{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:20:40Z","timestamp":1764998440261,"version":"3.46.0"},"reference-count":26,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>By cellulose acetate or acrylamide gel electrophoresis it is possible to separate these alkaline phosphatase isoenzymes from serum: [anode] fast liver, slow liver, placenta\/Regan, bone, intestine, bile [cathode]. Heat or chemical inhibition can confirm the differentiation.<\/jats:p>\n                  <jats:p>Normal adult serum always contains slow-liver isoenzyme, and sometimes bone isoenzyme: the latter is always present in serum of children. In hepatobiliary disease slow-liver isoenzyme was always increased: intestinal isoenzyme appeared in many cases of cirrhosis (of blood groups B and 0) but fast-liver and bile isoenzymes were occasionally seen in miscellaneous cases. The findings in other diseases included Regan isoenzyme in six out of 45 cases of malignant disease.<\/jats:p>","DOI":"10.1136\/jcp.27.11.916","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"916-920","source":"Crossref","is-referenced-by-count":7,"title":["Plasma alkaline phosphatase isoenzymes in hepatobiliary disease"],"prefix":"10.1136","volume":"27","author":[{"given":"A. O.","family":"Afonja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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Gut, 13, 702-708.","journal-title":"Gut"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.27.11.916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:19:11Z","timestamp":1764998351000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.27.11.916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,11]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1974,11,1]]},"published-print":{"date-parts":[[1974,11]]}},"alternative-id":["10.1136\/jcp.27.11.916"],"URL":"https:\/\/doi.org\/10.1136\/jcp.27.11.916","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1974,11]]}}}