{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:22:36Z","timestamp":1765081356864,"version":"3.46.0"},"reference-count":31,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1973,5]]},"abstract":"<jats:p>This memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunological status. The proposed protocols are intended to provide information that is not available in conventional written reports that use such terms as `hyperplasia' or `nonspecific lymphadenitis'.<\/jats:p>","DOI":"10.1136\/jcp.26.5.317","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"317-331","source":"Crossref","is-referenced-by-count":69,"title":["A proposal for a standardized system of reporting human lymph node morphology in relation to immunological function"],"prefix":"10.1136","volume":"26","author":[{"given":"H.","family":"Cottier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Turk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Sobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ar.1091550106","article-title":"Radioautographic studies of reticular and blast cells in the hemopoietic tissues of the rat","volume":"155","author":"Everett, N. B.; Rieke, W. 0","year":"1966","unstructured":"Everett, N. B., and Rieke,W. 0. (1966). Radioautographic studies of reticular and blast cells in the hemopoietic tissues of the rat. Anat. Rec., 155, 41.","journal-title":"Anat. Rec"},{"key":"ref_2","article-title":"Studieson lymphocytes","volume-title":"III.","author":"Cottier, H.; Cronkite, E.P.; Jansen, C.R.; Rai, K.; Sipe, C.R.","year":"1964","unstructured":"Cottier, H., Cronkite, E. P., Jansen, C. R., Rai, K., Sipe, C. R. (1964). Studieson lymphocytes.III."},{"key":"ref_3","article-title":"extracorporeal irradiation of the circulating blood upon lymphoreticular organs in the calf","volume":"24","author":"Cottier, H.; Hess, M.W.; Roos, B.; Gretillat, P.","year":"1969","unstructured":"extracorporeal irradiation of the circulating blood upon lymphoreticular organs in the calf. Blood, 24, Cottier, H., Hess, M. W., Roos, B., and Gretillat, P. (1969). Regeneration, Hyperplasie und Onkogenese der lymphoretikularen","journal-title":"Blood; Regeneration, Hyperplasie und Onkogenese der lymphoretikularen"},{"year":"1967","author":"Cottier, H.; Hess, M.; W.; Stoner, R.D.","key":"ref_4","unstructured":"Cottier, H., Hess, M,W., and Stoner, R. D. (1967)."},{"key":"ref_5","article-title":"Incorporation of tritiated nucleosides acids into lymphoid and plasmacytoid cells during","author":"D.","year":"1964","unstructured":"D. (1964). Incorporation of tritiated nucleosides acids into lymphoid and plasmacytoid cells during"},{"key":"ref_6","article-title":"Germinal Centers in Inmtnune Responses","author":"Cottier, H.","year":"1967","unstructured":"Cottier, H., Odartchenko, N., Schindler, R., and Congdon, C. C., Eds. (1967). Germinal Centers in Inmtnune Responses. Springer, Berlin, Heidelberg, and New York."},{"key":"ref_7","article-title":"The morphology of immune reactions in normal, thymectomized and reconstituted mice","author":"Davies, A.J.S.; Carter, R.L.; Leuchars, E.; Wallis, V.; Koller, P.C.","year":"1969","unstructured":"Davies, A. J. S., Carter, R. L., Leuchars, E., Wallis, V., and Koller, P. C. (1969). The morphology of immune reactions in normal, thymectomized and reconstituted mice."},{"key":"ref_8","article-title":"The response to sheep erythrocytes","volume":"16","unstructured":"The response to sheep erythrocytes. Imniunology, 16.","journal-title":"Imniunology"},{"year":"1969","author":"Davies, A.J.S.; Carter, R.L.; Leuchars, E.; Wallis, V.","key":"ref_9","unstructured":"Davies, A. J. S., Carter, R. L., Leuchars, E., and Wallis, V. (1969)."},{"issue":"1 1","key":"ref_10","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4684-3192-6","article-title":"The response to oxazolone","volume":"17","author":"1. Fiore-Donati, L.","year":"1969","unstructured":"The response to oxazolone. Inmmunology, 17, 1 1 1. Fiore-Donati, L., and Hanna, M. G., Jr., Eds. (1969). Lymphatic tissue and germinal centers in immune response. Adr,anc. exp.","journal-title":"Inmmunology; Lymphatic tissue and germinal centers in immune response. Adr, anc. exp"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/path.1711000103","article-title":"Granuloma formation in lymph nodes","volume":"100","author":"Gaafar, S.M.; Turk, J.L.","year":"1970","unstructured":"Gaafar, S. M., and