{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:44:26Z","timestamp":1790419466002,"version":"4.1.0"},"reference-count":16,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1972,6]]},"abstract":"<jats:p>The value of surface counting with <jats:sup>51<\/jats:sup>Cr-labelled red cells in predicting response to splenectomy in haemolytic anaemia has been analysed in 18 cases. The cases included six patients with congenital haemolytic anaemias, four with primary autoimmune haemolytic anaemias, and eight patients with secondary haemolytic anaemias (four with a positive antiglobulin test). All patients showed evidence of splenic accumulation of labelled cells and in 16 of the cases this was confined to the spleen. Improvement followed splenectomy in 17 of the cases although there was no close correlation between the magnitude of accumulation of radioactivity as measured by excess counts and the degree of response. The reasons for these discrepancies are discussed, The only patient who completely failed to respond to splenectomy had a sideroblastic element to the anaemia. It has been concluded that surface counting is of value in selecting patients for splenectomy but should not be depended upon without reference to other clinical and haematological factors, which are likely to influence the prognosis.<\/jats:p>","DOI":"10.1136\/jcp.25.6.467","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"467-472","source":"Crossref","is-referenced-by-count":19,"title":["Value of surface counting in predicting response to splenectomy in haemolytic anaemia"],"prefix":"10.1136","volume":"25","author":[{"given":"S.","family":"Ahuja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Szur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1972,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0002-9343(67)90168-4","article-title":"Idiopathic acquired autoimmune hemolytic anemia","volume":"43","author":"Allgood, J.W.; Chaplin, Jr, H.","year":"1967","unstructured":"Allgood, J. W., and Chaplin, H., Jr. (1967). Idiopathic acquired autoimmune hemolytic anemia. Amer. J. Med., 43, 254-273.","journal-title":"Amer. J. Med"},{"key":"ref_2","first-page":"832","article-title":"Sequestration studies with chromium-51 labeled red cells as criteria for splenectomy","volume":"3","author":"Ben-Bassat, I.; Seligsohn, U.; Leiba, H.; Leef, F.; Chaitchik, S.; Ramot, B.","year":"1967","unstructured":"Ben-Bassat, I., Seligsohn, U., Leiba, H., Leef, F., Chaitchik, S., and Ramot, B. (1967). Sequestration studies with chromium-51 labeled red cells as criteria for splenectomy. IsraelJ. med. Sci., 3, 832-837.","journal-title":"IsraelJ. med. Sci"},{"key":"ref_3","article-title":"Practical Haematology","author":"Dacie, J.V.; Lewis, S.M.","year":"1968","unstructured":"Dacie, J. V., and Lewis, S. M. (1968). Practical Haematology, 4th ed., Churchill, London.","edition":"4th ed"},{"key":"ref_4","first-page":"109","article-title":"Radiochromium in the selection of patients with haemolytic anaemia for splenectomy","volume":"1","author":"Goldberg, A.; Hutchinson, H.E.; MacDonald, E.","year":"1966","unstructured":"Goldberg, A., Hutchinson, H. E., and MacDonald, E. (1966). Radiochromium in the selection of patients with haemolytic anaemia for splenectomy. Lancet, 1, 109-114.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1365-2141.1964.tb00733.x","article-title":"The influence of anaemia, polycythaemia and splenomegaly on the relationship between venous haematocrit and red-cell volume","volume":"10","author":"Huber, H.; Lewis, S.M.; Szur, L.","year":"1964","unstructured":"Huber, H., Lewis, S. M., and Szur, L. (1964). The influence of anaemia, polycythaemia and splenomegaly on the relationship between venous haematocrit and red-cell volume. Brit. J. Haemat., 10, 567-575.","journal-title":"Brit. J. Haemat"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1172\/JCI103338","article-title":"Clinical determination of the sites of red cell sequestration in hemolytic anemias","volume":"35","author":"Jandi, J.H.; Greenberg, M.S.; Yonemoto, R.H.; Castle, W.B.","year":"1956","unstructured":"Jandi, J. H., Greenberg, M. S., Yonemoto, R. H., and Castle, W. B. (1956). Clinical determination of the sites of red cell sequestration in hemolytic anemias. J. clin. Invest., 35, 842-867.","journal-title":"J. clin. Invest"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2141.1957.tb05802.x","article-title":"Determination of the sites of red cell destruction using \"'Cr-labelled cells","volume":"3","author":"Jones, N.C.H.; Szur, L.","year":"1957","unstructured":"Jones, N. C. H., and Szur, L. (1957). Determination of the sites of red cell destruction using \"'Cr-labelled cells. Brit. J. Haemat., 3, 320-331.","journal-title":"Brit. J. Haemat"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2141.1960.tb06224.x","article-title":"The pattern of erythrocyte destruction in haemolytic anaemia, as studied with radioactive chromium","volume":"6","author":"Lewis, S.M.; Szur, L.; Dacie, J.V.","year":"1960","unstructured":"Lewis, S. M., Szur, L., and Dacie, J. V. (1960). The pattern of erythrocyte destruction in haemolytic anaemia, as studied with radioactive chromium. Brit. J. Haemat., 6, 122-139.","journal-title":"Brit. J. Haemat"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJM195809042591001","article-title":"Splenectomy in hemolytic anemias. Results predicted by body scanning after injection of \"lCr tagged red cells","volume":"259","author":"McCurdy, P.R.; Rath, C.E.","year":"1958","unstructured":"McCurdy, P. R., and Rath, C. E. (1958). Splenectomy in hemolytic anemias. Results predicted by body scanning after injection of \"lCr tagged red cells. New Engl. J. Med., 259, 459-463.","journal-title":"New Engl. J. Med"},{"key":"ref_10","article-title":"The spleen and anaemia","volume":"2","author":"Prankerd, T.A.J.","year":"1963","unstructured":"Prankerd, T. A. J. (1963). The spleen and anaemia. Brit. med. J., 2","journal-title":"Brit. med. 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Haemat"},{"key":"ref_13","first-page":"342","article-title":"Blood cell survival studies","volume-title":"Radioisotopes in Medical Diagnosis","author":"Szur, L.","year":"1971","unstructured":"Szur, L. (1971). Blood cell survival studies. In Radioisotopes in Medical Diagnosis, edited by E. H. Belcher and H. Vetter, pp. 342-382. Butterworths, London."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1259\/0007-1285-41-491-819","article-title":"Quantitative estimation of red cell uptake in the spleen using \"'Rb and \"'Cr labelled red cells","volume":"41","author":"Szur, L.; Glass, H.I.; Lewis, S.M.; Grammaticos, P.; De Garreta, A.C.","year":"1968","unstructured":"Szur, L., Glass, H. I., Lewis, S. M., Grammaticos, P., and De Garreta, A. C. (1968). Quantitative estimation of red cell uptake in the spleen using \"'Rb and \"'Cr labelled red cells. Brit. J. Radiol., 41, 819-825.","journal-title":"Brit. J. 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