{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:09:10Z","timestamp":1765714150619,"version":"3.48.0"},"reference-count":3,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1973,4]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>Treponema pallidum<\/jats:italic>\n                    haemagglutination (TPHA) test was carried out on 274 sera known to show biological false positive reactions to reagin tests for syphilis. The\n                    <jats:italic>Treponema pallidum<\/jats:italic>\n                    immunization (TPI) and fluorescent treponemal antibody absorption (FTA-ABS) tests were non-reactive on all these sera. Thirty-one or 11\u00b73% showed reactive results in the TPHA test.\n                  <\/jats:p>\n                  <jats:p>Sera from 267 people who had lepromatous leprosy were also tested in the TPHA test. Fourteen sera were reactive in the TPHA, TPI, and FTA-ABS tests and were from people who had both syphilis and leprosy. Biological false positive reactions were shown by 26 of the leprosy sera, of which three or 11\u00b75% were also reactive in the TPHA test. A further four sera in the leprosy group were reactive only in the TPHA test.<\/jats:p>\n                  <jats:p>The possible cause of false reactive TPHA test results is discussed.<\/jats:p>\n                  <jats:p>It was concluded that where reagin and TPHA tests are reactive in a person who has no history or clinical signs of syphilis, the serum should be referred for TPI and FTA-ABS testing.<\/jats:p>","DOI":"10.1136\/jcp.26.4.258","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"258-260","source":"Crossref","is-referenced-by-count":19,"title":["The\n                    <i>Treponema pallidum<\/i>\n                    haemagglutination (TPHA) test in biological false positive and leprosy sera"],"prefix":"10.1136","volume":"26","author":[{"given":"M. F.","family":"Garner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Backhouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Daskalopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,4,1]]},"reference":[{"key":"ref_1","first-page":"48","article-title":"The treponema pallidum haemagglutination test for syphilis: a comparison with the TPI and FTA-ABS tests","author":"Garner, M.F.; Backhouse, J.L.; Daskalopoulos, G.; Walsh, J.L.","year":"1973","unstructured":"Garner, M. F., Backhouse, J. L., Daskalopoulos, G., and Walsh, J. L. (1973). The treponema pallidum haemagglutination test for syphilis: a comparison with the TPI and FTA-ABS tests. Brit. J. vener. Dis., 48,470-473.","journal-title":"Brit. J. vener. Dis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/jid.1967.15","article-title":"Group antibodies in fluorescent treponemal antibody (FTA) test","volume":"48","author":"Kiiily, K.; Jobbigy, A.; Kovats, L.","year":"1967","unstructured":"Kiiily, K., Jobbigy, A., and Kovats, L. (1967). Group antibodies in fluorescent treponemal antibody (FTA) test. J. invest. Derm., 48, 98-100.","journal-title":"J. invest. Derm"},{"key":"ref_3","article-title":"Automated qualitative and quantitative micro-haemagglutination assay for Treponema pallidum antibodies (AMHA-Tp). Provisional technique, modified","author":"Venereal Disease Research Laboratory, Atlanta","year":"1970","unstructured":"Venereal Disease Research Laboratory, Atlanta (1970). Automated qualitative and quantitative micro-haemagglutination assay for Treponema pallidum antibodies (AMHA-Tp). Provisional technique, modified October 20, 1970."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.26.4.258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:05:17Z","timestamp":1765713917000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.26.4.258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,4]]},"references-count":3,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1973,4,1]]},"published-print":{"date-parts":[[1973,4]]}},"alternative-id":["10.1136\/jcp.26.4.258"],"URL":"https:\/\/doi.org\/10.1136\/jcp.26.4.258","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1973,4]]}}}