Turk, J. L. (1970). Granuloma formation in lymph nodes. J. Path., 100, 9.","journal-title":"J. Path"},{"key":"ref_12","first-page":"41","article-title":"Essential relationship between the lymphoid system, immunity and mdlignancy","volume":"31","author":"Good, R.A.; Finstad, J.","year":"1969","unstructured":"Good, R. A., and Finstad, J. (1969). Essential relationship between the lymphoid system, immunity and mdlignancy. Nat. Cancer Inst. Monogr., 31, 41.","journal-title":"Nat. Cancer Inst. Monogr"},{"key":"ref_13","first-page":"257","article-title":"The route of recirculation of lymphocytes in the rat","volume":"159","author":"Gowans, J.L.; Knight, E.J.","year":"1964","unstructured":"Gowans, J. L., and Knight, E. J. (1964). The route of recirculation of lymphocytes in the rat. Proc. roY. Soc. B, 159, 257.","journal-title":"Proc. roY. Soc. B"},{"key":"ref_14","first-page":"1","article-title":"The immunological activities of lymphocytes","volume":"9","author":"Gowans, J.L.; McGregor, D.D.","year":"1965","unstructured":"Gowans, J. L., and McGregor, D. D. (1965). The immunological activities of lymphocytes. Progr. Allergy, 9, 1.","journal-title":"Progr. Allergy"},{"key":"ref_15","first-page":"367","article-title":"Kinetics of peripheral macrophages: facts and a working hypothesis","volume":"120","author":"Hess, M.W.; Roos, B.; Cottier, H.","year":"1971","unstructured":"Hess, M. W., Roos, B., and Cottier, H. (1971). Kinetics of peripheral macrophages: facts and a working hypothesis. Ann. Inst. Pasteur, 120, 367.","journal-title":"Ann. Inst. Pasteur"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1084\/jem.135.4.907","article-title":"Magnitude and pattern of thymic lymphocyte migration in neonatal mice","volume":"135","author":"Joel, D.D.; Hess, M.W.; Cottier, H.","year":"1972","unstructured":"Joel, D. D., Hess, M. W., and Cottier, H. (1972). Magnitude and pattern of thymic lymphocyte migration in neonatal mice. J. exp. Med., 135, 907.","journal-title":"J. exp. Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/003591577106400440","article-title":"Cell-mediated immunity and lymphocyte transformation in syphilis","volume":"64","author":"Levene, G.M.; Wright, D.J.M.; Turk, J.L.","year":"1971","unstructured":"Levene, G. M., Wright, D. J. M., and Turk, J. L. (1971). Cell-mediated immunity and lymphocyte transformation in syphilis. Proc. roy. Soc. Med., 64, 426.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_18","article-title":"Morphological and functional aspects of immunity","author":"Adtan","year":"1971","unstructured":"Lindahl-Kiessling, K., Alm,G., and Hanna, M. G., Jr., Eds. (1971). Morphological and functional aspects of immunity. Adtan."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0140-6736(61)90693-6","article-title":"Immunological function of the thymus","volume":"2","author":"Miller, J.F.A.P.","year":"1961","unstructured":"Miller, J. F. A. P. (1961). Immunological function of the thymus. Lancet, 2, 748.","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1084\/jem.128.4.801","article-title":"Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes","volume":"128","author":"Miller, J.F.A.P.; Mitchell, G.F.","year":"1968","unstructured":"Miller, J. F. A. P., and Mitchell,G. F. (1968). Cell to cell interaction in the immune response.I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes. J. exp. Med., 128, 801.","journal-title":"J. exp. Med"},{"key":"ref_21","article-title":"Migration intratissulaire des lymphocytes dLI","author":"Morris, B.","year":"1968","unstructured":"Morris, B. (1968). Migration intratissulaire des lymphocytes dLI"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1084\/jem.123.1.191","article-title":"Thymusdependent areas in the lymphoid organs of neonatally thymectomized mice","volume":"123","author":"Parrott, D.M.V.; de Sousa, M.A.B.; East, J.","year":"1966","unstructured":"Parrott, D. M. V., de Sousa, M. A. B., and East, J. (1966). Thymusdependent areas in the lymphoid organs of neonatally thymectomized mice. J. exp. Med., 123, 191.","journal-title":"J. exp. Med"},{"key":"ref_23","first-page":"663","article-title":"Thymus-dependent and thymus-independent populations: origin, migratory patterns and life span","volume":"8","author":"Parrott, D.M.V.; de Sousa, M.A.B.","year":"1971","unstructured":"Parrott, D. M. V., and de Sousa, M. A. B. (1971). Thymus-dependent and