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The results of the tests for surface markers indicated the T-cell origin of the leukaemic cells in this patient, and this provided a good opportunity to determine the participation of T cells in the various tests proposed for measuring human lymphocyte function.<\/jats:p>","DOI":"10.1136\/jcp.27.11.851","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"851-859","source":"Crossref","is-referenced-by-count":12,"title":["Immunological studies in a case of T-cell leukaemia"],"prefix":"10.1136","volume":"27","author":[{"given":"G.","family":"Stathopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Papamichail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sheldon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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Churchill, London."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1084\/jem.136.1.191","article-title":"Interaction of aggregated V-globulin with B lymphocytes","volume":"136","author":"Dickler, H.B.; Kunkel, H.G.","year":"1972","unstructured":"Dickler, H. B., and Kunkel, H. G. (1972). Interaction of aggregated V-globulin with B lymphocytes. J. exp. Med., 136, 191-196.","journal-title":"J. exp. Med"},{"key":"ref_6","first-page":"97","article-title":"Lymphocyte binding of aggregated IgG and surface Ig staining in chronic lymphocytic leukemia","volume":"14","author":"Dickler, H.B.; Siegal, F.P.; Bentwich, Z.H.; Kunkel, H.G.","year":"1973","unstructured":"Dickler, H. B., Siegal, F. P., Bentwich, Z. H., and Kunkel, H. G. (1973). Lymphocyte binding of aggregated IgG and surface Ig staining in chronic lymphocytic leukemia. Clin. exp. Immunol., 14, 97-106.","journal-title":"Clin. exp. 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Invest., 50, 2368-2375.","journal-title":"J. clin. Invest"},{"key":"ref_11","series-title":"J. exp. Med; A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells","first-page":"207","article-title":"Surface markers on human","volume":"136","author":"Jondal, M.; Holm, G.; Wigzell, H.","year":"1972","unstructured":"Jondal, M., Holm, G., and Wigzell, H. (1972). Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J. exp. Med., 136, 207-215."},{"key":"ref_12","series-title":"Immunoglobulin synthesis as cellular marker of malignant lymphoid cells, In Oncogenesis and Herpesviruses. Proceedings of a Symposium (International Agency for Research on Cancer, Scientific Publications","first-page":"253","volume":"2","author":"Biggs, P.M.; Klein, E.; van Furth, R.; Johansson, B.; Ernberg, I.; Clifford, P.","year":"1972","unstructured":"Klein, E., van Furth, R., Johansson, B., Ernberg, I., and Clifford, P. (1972). Immunoglobulin synthesis as cellular marker of malignant lymphoid cells, In Oncogenesis and Herpesviruses. Proceedings of a Symposium (International Agency for Research on Cancer, Scientific Publications, no. 2) edited by P. M. Biggs, G. de ThM, and L. N. Payne, pp. 253-257. IARC, Lyons."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/230531a0","article-title":"Binding of sheep red blood cells to a large population of human lymphocytes","volume":"230","author":"Lay, W.H.; Mendes, N.F.; Bianco, C.; Nussenzweig, V.","year":"1971","unstructured":"Lay, W. H., Mendes, N. F., Bianco, C., and Nussenzweig, V. (1971). 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