{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:51:13Z","timestamp":1777355473361,"version":"3.51.4"},"reference-count":18,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1973,12]]},"abstract":"<jats:p>Numerous spironolactone bodies have been detected in the zona glomerulosa cells of the adrenal cortex of a 36-year-old spironolactone-treated woman whose non-tumorous right adrenal gland was removed surgically because of primary hyperaldosteronism. Electron microscopy revealed spherical laminated whorls which consisted of a central core composed of an amorphous electron-dense material surrounded by numerous smooth-walled concentric membranes. Continuous with and deriving from the endoplasmic reticulum, they were present in viable cells and were not associated with ultrastructural features indicating cellular injury. Cytoplasmic inclusions similar to spironolactone bodies can be detected in other organs after the administration of various compounds. Thus, they can be regarded as neither specific to spironolactone treatment nor exclusively inducible in the zona glomerulosa of the adrenal cortex.<\/jats:p>","DOI":"10.1136\/jcp.26.12.949","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"949-957","source":"Crossref","is-referenced-by-count":27,"title":["Fine structure and morphogenesis of spironolactone bodies in the zona glomerulosa of the human adrenal cortex"],"prefix":"10.1136","volume":"26","author":[{"given":"K.","family":"Kovacs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/ajcp\/54.1.22","article-title":"Spironolactone (Aldactone) bodies: concentric lamellar formations in the adrenal cortices of patients treated with spironolactone","volume":"54","author":"Davis, D.A.; Medline, N.M.","year":"1970","unstructured":"Davis, D. A., and Medline, N. M. (1970). Spironolactone (Aldactone) bodies: concentric lamellar formations in the adrenal cortices of patients treated with spironolactone. Amer. J. clin. Path., 54, 22-32.","journal-title":"Amer. J. clin. Path"},{"key":"ref_2","first-page":"471","article-title":"Experimental production of so-called spironolactone bodies","volume":"91","author":"Fisher, E.R.; Horvat, B.","year":"1971","unstructured":"Fisher, E. R., and Horvat, B. (1971). Experimental production of so-called spironolactone bodies. Arch. Path., 91, 471-478.","journal-title":"Arch. Path"},{"key":"ref_3","first-page":"61","article-title":"Ultrastructural changes in the rat liver following protracted treatment with pregnenolone-16z -carbonitrile and digitoxin","volume":"12","author":"Garg, B.D.; Kovacs, K.; Tuchweber, B.","year":"1972","unstructured":"Garg, B. D., Kovacs, K., and Tuchweber, B. (1972). Ultrastructural changes in the rat liver following protracted treatment with pregnenolone-16z -carbonitrile and digitoxin. Virchows Arch. Abt. B. Zellpath., 12, 61-72.","journal-title":"Virchows Arch. Abt. B. Zellpath"},{"key":"ref_4","first-page":"62","article-title":"Drug-induced and naturally occurring myeloid bodies","volume":"27","author":"Hruban, Z.; Slesers, A.; Hopkins, E.","year":"1972","unstructured":"Hruban, Z., Slesers, A., and Hopkins, E. (1972). Drug-induced and naturally occurring myeloid bodies. Lab. Invest., 27, 62-70.","journal-title":"Lab. Invest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/S0140-6736(63)91624-6","article-title":"Cytoplasmic bodies in the adrenal cortex of patients treated with spirolactone","volume":"1","author":"Janigan, D.T.","year":"1963","unstructured":"Janigan, D. T. (1963). Cytoplasmic bodies in the adrenal cortex of patients treated with spirolactone. 