{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:00:41Z","timestamp":1765692041139,"version":"3.48.0"},"reference-count":25,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1972,2]]},"abstract":"<jats:p>\n                    One hundred and twenty-one rectal biopsies from 99 patients with carcinoma of the rectum or lower sigmoid colon were investigated using a high iron-diamine-Alcian blue technique for sulphated and non-sulphated acid mucins. It was found that in normal rectal mucosa sulphomucins are the main carbohydrate component of the goblet cell mucin. This normal `mucous pattern' changes in the `transitional' mucosa (histological normal mucosa adjacent to carcinoma) where there is an increase of non-sulphated acid mucins concomitantly with a decrease or absence of sulphated groups in 60 to 90% of the cases according to the type of tumour. The same type of changes in mucus were observed in the `transitional' mucosa surrounding adenomatous polyps and papillary adenomas; they were not marked in areas around carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    and not observed in the metaplastic polyps. These changes seem to be in direct relationship to the grade of differentiation and invasiveness of the tumour.\n                  <\/jats:p>\n                  <jats:p>The histochemical changes in the mucins seem to be in favour of a malignant potential in the so-called neoplastic polyps.<\/jats:p>\n                  <jats:p>The high iron diamine-Alcian blue, because of its `specificity', consistent results, and easy technique is recommended for routine use together with haematoxylin and eosin staining in the diagnosis of premalignant changes.<\/jats:p>","DOI":"10.1136\/jcp.25.2.123","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"123-128","source":"Crossref","is-referenced-by-count":52,"title":["The value of a study of the mucosubstances in rectal biopsies from patients with carcinoma of the rectum and lower sigmoid in the diagnosis of premalignant mucosa"],"prefix":"10.1136","volume":"25","author":[{"given":"M. Isabel","family":"Filipe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,2,1]]},"reference":[{"key":"ref_1","first-page":"5","article-title":"Malignant potential of polypoid lesions of the large intestine","volume":"32","author":"Ackerman, L.V.","year":"1964","unstructured":"Ackerman, L. V. (1964). Malignant potential of polypoid lesions of the large intestine. Trans. Stud. Coll. Phycns Philad., 32, 5-14.","journal-title":"Trans. Stud. Coll. Phycns Philad"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/003591576706000302","article-title":"Metachronous carcinoma of the large intestine and intestinal polyps","volume":"60","author":"Bussey, H.J.R.; Wallace, M.H.; Morson, B.C.","year":"1967","unstructured":"Bussey, H. J. R., Wallace, M. H., and Morson, B. C. (1967). Metachronous carcinoma of the large intestine and intestinal polyps. Proc. roy. Soc. 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