured":"Acland, J. D. (1971). The interpretation of the serum protein-bound iodine: a review. J. clin. Path., 24, 187-218.","journal-title":"J. clin. Path"},{"key":"ref_2","first-page":"745","article-title":"Cervical iodine test: alteration of protein-bound iodine and radioactive iodine uptake determinations","volume":"36","author":"Baden, W.F.; Thompson, J.Q.; Walker, T.A.; Ardjomand, M.","year":"1970","unstructured":"Baden, W. F., Thompson, J. Q., Walker, T. A., and Ardjomand, M. (1970). Cervical iodine test: alteration of protein-bound iodine and radioactive iodine uptake determinations. Obstet. and Gynaec. 36, 745-747.","journal-title":"Obstet. and Gynaec"},{"key":"ref_3","first-page":"449","article-title":"Low normal ranges for the radioiodine uptake study","volume":"11","author":"Bernard, J.D.; McDonald, R.A.; Nesmith, J.A.","year":"1970","unstructured":"Bernard, J. D., McDonald, R. A., and Nesmith, J. A. (1970). Low normal ranges for the radioiodine uptake study. J. nucl. Med., 11, 449-451.","journal-title":"J. nucl. Med"},{"key":"ref_4","first-page":"743","article-title":"Lower normal values for 131-I thyroid uptake not related to the ingestion of white bread","volume":"12","author":"Blum, M.; Chandra, R.","year":"1971","unstructured":"Blum, M., and Chandra, R. (1971). Lower normal values for 131-I thyroid uptake not related to the ingestion of white bread. J. nucl. Med., 12, 743-745.","journal-title":"J. nucl. Med"},{"key":"ref_5","first-page":"489","article-title":"Goitre prophylaxis by addition of potassium iodate to bread: experience in Tasmania","volume":"1","author":"Clements, F.W.; Gibson, H.B.; Howeler-Coy, J.F.","year":"1970","unstructured":"Clements, F. W., Gibson, H. B., and Howeler-Coy, J. F. (1970). Goitre prophylaxis by addition of potassium iodate to bread: experience in Tasmania. Lancet, 1, 489-492.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.5694\/j.1326-5377.1971.tb87752.x","article-title":"Seasonal variation in thyroid function","volume":"1","author":"Connolly, R.J.","year":"1971","unstructured":"Connolly, R. J. (1971a). Seasonal variation in thyroid function. Med. J. Aust., 1, 633-636.","journal-title":"Med. J. Aust"},{"key":"ref_7","first-page":"1191","volume":"2","author":"Connolly, R.J.(1971b) Thechangingiodineenvironment of Tasmania Med J.","unstructured":"Connolly, R.J.(1971b). Thechangingiodineenvironment of Tasmania. Med. J. Aust., 2, 1191-1193.","journal-title":"Aust"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0022-3999(66)90065-1","article-title":"Some aspects of the diagnosis of thyrotoxicosis","volume":"10","author":"Crown, S.; Crisp, A.H.; Ellis, J.P.","year":"1966","unstructured":"Crown, S., Crisp, A. H., and Ellis, J. P. (1966). Some aspects of the diagnosis of thyrotoxicosis. J. Psychosomat. Res., 10, 209-214.","journal-title":"J. Psychosomat. Res"},{"key":"ref_9","first-page":"253","article-title":"The sensitive and precise measurement of serum thyroxine by saturation analysis (competitive protein binding assay)","volume":"2","author":"Ekins, R.P.; Williams, E.S.; Ellis, S.M.","year":"1969","unstructured":"Ekins, R. P., Williams, E. S., and Ellis, S. M. (1969). The sensitive and precise measurement of serum thyroxine by saturation analysis (competitive protein binding assay). Clin. Biochem., 2, 253-288.","journal-title":"Clin. Biochem"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1210\/jcem-32-2-254","article-title":"Adaptation of thyroid function to iodine intake in Buenos Aires","volume":"32","author":"Forcher, H.M.; Lanaro, A.E.; Enriori, C.L.; Reforzo-Membrives, J.","year":"1971","unstructured":"Forcher, H. M., Lanaro, A. E., Enriori, C. L., and Reforzo-Membrives, J. (1971). Adaptation of thyroid function to iodine intake in Buenos Aires. J. clin. Endocr., 32, 254-259.","journal-title":"J. clin. Endocr"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jama.1971.03190030061017","article-title":"New normal values for thyroid uptake of radioactive iodine","volume":"217","author":"Ghahremani, G.G.; Hoffer, P.B.; Oppenheim, B.E.; Gottschalk, A.","year":"1971","unstructured":"Ghahremani, G. G., Hoffer, P. B., Oppenheim, B. E., and Gottschalk, A. (1971). New normal values for thyroid uptake of radioactive iodine. J. Amer. med. Ass., 217, 337-339.","journal-title":"J. Amer. med. Ass"},{"key":"ref_12","first-page":"256","article-title":"The minimum dose of potassium iodide which inhibits the thyroidal radioiodine uptake","volume":"5","author":"Koutras, D.A.; Livadas, D.","year":"1966","unstructured":"Koutras, D. A., and Livadas, D. (1966). The minimum dose of potassium iodide which inhibits the thyroidal radioiodine uptake. Nuclearmedizin, 5, 256-261.","journal-title":"Nuclearmedizin"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1056\/NEJM196508122730708","article-title":"Breada dietary source of large quantities of iodine","volume":"273","author":"London, W.T.; Vought, R.L.; Brown, F.A.","year":"1965","unstructured":"London, W. T., Vought, R. L., and Brown, F. A. (1965). Breada dietary source of large quantities of iodine. New Engl. J. Med., 273, 381.","journal-title":"New Engl. J. 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