thymus-independent populations: origin, migratory patterns and life span. Clin. exp. Immunol., 8, 663.","journal-title":"Clin. exp. Immunol"},{"key":"ref_24","article-title":"Studies on lymphocytes. XVII. Differential lymphocyte depletion in lymphoreticular organs of the calf during continuous extracorporealx-irradiation of the circulating blood","author":"Ruchti, C.; Cottier, H.; Cronkite, E.P.; Jansen, C.R.; Rai, K.R.","year":"1970","unstructured":"Ruchti, C., Cottier, H., Cronkite, E. P., Jansen, C. R., and Rai, K. R. (1970). Studies on lymphocytes. XVII. Differential lymphocyte depletion in lymphoreticular organs of the calf during continuous extracorporealx-irradiation of the circulating blood."},{"key":"ref_25","article-title":"Specific antibody within lymphoid germinal center cells of mice after primary immunization with horseradish peroxidase: a light and electron microscopic study","volume":"131","author":"Sordat, B.; Sordat, M.; Hess, M.W.; Stoner, R.D.; Cottier, H.","year":"1970","unstructured":"Sordat, B., Sordat, M., Hess, M. W., Stoner, R. D., and Cottier, H. (1970). Specific antibody within lymphoid germinal center cells of mice after primary immunization with horseradish peroxidase: a light and electron microscopic study. J. exp. Med., 131.","journal-title":"J. exp. Med"},{"key":"ref_26","first-page":"115","article-title":"gG immunoglobulin in the wall of post-capillary venules: possible relationship to lymphocyte recirculation","volume":"20","author":"Sordat, B.; Hess, M.W.; Cottier, H.","year":"1971","unstructured":"Sordat, B., Hess, M. W., and Cottier, H. (1971)I. gG immunoglobulin in the wall of post-capillary venules: possible relationship to lymphocyte recirculation. Immnunology, 20, 115. Turk, J. L., and Bryceson, A. D. M. (1971). Immunological phenomena in leprosy and related diseases. Advranc. Intmunol., 13.","journal-title":"Immnunology; Immunological phenomena in leprosy and related diseases"},{"key":"ref_27","article-title":"Immunological significance of changes in lymph nodes across the leprosy spectrum. Clit?","author":"Turk, J.L.; Waters, M.F.R.","year":"1971","unstructured":"Turk, J. L., and Waters, M. F. R. (1971). Immunological significance of changes in lymph nodes across the leprosy spectrum.Clit?."},{"key":"ref_28","first-page":"392","article-title":"The production of sensitized cells in cell-mediated immunity. In Handbuch der allgemeinen Pathsologie","volume":"\"Vol.\" # \"pt. 3,\"","author":"Turk, J.L.; Oort, J.","year":"1970","unstructured":"Turk, J. L., and Oort, J. (1970). The production of sensitized cells in cell-mediated immunity. In Handbuch der allgemeinen Pathsologie (edited by H. Cottier and A. Studer, Vol. 7,pt. 3, p. 392."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1177\/003591577106400929","article-title":"Granularma formation in lymph nodes","volume":"64","author":"Turk, J.L.","year":"1971","unstructured":"Turk, J. L. (1971). Granularma formation in lymph nodes. Proc. roY. Soc. Med., 64, 942.","journal-title":"Proc. roY. Soc. Med"},{"key":"ref_30","first-page":"446","article-title":"Studieos n the ontogeny of the mouse immune system","volume":"101","author":"Tyan, M.L.; Herzenberg, L.A.","year":"1968","unstructured":"Tyan, M. L., and Herzenberg, L. A. (1968). Studieos n the ontogeny of the mouse immune system. J. Imnntunol., 101, 446.","journal-title":"J. Imnntunol"},{"key":"ref_31","first-page":"187","article-title":"Role of the thymus in immune reactions in rats. III. Changes in the lymphoid organs of thymectomirats","volume":"116","author":"Waksman, B.H.; Arnason, B.G.; Jankovic, B.D.","year":"1962","unstructured":"Waksman, B. H., Arnason, B. G., and Jankovic, B. D. (1962). Role of the thymus in immune reactions in rats. III. Changes in the lymphoid organs of thymectomi7ed rats. J.exp. Med., 116. 187.","edition":"7","journal-title":"J.exp. Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.26.5.317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:43:15Z","timestamp":1765075395000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.26.5.317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,5]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1973,5,1]]},"published-print":{"date-parts":[[1973,5]]}},"alternative-id":["10.1136\/jcp.26.5.317"],"URL":"https:\/\/doi.org\/10.1136\/jcp.26.5.317","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1973,5]]}}}