{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:37:56Z","timestamp":1765600676311,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1972,7]]},"abstract":"<jats:p>A case of congenital dyserythropoietic anaemia with erythroblastic multinuclearity in a 36-year-old woman is described and the literature reviewed. The syndrome is characterized by a protracted clinical course, a relatively mild anaemia, a low reticulocyte count, slight hyperbilirubinaemia, splenomegaly, pronounced erythroid hyperplasia with reversal of the myeloid erythroid ratio, and in particular by the presence of multinucleated erythroblasts in the marrow. The picture of ineffective erythropoiesis is confirmed by erythrokinetic studies. The present case is the forty-first to be described in the literature and is the third from Britain. Thirty-one of these have occurred in seven families but a family history has been lacking in the remaining ten. The onset of anaemia occurred in childhood in 21 of the 41 cases.<\/jats:p>","DOI":"10.1136\/jcp.25.7.561","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"561-569","source":"Crossref","is-referenced-by-count":11,"title":["Congenital dyserythropoietic anaemia with erythroblastic multinuclearity"],"prefix":"10.1136","volume":"25","author":[{"given":"Malcolm","family":"Bright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Cobb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. E.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood.V19.3.296.296","article-title":"Hereditary benign erythroreticulosis","volume":"19","author":"Bergstrom, I.; Jacobsson, L.","year":"1962","unstructured":"Bergstrom, I., and Jacobsson, L. (1962). Hereditary benign erythroreticulosis. Blood, 19, 296-303.","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2141.1969.tb05660.x","article-title":"Hereditary erythroblastic multinuclearity associated with a positive acidified serum test: a type of congenital dyserythropoietic anaemia","volume":"17","author":"Crookston, J.H.; Crookston, M.C.; Burnie, L.K.Francombe; H., W.; Dacie, J.V.; Davis, J.A.; Lewis, S.M.","year":"1969","unstructured":"Crookston, J. H., Crookston, M. C., Burnie, L. K. Francombe, W. H., Dacie, J. V., Davis, J. A., and Lewis, S. M. (1969). Hereditary erythroblastic multinuclearity associated with a positive acidified serum test: a type of congenital dyserythropoietic anaemia. Brit. J. Huemat., 17, 11-26.","journal-title":"Brit. J. Huemat"},{"key":"ref_3","first-page":"186","article-title":"Practical Haenmatology","author":"Dacie, J.V.; Lewis, S.M.","year":"1968","unstructured":"Dacie, J. V., and Lewis, S. M. (1968). Practical Haenmatology, 4th ed., p. 186. Churchill, London.","edition":"4th ed"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0140-6736(62)92038-X","article-title":"Chromosomal study in erythroblastic endopolyploidy","volume":"1","author":"De Lozzio, C.B.; Valencia, J.I.; Acame, E.","year":"1962","unstructured":"De Lozzio, C. B., Valencia, J. I., and Acame, E. (1962). Chromosomal study in erythroblastic endopolyploidy. Lancet, 1, 1004-1005.","journal-title":"Lancet"},{"key":"ref_5","first-page":"174","volume":"215","author":"Heimpel, H.; Wendt, F.; Klemm, D.; Schubothe, H.; Heilmeyer, L.","year":"1968","unstructured":"Heimpel, H., Wendt, F., Klemm, D., Schubothe, H., and Heilmeyer, L. (1968). Kongenitale dyserythropoietische Anamie. Arch. k\/in. Med., 215, 174-194.","journal-title":"Kongenitale dyserythropoietische Anamie. Arch. k\/in. Med"},{"key":"ref_6","first-page":"103","article-title":"Congenital dyserythropoietic anemia with karyorrhexis and multinuclearity of erythroblasts","volume":"34","author":"Heimpel, H.; Wendt, F.","year":"1968","unstructured":"Heimpel, H., and Wendt, F. (1968). Congenital dyserythropoietic anemia with karyorrhexis and multinuclearity of erythroblasts. Helv. med. Acta, 34, 103-115.","journal-title":"Helv. med. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/S0140-6736(62)92228-6","article-title":"Haemolytic anaemia with multinucleated normoblasts in the marrow","volume":"1","author":"Roberts, P.D.; Wallis, P.G.; Jackson, A.D.M.","year":"1962","unstructured":"Roberts, P. D., Wallis, P. G., and Jackson, A. D. M. (1962). Haemolytic anaemia with multinucleated normoblasts in the marrow. Lancet, 1, 1186-1187.","journal-title":"Lancet"},{"key":"ref_8","first-page":"1511","article-title":"Konstitutionelle Anamie njit Kernteilungsstorung de Erythroblasten","volume":"44","author":"Scharer, K.; Marti, H.R.; Baumann, T.","year":"1965","unstructured":"Scharer, K., Marti, H. R., and Baumann, T. (1965). Konstitutionelle Anamie njit Kernteilungsstorung de Erythroblasten. Schweiz. med. Wschr., 44, 1511-1515.","journal-title":"Schweiz. med. Wschr"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2141.1969.tb05661.x","article-title":"Ineffective erythropoiesis with morphologically abnormal erythroblasts and unconjugated hyperbilirubinaemia","volume":"17","author":"Verwilghen, R.; Verhaegen, H.; Waumans, P.; Beert, J.","year":"1969","unstructured":"Verwilghen, R., Verhaegen, H., Waumans, P., and Beert, J. (1969). Ineffective erythropoiesis with morphologically abnormal erythroblasts and unconjugated hyperbilirubinaemia. Brit. J. Haemat., 17, 27-33.","journal-title":"Brit. J. Haemat"},{"key":"ref_10","first-page":"172","article-title":"Kongenitale dyserythropoetische Anamie bei einem zweieiigen zwillingspaar","volume":"62","author":"Wendt, Von F.; Heimpel, H.","year":"1967","unstructured":"Wendt, Von F., and Heimpel, H., (1967). Kongenitale dyserythropoetische Anamie bei einem zweieiigen zwillingspaar. Med. Klin., 62, 172-177.","journal-title":"Med. Klin"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1182\/blood.V6.12.1274.1274","article-title":"Familial erythroid multinuclearity","volume":"6","author":"Wolff, A.; Hofe, F.H.","year":"1951","unstructured":"Wolff, A., and Hofe, F. H. von (1951). Familial erythroid multinuclearity. Blood, 6, 1274-1283.","journal-title":"Blood"},{"key":"ref_12","article-title":"Since the manuscript was submitted the patient has been subjected to splenectomy","volume-title":"mainly because of the pain and discomfort attributed to the enlarged spleen. A liver biopsy was taken at the operation","year":"1972","unstructured":"Since the manuscript was submitted the patient has been subjected to splenectomy (on 1 June 1972) mainly because of the pain and discomfort attributed to the enlarged spleen. A liver biopsy was taken at the operation."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.25.7.561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:35:05Z","timestamp":1765600505000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.25.7.561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,7]]},"references-count":12,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1972,7,1]]},"published-print":{"date-parts":[[1972,7]]}},"alternative-id":["10.1136\/jcp.25.7.561"],"URL":"https:\/\/doi.org\/10.1136\/jcp.25.7.561","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1972,7]]}}}