{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:03:02Z","timestamp":1765598582160,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,10]]},"abstract":"<jats:p>\n                    Clinical and histological features provide evidence that immunological reactions of the cell-mediated type are abnormal in some forms of chronic liver disease. By using the leucocyte migration test of S\u00f8borg and Bendixen (1967), a correlate of cellular hypersensitivity\n                    <jats:italic>in vitro<\/jats:italic>\n                    , the authors studied the production of the migration inhibitory factor by lymphocytes exposed to a fetal liver homogenate in 88 patients with acute and chronic liver disease. Abnormality of leucocyte migration was found in aggressive chronic hepatitis (inhibition in 67% of patients), cryptogenic cirrhosis (inhibition in 43%, stimulation in 13% of patients), and primary biliary cirrhosis (stimulation in two, inhibition in two out of six patients).\n                  <\/jats:p>\n                  <jats:p>The results are compatible with the hypothesis that cellular immune response to liver antigens is important in the pathogenesis of such diseases.<\/jats:p>","DOI":"10.1136\/jcp.27.10.772","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"772-775","source":"Crossref","is-referenced-by-count":5,"title":["Leucocyte migration inhibition in liver disease"],"prefix":"10.1136","volume":"27","author":[{"given":"C.","family":"Vergani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Oldoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Dioguardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1177\/003591577006300919","article-title":"Migration inhibition studies in human disease","volume":"63","author":"Brostoff, J.","year":"1970","unstructured":"Brostoff, J. (1970). Migration inhibition studies in human disease. Proc. roy. Soc. Med., 63, 905-906.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_2","first-page":"1323","article-title":"Distinctions in chronic active hepatitis based on circulating hepatitis-associated antigen","volume":"2","author":"Bulkley, B.H.; Heizer, W.D.; Goldfinger, S.E.; Isselbacher, K.J.","year":"1970","unstructured":"Bulkley, B. H., Heizer, W. D., Goldfinger, S. E., and Isselbacher, K. J. (1970). Distinctions in chronic active hepatitis based on circulating hepatitis-associated antigen. Lancet, 2, 1323-1326.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/oxfordjournals.qjmed.a067264","article-title":"Controlled prospective trial of corticosteroid therapy in active chronic hepatitis","volume":"40","author":"Cook, G.C.; Mulligan, R.; Sherlock, S.","year":"1971","unstructured":"Cook, G. C., Mulligan, R., and Sherlock, S. (1971). Controlled prospective trial of corticosteroid therapy in active chronic hepatitis. Quart. J. Med., 40, 159-185.","journal-title":"Quart. J. Med"},{"key":"ref_4","first-page":"119","article-title":"Effect of prednisone on the survival of patients with cirrhosis of the liver","volume":"1","author":"Copenhagen Study Group for Liver Diseases","year":"1969","unstructured":"Copenhagen Study Group for Liver Diseases (1969). Effect of prednisone on the survival of patients with cirrhosis of the liver. Lancet, 1, 119-121.","journal-title":"Lancet"},{"issue":"398 407","key":"ref_5","article-title":"Cellular hypersensitivity and immunity","volume":"16","author":"David, J.R.; David, R.R.","year":"1972","unstructured":"David, J. R., and David, R. R. (1972). Cellular hypersensitivity and immunity. Progr. Allergy, 16, 398 407.","journal-title":"Progr. Allergy"},{"key":"ref_6","first-page":"626","article-title":"A classification of chronic hepatitis","volume":"2","author":"De Groote, J.; Gedigk, P.; Popper, H.; Scheuer, P.J.; Thaler, H.; Wepler, W.; Desmet, U.J.; Korb, G.; Poulsen, H.; Schmid, M.; Vehlinger, E.","year":"1968","unstructured":"De Groote, J., Gedigk, P., Popper, H., Scheuer, P. J., Thaler, H., Wepler, W., Desmet, U. J., Korb, G., Poulsen, H., Schmid, M., and Vehlinger, E. (1968). A classification of chronic hepatitis. Lancet, 2, 626-628.