{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:13:42Z","timestamp":1756995222918},"reference-count":0,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1973,1]]},"abstract":"<jats:p>The cytochemical methods for lysozyme and nitroblue-tetrazolium reduction have been used to study the blast cells of acute myeloid leukaemia. Both proved useful in characterizing the cases with predominant monocytic differentiation.<\/jats:p><jats:p>The demonstration of lysozyme activity helped to define two main groups: (a) with predominantly lysozyme-negative cells (myeloblastic-promyelocytic), and (b) with considerable numbers of positive cells (monoblastic-monocytic). In addition this test was also of value in the differentiation of other leukaemic disorders. Reduction of nitroblue-tetrazolium was also a feature of monocytic differentiation. The combination of these two methods with those for myeloperoxidase and non-specific esterase activity contributes to the cytological characterization of acute myeloid leukaemia.<\/jats:p>","DOI":"10.1136\/jcp.26.1.60","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T04:50:46Z","timestamp":1181364646000},"page":"60-69","source":"Crossref","is-referenced-by-count":24,"title":["Lysozyme activity and nitroblue-tetrazolium reduction in leukaemic cells"],"prefix":"10.1136","volume":"26","author":[{"given":"D.","family":"Catovsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A. G.","family":"Galton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,1,1]]},"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.26.1.60","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T10:59:25Z","timestamp":1717153165000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.26.1.60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1973,1,1]]},"published-print":{"date-parts":[[1973,1]]}},"alternative-id":["10.1136\/jcp.26.1.60"],"URL":"https:\/\/doi.org\/10.1136\/jcp.26.1.60","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,1]]}}}