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Path., 62, 17-34.","journal-title":"Amer. J. Path"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/BF01946319","article-title":"Cycloheximide-induced ultrastructural changes in the corpus luteum of rats","volume":"29","author":"Kovacs, K.; Horvath, E.; Szabo, S.; Garg, B.D.; Tuchweber, B.","year":"1973","unstructured":"Kovacs, K., Horvath, E., Szabo, S., Garg, B. D., Tuchweber, B. (1973). Cycloheximide-induced ultrastructural changes in the corpus luteum of rats. Experientia (Basel), 29, 839-840.","journal-title":"Experientia (Basel)"},{"key":"ref_9","first-page":"211","article-title":"Formations lamellaires dans le cortex surrenalien du rat","volume":"82","author":"Kovacs, K.; Khandekar, J.D.; Szab6, S.; Garg, B.D.; Gardell, C.; Tuchweber, B.","year":"1971","unstructured":"Kovacs, K., Khandekar, J. D., Szab6, S., Garg, B. D., Gardell, C., and Tuchweber, B. (1971b). Formations lamellaires dans le cortex surrenalien du rat. Arch. Biol. (Liege), 82, 211-224.","journal-title":"Arch. Biol. (Liege)"},{"key":"ref_10","first-page":"105","article-title":"Effect of cycloheximide on the rat adrenal cortex. A light and electron microscopic study","volume":"31","author":"Kovacs, K.; Khandekar, J.D.; Szab6, S.; Garg, B.D.; Tuchweber, B.","year":"1972","unstructured":"Kovacs, K., Khandekar, J. D., Szab6, S., Garg, B. D., and Tuchweber, B. (1972). Effect of cycloheximide on the rat adrenal cortex. A light and electron microscopic study. Rev. canad. Biol., 31, 105-1 17.","journal-title":"Rev. canad. Biol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1001\/archinte.1958.00260230144018","article-title":"Aldosterone antagonists","volume":"102","author":"Liddle, G.W.","year":"1958","unstructured":"Liddle, G. W. (1958). Aldosterone antagonists. Arch. intern. Med., 102, 998-1004.","journal-title":"Arch. intern. Med"},{"key":"ref_12","first-page":"355","article-title":"Observations on the fine structure of the adrenal cortex of man","volume":"17","author":"Long, J.A.; Jones, A.L.","year":"1967","unstructured":"Long, J. A., and Jones, A. L. (1967). Observations on the fine structure of the adrenal cortex of man. Lab. Invest., 17, 355-370.","journal-title":"Lab. Invest"},{"key":"ref_13","article-title":"Fine structure of adrenal cortex","volume-title":"The Adrenal","author":"Luse, S.","year":"1967","unstructured":"Luse, S. (1967). Fine structure of adrenal cortex. In The Adrenal"},{"key":"ref_14","first-page":"116","article-title":"Lipoide Transformation der Mitochondrien in Nebennierenrindezellen nach Aminoglutathimid (Elipten Ciba)","volume":"6","author":"Marek, J.; Thoenes, W.; Motlik, K.","year":"1970","unstructured":"Marek, J., Thoenes, W., Motlik, K. (1970). Lipoide Transformation der Mitochondrien in Nebennierenrindezellen nach Aminoglutathimid (Elipten Ciba). Virchows. Arch. Abt. 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Acta. path. jap."},{"key":"ref_17","article-title":"Activation ofaldosterone secretion in primary hyperaldosteronism","author":"Spark, R.F.; Dale, S.L.; Kahn, P.C.; Melby, J.C.","year":"1969","unstructured":"Spark, R. F., Dale, S. L., Kahn, P. C., and Melby, J. C. (1969). Activation ofaldosterone secretion in primary hyperaldosteronism."},{"key":"ref_18","first-page":"169","article-title":"Electron microscopy of membrane-particle arrays in liver cells of ethionine intoxicated rats","volume":"44","author":"Steiner, J.W.; Miyai, K.; J, Phillips M.","year":"1964","unstructured":"Steiner, J. W, Miyai, K., and Phillips M. J. (1964). Electron microscopy of membrane-particle arrays in liver cells of ethionine intoxicated rats. Amer. J. Path., 44, 169-190.","journal-title":"Amer. J. 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