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/003591577006300548","article-title":"The concept of an 'autoallergic' hepatitis","volume":"63","author":"Doniach, D.","year":"1970","unstructured":"Doniach, D. (1970). The concept of an 'autoallergic' hepatitis. Proc. roy. Soc. Med., 63, 527-531.","journal-title":"Proc. roy. Soc. 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Lancet, 2, 1388-1393.","journal-title":"Lancet"},{"key":"ref_10","first-page":"296","article-title":"Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis","volume":"2","author":"Miller, J.; Smith, M.G.M.; Mitchell, C.G.; Reed, W.D.; Eddleston, A.L.W.F.; Williams, R.","year":"1972","unstructured":"Miller, J., Smith, M. G. M., Mitchell, C. G., Reed, W. D., Eddleston, A. L. W. F., and Williams, R. (1972). Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet, 2, 296-297.","journal-title":"Lancet"},{"key":"ref_11","first-page":"305","article-title":"The treatment of active chronic hepatitis with 6-mercaptopurine and azathioprine","volume":"16","author":"Mistilis, S.P.; Blackburn, C.R.B.","year":"1967","unstructured":"Mistilis, S. P., and Blackburn, C. R. B. (1967). The treatment of active chronic hepatitis with 6-mercaptopurine and azathioprine. Aust. Ann. Med., 16, 305-311.","journal-title":"Aust. Ann. Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0002-9343(70)90049-5","article-title":"Active chronic'","volume":"48","author":"Mistilis, S.P.; Blackburn, C.R.B.","year":"1970","unstructured":"Mistilis, S. P., and Blackburn, C. R. B. (1970). Active chronic' hepatitis. Amer. J. Med., 48, 484-495.","journal-title":"hepatitis. Amer. J. Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(73)92125-9","article-title":"Controlled trial of prednisone and azathioprine in active chronic hepatitis","volume":"1","author":"Murray-Lyon, I.M.; Stern, R.B.; Williams, R.","year":"1973","unstructured":"Murray-Lyon, I. M., Stern, R. B., and Williams, R. (1973). Controlled trial of prednisone and azathioprine in active chronic hepatitis. Lancet, 1, 735-737.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/B978-0-433-30725-9.50009-4","article-title":"Morphological and immunological studies on chronic aggressive hepatitis and primary biliary cirrhosis","volume-title":"Immunology of the Liver","author":"Popper, H.","year":"1971","unstructured":"Popper, H. (1971). Morphological and immunological studies on chronic aggressive hepatitis and primary biliary cirrhosis. In Immunology of the Liver, edited by M. Smith and R. Williams, pp. 17-27. Heinemann, London."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/bmj.1.5799.527","article-title":"Cell mediated responses in chronic liver diseases","volume":"1","author":"Smith, M.G.M.; Golding, P.L.; Eddleston, A.L.W.F.; Mfitchell, C.G.; Kemp, A.; Williams, R.","year":"1972","unstructured":"Smith, M. G. M., Golding, P. L., Eddleston, A. L. W. F., Mfitchell, C. G., Kemp, A., and Williams, R. 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Gastroenterology, 63, 820-833.","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0140-6736(67)91830-2","article-title":"Lymphocyte stimulation and chronic liver disease","volume":"1","author":"Tobias, H.; Safran, A.P.; Schaffner, F.","year":"1967","unstructured":"Tobias, H., Safran, A. P., and Schaffner, F. (1967). Lymphocyte stimulation and chronic liver disease. Lancet, 1, 193-195.","journal-title":"Lancet"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.27.10.772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:00:02Z","timestamp":1765598402000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.27.10.772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,10]]},"references-count":19,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1974,10,1]]},"published-print":{"date-parts":[[1974,10]]}},"alternative-id":["10.1136\/jcp.27.10.772"],"URL":"https:\/\/doi.org\/10.1136\/jcp.27.10.772","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1974,10]]}}}