{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:41:46Z","timestamp":1778272906524,"version":"3.51.4"},"reference-count":30,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>To investigate further the role of hepatitis B antigen (HBs Ag) and specific immune complexes in polyarteritis, sera from 55 histologically confirmed cases were tested for the presence of hepatitis B antigen-associated particles and hepatitis B-antibody (anti HBs) by solid phase radio-immunoassay, electron microscopy, and passive haemagglutination. Results of these findings have been correlated with the clinical course of the disease.<\/jats:p>\n                  <jats:p>HBs Ag was detected in 30 patients (54\u00b75%) and anti HBs in 13\/45 (28%). Subtyping in 20 patients revealed that 11 were Y and 9 D. Thirty-seven cases (69%) demonstrated either HBs Ag or anti HBs and 5\/45 (11%) had both. Electron microscopic examination showed 20 nm spherical and tubular particles in sera of 20\/27 patients with 42 nm particles in 11 cases and clumped particles in 12 (60%).<\/jats:p>\n                  <jats:p>No correlation was found between detection of immune complexes and liver disease whereas the presence of coexisting hepatitis B antigen and antibody or aggregated particles was restricted to cases of active vasculitis. Seroconversion or the presence of hepatitis B antibody alone was associated with improved prognosis. Circulating hepatitis B antigen antibody complexes may be responsible for vasculitis or polyarteritis but do not appear to be pathogenic for the liver.<\/jats:p>","DOI":"10.1136\/jcp.27.11.863","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"863-868","source":"Crossref","is-referenced-by-count":187,"title":["The role of circulating hepatitis B antigen\/antibody immune complexes in the pathogenesis of vascular and hepatic manifestations in polyarteritis nodosa"],"prefix":"10.1136","volume":"27","author":[{"given":"Christian G.","family":"Trepo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie J.","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred M.","family":"Prince","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,11,1]]},"reference":[{"key":"ref_1","article-title":"Individual morphological variations seen in","author":"Almeida, J.D.","year":"1972","unstructured":"Almeida, J. D. (1972). Individual morphological variations seen in"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(69)90540-6","article-title":"Immune complexes in hepatitis","volume":"2","author":"Almeida, J.D.; Waterson, A.P.","year":"1969","unstructured":"Almeida, J. D., and Waterson, A. P. (1969). Immune complexes in hepatitis. Lancet, 2, 983-986.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1056\/NEJM197107222850401","article-title":"The pathogenesis of arthritis associated with viral hepatitis complement component studies","volume":"285","author":"Alpert, E.; Isselbacher, K.J.; Schur, P.H.","year":"1971","unstructured":"Alpert, E., Isselbacher, K. J., and Schur, P. H. (1971). The pathogenesis of arthritis associated with viral hepatitis complement component studies. New Engl. J. Med., 285, 185-189.","journal-title":"New Engl. J. 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