{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:54:27Z","timestamp":1765713267961,"version":"3.48.0"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,1]]},"abstract":"\n Sera from 200 pregnant women, with symptoms suggestive of vaginitis and harbouring yeast in the vagina, were examined for precipitating antibodies to three antigens of\n C. albicans<\/jats:italic>\n , using a gel double diffusion test. A high overall incidence of precipitin-positive sera (47.5%) was found compared with an incidence of 18% in the unselected pregnant population previously studied (Stanley, Hurley, and Carroll 1972).\n <\/jats:p>\n \n Using the clinicopathological criteria of Carroll, Hurley, and Stanley (1973), a final aetiological diagnosis of\n C. albicans<\/jats:italic>\n mycosis was reached in 75 cases and precipitins were demonstrated in 64%. Forty-eight women harbouring\n C. albicans<\/jats:italic>\n responded favourably to a single course of antifungal treatment, and probably had mycotic vaginitis. The incidence of precipitins in this group was 42%.\n C. albicans<\/jats:italic>\n was isolated from a further 55 of 62 patients, in whom the incidence of precipitins was 32%.\n <\/jats:p>\n `Booking' sera were investigated from 50 of the 200 women studied. Sixty-four per cent of women had symptoms of vaginitis at booking and 32% were precipitin positive. Twenty-eight per cent had precipitins on both occasions, and a further 24% acquired candida precipitins during pregnancy.<\/jats:p>\n \n None of the seven newborn with oral or skin thrush had precipitins to\n C. albicans.<\/jats:italic>\n <\/jats:p>\n \n The results indicate that the detection of precipitating antibodies to\n C. albicans<\/jats:italic>\n , particularly to all three of the antigens described in this paper, would be a useful additional criterion in the diagnosis of candida vaginitis, particularly if the vaginitis were persistent, recurrent, or unresponsive to therapy. The sensitivity of the test system used was 64%, and its specificity 87%; as such, the test is valid and may be reasonably useful as a screening procedure.\n <\/jats:p>","DOI":"10.1136\/jcp.27.1.66","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"66-69","source":"Crossref","is-referenced-by-count":11,"title":["Candida precipitins in pregnant women: validity of the test systems used"],"prefix":"10.1136","volume":"27","author":[{"given":"Valerie C.","family":"Stanley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalinde","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1471-0528.1973.tb02195.x","article-title":"Criteria for diagnosis of candida vulvovaginitis in pregnant women","volume":"80","author":"Carroll, C.J.; Hurley, R.; Stanley, V.C.","year":"1973","unstructured":"Carroll, C. J., Hurley, R., and Stanley, V. C. (1973). Criteria for diagnosis of candida vulvovaginitis in pregnant women. J. Obstet. Gynaec. Brit. Cwlth, 80, 258-263.","journal-title":"J. Obstet. Gynaec. Brit. Cwlth"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/jama.1933.02740030025008","article-title":"Diabetic or mycotic vulvovaginitis","volume":"100","author":"Hesseltine, H.C.","year":"1933","unstructured":"Hesseltine, H. C. (1933). Diabetic or mycotic vulvovaginitis. J. Amer. med. Ass., 100, 177-178.","journal-title":"J. Amer. med. Ass"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1471-0528.1973.tb02194.x","article-title":"Incidence and distribution of yeast species and Trichomonas vaginalis in the vagina of pregnant women","volume":"80","author":"Hurley, R.; Leask, B.G.S.; Faktor, J.A.; de Fonseka, C.I.","year":"1973","unstructured":"Hurley, R., Leask, B. G. S., Faktor, J. A., and de Fonseka, C. I. (1973). Incidence and distribution of yeast species and Trichomonas vaginalis in the vagina of pregnant women. J. Obstet. Gynaec. Brit. Cwlth, 80, 252-257.","journal-title":"J. Obstet. Gynaec. Brit. Cwlth"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1099\/00222615-5-1-21","article-title":"Evaluationofsporulation media for yeasts obtained from pathological material","volume":"5","author":"Merritt, A.E.; Hurley, R.","year":"1972","unstructured":"Merritt, A. E., and Hurley, R. (1972). Evaluationofsporulation media for yeasts obtained from pathological material. J. Med. Microbiol., 5, 21-30.","journal-title":"J. Med. Microbiol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1099\/00222615-2-4-463","article-title":"Serological evidence of candida infection after open-heart surgery","volume":"2","author":"Murray, I.G.; Buckley, H.R.; Turner, G.C.","year":"1969","unstructured":"Murray, I. G., Buckley, H. R., and Turner, G. C. (1969). Serological evidence of candida infection after open-heart surgery. J. med. Microbiol., 2, 463-469.","journal-title":"J. med. Microbiol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0021-8707(68)90073-7","article-title":"Candida albicans precipitins in respiratory disease in man","volume":"41","author":"Pepys, J.; Faux, J.A.; Longbottom, J.L.; McCarthy, D.S.; Hargreave, F.E.","year":"1968","unstructured":"Pepys, J., Faux, J. A., Longbottom, J. L., McCarthy, D. S., and Hargreave, F. E. (1968). Candida albicans precipitins in respiratory disease in man. J. Allergy, 41, 305-318.","journal-title":"J. Allergy"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1099\/00222615-5-3-313","article-title":"Distribution and significance of candida precipitins in sera from pregnant women","volume":"5","author":"Stanley, V.C.; Hurley, R.; Carroll, C.J.","year":"1972","unstructured":"Stanley, V. C., Hurley, R., and Carroll, C. J. (1972). Distribution and significance of candida precipitins in sera from pregnant women. J. med. Microbiol., 5, 313-320.","journal-title":"J. med. Microbiol"},{"key":"ref_8","first-page":"22","article-title":"Principles and Practice of Screeningfor Disease, (WHO","volume":"34","author":"Wilson, J.M.G.; Jungner, G.","year":"1968","unstructured":"Wilson, J. M. G., and Jungner, G. (1968). Principles and Practice of Screeningfor Disease, (WHO Public Health Papers, no. 34) p. 22. World Health Organization, Geneva.","journal-title":"Public Health Papers; World Health Organization, Geneva."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.27.1.66","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:50:49Z","timestamp":1765713049000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.27.1.66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1974,1,1]]},"published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1136\/jcp.27.1.66"],"URL":"https:\/\/doi.org\/10.1136\/jcp.27.1.66","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}