{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:59:01Z","timestamp":1779893941044,"version":"3.53.1"},"reference-count":13,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1973,8]]},"abstract":"<jats:p>\n                    Fat embolism is a known complication of marrow infarction in patients with sickle cell disease (Hb S\/S and Hb S\/C) disease. It should be considered in sickle cell crisis when there is deterioration in respiratory function, a fall in arterial PO\n                    <jats:sub>2<\/jats:sub>\n                    , a normoblastaemia, and a thrombocytopenia in the peripheral blood. We now report a patient in whom the diagnosis was confirmed in life by identifying fat in the sputum, demonstrating disseminated intravascular coagulation, and using a double isotope technique to distinguish recent from old marrow infarction. Use of these features enabled an early diagnosis to be made which led to a successful outcome in a potentially fatal condition.\n                  <\/jats:p>","DOI":"10.1136\/jcp.26.8.620","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"620-622","source":"Crossref","is-referenced-by-count":37,"title":["Fat embolism in sickle cell disease"],"prefix":"10.1136","volume":"26","author":[{"given":"R. M.","family":"Hutchinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Merrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1973,8,1]]},"reference":[{"key":"ref_1","first-page":"408","article-title":"Scan detection of bone marrow infarcts in sickle cell anemia","volume":"13","author":"Alavi, A.; Bond, J.P.; Kuhl, D.E.; Creech, R.H.","year":"1972","unstructured":"Alavi, A., Bond, J. P., Kuhl, D. E., and Creech, R. H. (1972). Scan detection of bone marrow infarcts in sickle cell anemia. J. nucl. Med., 13, 408.","journal-title":"J. nucl. Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00005373-197004000-00004","article-title":"Coagulation alterations, hypoxemia and fat embolism in fracture patients","volume":"10","author":"Bradford, D.S.; Foster, R.P.; Nossel, H.L.","year":"1970","unstructured":"Bradford, D. S., Foster, R. P., and Nossel, H. L. (1970). Coagulation alterations, hypoxemia and fat embolism in fracture patients. J. Trauma, 10, 307-321.","journal-title":"J. Trauma"},{"key":"ref_3","first-page":"189","article-title":"Bone marrow necrosis: a study of seventy cases","volume":"131","author":"Brown, C.H.","year":"1972","unstructured":"Brown, C. H. (1972). Bone marrow necrosis: a study of seventy cases. Johns Hopk. med. J., 131, 189-203.","journal-title":"Johns Hopk. med. J"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.7326\/0003-4819-67-6-1195","article-title":"Infarction of bone marrow in the sickle cell disorders","volume":"67","author":"Charache, S.; Page, D.L.","year":"1967","unstructured":"Charache, S., and Page, D. L. (1967). Infarction of bone marrow in the sickle cell disorders. Ann intern. Med., 67, 1195-1200.","journal-title":"Ann intern. Med"},{"key":"ref_5","first-page":"425","article-title":"Assessment of bone and marrow in sickle cell disease","volume":"13","author":"Denardo, S.J.; Hammel, C.F.; Lewis, J.P.; Denardo, G.L.","year":"1972","unstructured":"Denardo, S. J., Hammel, C. F., Lewis, J. P., and Denardo, G. L. (1972). Assessment of bone and marrow in sickle cell disease. J. nucl. Med., 13, 425-426.","journal-title":"J. nucl. Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0002-9378(66)90406-6","article-title":"The influence of hemoglobinopathies on reproduction","volume":"94","author":"Hendrickse, J.P.D.; Watson-Williams, E.J.","year":"1966","unstructured":"Hendrickse, J. P. D., and Watson-Williams, E. J. (1966). The influence of hemoglobinopathies on reproduction. Amer. J. Obstet. Gynec., 94, 739-748.","journal-title":"Amer. J. Obstet. Gynec"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0001-2998(72)80008-4","article-title":"Marrow studies with radiocolloids","volume":"2","author":"Kniseley, R.M.","year":"1972","unstructured":"Kniseley, R. M. (1972). Marrow studies with radiocolloids. Sem. nuel. Med., 2, 71-85.","journal-title":"Sem. nuel. Med"},{"key":"ref_8","article-title":"The current status of bone scanning. La Ricerca in Clinice e Laboratoria","author":"Merrick, M.V.","year":"1973","unstructured":"Merrick, M. V. (1973). The current status of bone scanning. La Ricerca in Clinice e Laboratoria, 2, in press."},{"key":"ref_9","first-page":"658","article-title":"Hemoglobin S. C. Disease with fat embolism","volume":"27","author":"Ober, W.B.; Brunc, M.S.; Simon, R.M.; Weiner, L.","year":"1959","unstructured":"Ober, W. B., Brunc, M. S., Simon, R. M., and Weiner, L. (1959). Hemoglobin S.C. Disease with fat embolism. Amer. J. Med., 27, 658-674.","journal-title":"Amer. J. Med"},{"key":"ref_10","first-page":"10551059","volume":"86","author":"Rywlin, A.M.; Block, A.L.; Werner, C.S.","year":"1963","unstructured":"Rywlin, A. M., Block, A. L., and Werner, C. S. (1963). Hemoglobin C and S disease in pregnancy. Amer. J. Obstet. Gynec., 86, 10551059.","journal-title":"Hemoglobin C and S disease in pregnancy. Amer. J. Obstet. Gynec"},{"key":"ref_11","first-page":"8","article-title":"Bone marrow and fat embolism in sickle cell anemia and sickle cell-haemoglobin C disease","volume":"103","author":"Shelley, W.M.; Curtis, E.M.","year":"1958","unstructured":"Shelley, W. M., and Curtis, E. M. (1958). Bone marrow and fat embolism in sickle cell anemia and sickle cell-haemoglobin C disease. Johns Hopk. med. J., 103, 8-18.","journal-title":"Johns Hopk. med. J"},{"key":"ref_12","first-page":"665","article-title":"Preparation, distribution and utilization of technetium-99m-sulphur colloid","volume":"7","author":"Stern, H.S.; McAfee, J.G.; Subramanian, G.","year":"1966","unstructured":"Stern, H. S., McAfee, J. G., and Subramanian, G. (1966). Preparation, distribution and utilization of technetium-99m-sulphur colloid. J. nucl. Med., 7, 665-675.","journal-title":"J. nucl. Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/archneurpsyc.1942.02290050054004","article-title":"The brain in sickle cell anemia","volume":"47","author":"Wertha-n, F.; Mitchell, N.; Angrist, A.","year":"1942","unstructured":"Wertha-n, F., Mitchell, N., and Angrist, A. (1942). The brain in sickle cell anemia. Arch. Neurol., 47, 752-767.","journal-title":"Arch. 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