{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:19:49Z","timestamp":1764998389600,"version":"3.46.0"},"reference-count":37,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,10]]},"abstract":"<jats:p>A case of systemic nodular panniculitis is described in which the myocardium was found at necropsy to be extensively involved with focal interstitial carditis, identical histologically with nodules of panniculitis biopsied from the skin. This degree of myocardial involvement, which was not apparent during life and was not confined to pericardial or myocardial adipose tissue, has not previously been reported. The literature relating to nodular panniculitis is briefly reviewed and the concept of Weber-Christian disease critically re-appraised.<\/jats:p>","DOI":"10.1136\/jcp.27.10.808","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"808-812","source":"Crossref","is-referenced-by-count":11,"title":["Systemic nodular panniculitis with cardiac involvement"],"prefix":"10.1136","volume":"27","author":[{"given":"P. J.","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R. M.","family":"Harman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Tribe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,10,1]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Factitial Weber-Christian syndrome","volume":"73","author":"Ackerman, A.B.; Mosher, D.T.; Schwamm, H.A.","year":"1966","unstructured":"Ackerman, A. B., Mosher, D. T., and Schwamm, H. A. (1966). Factitial Weber-Christian syndrome. J. Amer. med. Ass., 198, 73 1-736.","journal-title":"J. Amer. med. Ass"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/00000441-195304000-00012","article-title":"Weber-Christian syndrome","volume":"225","author":"Beerman, H.","year":"1953","unstructured":"Beerman, H. (1953). Weber-Christian syndrome. Amer. J. mned. Sci., 225, 446-462.","journal-title":"Amer. J. mned. Sci"},{"key":"ref_3","first-page":"694","article-title":"Relapsing febrile, nodular, non-suppurative panniculitis. (Weber-Christian disease)","volume-title":"Medical Papers Dedicated to","author":"Brill, 1. C","year":"1936","unstructured":"Brill, 1. C. (1936). Relapsing febrile, nodular, non-suppurative panniculitis. (Weber-Christian disease). In Medical Papers Dedicated to H. A. Christian, pp. 694-704, Waverly Press, Baltimore."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJM195010052431401","article-title":"Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease): relation to rheumatic fever and allied diseases","volume":"243","author":"Brudno, J.C.","year":"1950","unstructured":"Brudno, J. C. (1950). Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease): relation to rheumatic fever and allied diseases. New Engl. J. Med., 243, 513-517.","journal-title":"New Engl. J. Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archderm.1966.01600260053006","article-title":"Unusual acid-fast bacteria in panniculitis","volume":"94","year":"1966","unstructured":"Cantwell, A. R. Jr., Craggs, E., Swatek, F., and Wilson, J. W. (1966). Unusual acid-fast bacteria in panniculitis. Arch. Derm., 94, 161-167.","journal-title":"Arch. Derm"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/archinte.1928.00020020026004","article-title":"Relapsing febrile nodular nonsuppurative panniculitis","volume":"42","author":"Christian, H.A.","year":"1928","unstructured":"Christian, H. A. (1928). Relapsing febrile nodular nonsuppurative panniculitis. Arch. intern. Med., 42, 338-351.","journal-title":"Arch. intern. Med"},{"issue":"169179","key":"ref_7","article-title":"Isolated lipodystrophy: a form of mesenteric tumor","volume":"90","year":"1955","unstructured":"Crane, J. T., Aguilar, M. J., and Grimes, 0. F. (1955). 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A unique case of atrophy of the fatty layer of the skin, preceded by the ingestion of the fat by large phagocytic cells-macrophages. Johns Hopk. Hosp. Bull., 27, 291-294.","journal-title":"Johns Hopk. Hosp. Bull"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1365-2133.1967.tb11491.x","article-title":"Weber-Christian syndrome of pancreatic origin","volume":"79","author":"de Graciansky, P.","year":"1967","unstructured":"de Graciansky, P. (1967). Weber-Christian syndrome of pancreatic origin. Brit. J. Derm., 79, 278-283.","journal-title":"Brit. J. Derm"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/jama.1963.03700050050011","article-title":"Mesenteric panniculitis","volume":"183","author":"Grossman, L.A.; Kaplan, H.J.; Preuss, H.J.; Herrington, Jr, J.L.","year":"1963","unstructured":"Grossman, L. A., Kaplan, H. J., Preuss, H. J., and Herrington, J. L., Jr. (1963). Mesenteric panniculitis. J. Amer. med. 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Inflammatory diseases of the subcutaneous fat."