{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:50:23Z","timestamp":1765695023944,"version":"3.48.0"},"reference-count":16,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1972,11]]},"abstract":"<jats:p>Lipofuscins are commonly present in the macrophages of the marrow. In unstained preparations they may be confused with haemosiderin, but they are readily distinguished by fluorescence microscopy.<\/jats:p>\n                  <jats:p>In contrast to the belief that lipofuscins are a manifestation of senility, no age dependence has been demonstrated.<\/jats:p>\n                  <jats:p>Exceptionally large amounts have been found in illnesses accompanied by fever and leucocytosis, in keeping with the concept of their formation from insoluble remains of ingested cell fragments. It is probable that the `sea-blue histiocytes', described in the literature, are macrophages laden with strikingly uniform granules of lipofuscin.<\/jats:p>","DOI":"10.1136\/jcp.25.11.947","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"947-950","source":"Crossref","is-referenced-by-count":7,"title":["Bone marrow lipofuscin"],"prefix":"10.1136","volume":"25","author":[{"given":"K. G. A.","family":"Clark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(72)90553-3","article-title":"Syndrome of the sea-blue histiocyte","volume":"1","author":"Ardeman, S.; Lewis, J.G.","year":"1972","unstructured":"Ardeman, S., and Lewis, J. G. (1972). Syndrome of the sea-blue histiocyte. Lancet, 1, 797.","journal-title":"Lancet"},{"key":"ref_2","first-page":"9","article-title":"Iron Metabolism","author":"Bothwell, T. 14.; Finch, C. A","year":"1962","unstructured":"Bothwell, T. 14., and Finch, C. A. (1962). Iron Metabolism, p. 9. 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Pathol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0022-5320(60)90016-2","article-title":"Human hepatocellular pigments and lysosomes","volume":"3","author":"Essner, E.; Novikoff, A.B.","year":"1960","unstructured":"Essner, E., and Novikoff, A. B. (1960). Human hepatocellular pigments and lysosomes. J. LItrastruct. Res., 3, 374-391.","journal-title":"J. LItrastruct. Res"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1083\/jcb.42.1.253","article-title":"Lipofuscin (ageing) pigment granules of the newborn human liver","volume":"42","author":"Goldfischer, S.; Bernstein, J.","year":"1969","unstructured":"Goldfischer, S., and Bernstein, J. (1969). Lipofuscin (ageing) pigment granules of the newborn human liver. J. Cell Biol., 42, 253-261.","journal-title":"J. Cell Biol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1056\/NEJM197003122821120","article-title":"Sea blue indigestion","volume":"282","author":"Kattlove, H.E.; Gaynor, E.; Spivack, M.; Gottfreid, E.L.","year":"1970","unstructured":"Kattlove, H. E., Gaynor, E., Spivack, M., and Gottfreid, E. L. (1970). Sea blue indigestion. New Engl. J. Med., 282, 630.","journal-title":"New Engl. J. Med"},{"key":"ref_10","first-page":"33","article-title":"Histopathologic Technic and Practical Histochenmistry","author":"Lillie, R.D.","year":"1965","unstructured":"Lillie, R. D. (1965). Histopathologic Technic and Practical Histochenmistry, 3rd ed. McGraw-Hill, New York. Rath, C. E., and Finch, C. A. (1948). Sternal marrow hemosiderin. A method for the determination of available iron stores in man. J. Lab. clin. Med., 33,81-86.","edition":"3rd ed","journal-title":"J. Lab. clin. Med; Sternal marrow hemosiderin. A method for the determination of available iron stores in man"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/geronj\/23.2.145","article-title":"Lipofuscin pigment accumulation and distribution in five rat organs as a function of age","volume":"23","author":"Reichel, W.","year":"1968","unstructured":"Reichel, W. (1968). Lipofuscin pigment accumulation and distribution in five rat organs as a function of age. J. Gerontol., 23, 145-153.","journal-title":"J. Gerontol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/geronj\/23.1.71","article-title":"Lipofuscin pigment accumulation as a function of age, and distribution in rodent brain","volume":"23","author":"Reichel, W.; Hollander, J.; Clark, J.H.; Strehler, B.L.","year":"1968","unstructured":"Reichel, W., Hollander, J., Clark, J. H., and Strehler, B. L. (1968). Lipofuscin pigment accumulation as a function of age, and distribution in rodent brain. J. Gerontol., 23, 71-78.","journal-title":"J. Gerontol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197001012820101","article-title":"The syndrome of the sea blue histiocyte","volume":"282","author":"Silverstein, M.N.; Ellefson, R.D.; Ahern, E.J.","year":"1970","unstructured":"Silverstein, M. N., Ellefson, R. D., and Ahern, E. J. (1970). The syndrome of the sea blue histiocyte. New Engl. J. Med., 282, 1-4.","journal-title":"New Engl. J. Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1001\/archinte.1964.03860080101010","article-title":"Splenomegaly with rare morphologically distinct histiocytes","volume":"114","author":"Silverstein, M.N.; Young, D.G.; ReMine, W.H.; Pease, G.L.","year":"1964","unstructured":"Silverstein, M. N., Young, D. G., ReMine, W. H., and Pease, G. L. (1964). Splenomegaly with rare morphologically distinct histiocytes. Arch. intern. Med., 114, 251-257.","journal-title":"Arch. intern. 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