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1001\/jama.1967.03120060126031","article-title":"Panniculitis, vasculitis and a positive lupus erythematosus cell test","author":"Macoul, K.L.","year":"1967","unstructured":"Macoul, K. L. (1967). Panniculitis, vasculitis and a positive lupus erythematosus cell test. J. Amer. med. Ass., 199, 428-430.","journal-title":"J. Amer. med. Ass"},{"key":"ref_20","first-page":"\"150","article-title":"Systemic Weber-Christian disease","volume":"18","author":"Milner, R.D.G.; Mitchinson, M.J.","year":"1965","unstructured":"Milner, R. D. G., and Mitchinson, M. J. (1965). Systemic Weber-Christian disease. J. clin. Path., 18, 150-156. 0stergaard, P. A. (1970). Weber-Christian disease. Toxoplasmosis as a possible aetiological factor in panniculitis of the Weber-Christian type. Dan. med. Bull., 17, 158-160.","journal-title":"J. clin. Path; Weber-Christian disease. 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Syndrome associated with pancreatic acinar cell carcinoma. Brit. med. J., 2, 708-709.","journal-title":"Brit. med. J"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1001\/jama.1968.03140100072023","article-title":"Weber-Christian disease: report of a case documenting the presence of leukoagglutinins","volume":"203","author":"Rosenstock, H.A.","year":"1968","unstructured":"Rosenstock, H. A. (1968). Weber-Christian disease: report of a case documenting the presence of leukoagglutinins. J. Amer. med. Ass., 203, 890-891.","journal-title":"J. Amer. med. Ass"},{"key":"ref_27","first-page":"156","article-title":"Chronic panniculitis with leucopenia (Weber-Christian syndrome)","volume":"83","author":"Sanford, H.N.; Eubank, D.F.; Stenn, F.","year":"1952","unstructured":"Sanford, H. N., Eubank, D. F., and Stenn, F. (1952). Chronic panniculitis with leucopenia (Weber-Christian syndrome). Amer. J. Dis. Child, 83, 156-163.","journal-title":"Amer. J. Dis. Child"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1177\/003591576906201235","article-title":"Recurrent non-scarring pressure panniculitis","volume":"62","author":"Sarkany, I.; Macmillan, A.L.","year":"1970","unstructured":"Sarkany, I., and Macmillan, A. L. (1970). Recurrent non-scarring pressure panniculitis. Proc. roy. Soc. Med., 62, 1279-1280.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_29","first-page":"1219","article-title":"Bowel obstruction, unusual manifestation of Weber-Christian disease","volume":"55","author":"Sattler, M.E.; Greenberg, A.I.","year":"1956","unstructured":"Sattler, M. E., and Greenberg, A. I. (1956). Bowel obstruction, unusual manifestation of Weber-Christian disease. Wisc. med. J., 55, 1219-1222.","journal-title":"Wisc. med. J"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0016-5085(19)34369-0","article-title":"Fatal mesenteric panniculitis","volume":"51","author":"Soergel, K.H.; Hensley, G.T.","year":"1966","unstructured":"Soergel, K. H., and Hensley, G. T. (1966). Fatal mesenteric panniculitis. Gastroenterology, 51, 529-536.","journal-title":"Gastroenterology"},{"key":"ref_31","article-title":"Post-steroid panniculitis","author":"Spagnuolo, M.; Taranta, A.","year":"1961","unstructured":"Spagnuolo, M., and Taranta, A. (1961). Post-steroid panniculitis."},{"key":"ref_32","first-page":"1059","article-title":"Systemic nodular panniculitis","volume":"29","author":"Steinberg, B.","year":"1953","unstructured":"Steinberg, B. (1953). Systemic nodular panniculitis. Amer. J. Path., 29, 1059-1081.","journal-title":"Amer. J. Path"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1017\/S0022215100039359","article-title":"Progressive lethal granulomatous ulceration of the nose","volume":"48","author":"Stewart, J.P.","year":"1933","unstructured":"Stewart, J. P. (1933). Progressive lethal granulomatous ulceration of the nose. J. Laryng., 48, 657-701.","journal-title":"J. Laryng"},{"key":"ref_34","article-title":"Retractile mesenteritis","author":"Tedeschi, C.G.; Botta, G.C.","year":"1962","unstructured":"Tedeschi, C. G., and Botta, G. C. (1962). Retractile mesenteritis. New"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1001\/archderm.1971.04000150001001","article-title":"Lupus erythematosus panniculitis (Profundus): clinical and immunologic studies","volume":"103","author":"Tuffanelli, D.L.","year":"1971","unstructured":"Tuffanelli, D. L. (1971). Lupus erythematosus panniculitis (Profundus): clinical and immunologic studies. Arch. Derm., 103, 231-242.","journal-title":"Arch. Derm"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2133.1925.tb10003.x","article-title":"A case of relapsing non-suppurative nodular panniculitis showing phagocytosis of subcutaneous fat cells by macrophages","volume":"37","author":"Weber, F.P.","year":"1925","unstructured":"Weber, F. P. (1925). A case of relapsing non-suppurative nodular panniculitis showing phagocytosis of subcutaneous fat cells by macrophages. Brit. J. Derm., 37, 301-311.","journal-title":"Brit. J. Derm"},{"key":"ref_37","article-title":"Panniculitis and pancytopenia","author":"Wyatt, E.H.","year":"1969","unstructured":"Wyatt, E. H. (1969). Panniculitis and pancytopenia. 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