{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:54:45Z","timestamp":1790877285499,"version":"4.1.0"},"reference-count":26,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,7]]},"abstract":"<jats:p>The structure of 50 small thrombi in femoral valve pockets and the microscopic contents of 35 apparently empty pockets were studied in an attempt to ascertain the nature of the microscopic nidi from which thrombi form and their manner of growth to visible thrombi. Sixteen thrombi had little or no cellular invasion. Most of these recent structures had two main regions, red areas restricted distally in the pocket by the vein wall, and larger white regions comprising most of the thrombus length and often covering the red areas. Red areas are the early sites of cellular adhesion and invasion and the likely sites of origin of most thrombi. They were usually dominated by red cells and fibrin. White zones, which represent propagation growth, are characterized by many foci of platelets with fibrin borders (platelet-fibrin units). Some red areas also contained platelet-fibrin units but they were few and tiny; platelets were not seen in others and one small wholly red thrombus was devoid of platelets. Degenerative changes in platelet-fibrin units were observed, and it is postulated that many become purely fibrin structures. There was no significant evidence of preceding intimal damage in the vein wall. Therefore nidi are laid down on normal endothelium probably on the vein wall near the apex of the pocket. Some pockets, empty of thrombi, contained condensed foci of red cells or tiny fibrin fragments surfaced by endothelial cells and considered to be the remnants of aborted thrombi; a few contained clumps of platelets or leucocytes. It is postulated that any of these may represent the nidi from which thrombi grow. Several thrombi also incorporated large fat droplets, numerous in two. Fat embolic globules derived from fractures are their likely source.<\/jats:p>","DOI":"10.1136\/jcp.27.7.517","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"517-528","source":"Crossref","is-referenced-by-count":203,"title":["The structure and growth of valve-pocket thrombi in femoral veins"],"prefix":"10.1136","volume":"27","author":[{"given":"Simon","family":"Sevitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1974,7,1]]},"reference":[{"key":"ref_1","first-page":"257","article-title":"The role ofthe endothelium in the initial phases of thrombosis","volume":"50","author":"Ashford, T.P.; Freiman, D.G.","year":"1967","unstructured":"Ashford, T. P., and Freiman, D. G. (1967). The role ofthe endothelium in the initial phases of thrombosis. Amer. J. Path., 50, 257-273.","journal-title":"Amer. J. Path"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF01931360","article-title":"Ueber einen neuen Formbestandtheil des Blutes und dessen Rolle bei der Thrombose und der Blutgerinnung","volume":"90","author":"Bizzozero, J.","year":"1882","unstructured":"Bizzozero, J. (1882). Ueber einen neuen Formbestandtheil des Blutes und dessen Rolle bei der Thrombose und der Blutgerinnung. Virchows Arch. path. Anat., 90, 261-332.","journal-title":"Virchows Arch. path. Anat"},{"key":"ref_3","first-page":"214","article-title":"Anatomical localization of venous thrombosis","volume":"36","author":"Cotton, L.T.; Clark, C.","year":"1965","unstructured":"Cotton, L. T., and Clark, C. (1965). Anatomical localization of venous thrombosis. Ann. roy. Coll. Surg. Engl., 36, 214-224.","journal-title":"Ann. roy. Coll. Surg. Engl"},{"key":"ref_4","article-title":"Intraosseous phlebography of the lower limb. Postmortem investigation of thrombotic venous disease","volume":"304","author":"Diener, L.","year":"1971","unstructured":"Diener, L. (1971). Intraosseous phlebography of the lower limb. Postmortem investigation of thrombotic venous disease. Acta Radiologica, suppl. 304.","journal-title":"Acta Radiologica"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"\"39","DOI":"10.1007\/BF01878567","article-title":"Experimentelle Untersuchungen uber Thrombose","volume":"103","author":"Eberth, J.C.; Schimmelbusch, C.","year":"1886","unstructured":"Eberth, J. C., and Schimmelbusch, C. (1886). Experimentelle Untersuchungen uber Thrombose. Virchows Arch. path. Anat., 103, 39-87 and 105. 331-350.","journal-title":"Virchows Arch. path. Anat"},{"key":"ref_6","first-page":"191","article-title":"The structure of natural and experimental thrombi","volume":"36","author":"French, J.E.","year":"1965","unstructured":"French, J. E. (1965). The structure of natural and experimental thrombi. Ann. roy. Coll. Surg. Engl., 36, 191-200.","journal-title":"Ann. roy. Coll. Surg. Engl"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/bjs.18004519102","article-title":"Venous thrombosis of the lower limbs with special reference to bed-rest","volume":"45","author":"Gibbs, N.M.","year":"1957","unstructured":"Gibbs, N. M. (1957). Venous thrombosis of the lower limbs with special reference to bed-rest. Brit. J. Surg., 45, 209-236.","journal-title":"Brit. J. Surg"},{"key":"ref_8","article-title":"Venous Thrombosis and Pulmonary Embolism","author":"Hume, M.; Sevitt, S.; Thomas, D.P.","year":"1970","unstructured":"Hume, M., Sevitt, S., and Thomas, D. P. (1970). Venous Thrombosis and Pulmonary Embolism. Harvard University Press, Cambridge, Mass., and Oxford University Press, London."},{"key":"ref_9","article-title":"On the state of the blood and the blood-vessels in inflammation ascertained by experiments, injections and observations by the microscope. Guy's Hosp","author":"Jones, T.W.","year":"1850","unstructured":"Jones, T. W. (1850). On the state of the blood and the blood-vessels in inflammation ascertained by experiments, injections and observations by the microscope. Guy's Hosp. Rep. (second series), 7, 1-100."},{"key":"ref_10","first-page":"1","article-title":"Some basic observations on venous thrombosis and pulmonary embolism","volume":"93","author":"McLachlin, J.; Paterson, J.C.","year":"1951","unstructured":"McLachlin, J., and Paterson, J. C. (1951). Some basic observations on venous thrombosis and pulmonary embolism. Surg. Gynec. Obstet., 93, 1-8.","journal-title":"Surg. Gynec. Obstet"},{"key":"ref_11","first-page":"\"pp. 321","article-title":"Precipitating factors in venous thrombosis. Surg","volume":"98","author":"Paterson, J.C.","year":"1969","unstructured":"Paterson, J. C. (1969). The pathology of venous thrombi. In Thrombosis, edited by S. Sherry et al., pp. 321-344. Nat. Acad. Sci., Washington D.C. Paterson, J. C., and McLachlin, J. (1954). Precipitating factors in venous thrombosis. Surg. Gynec. Obstet., 98, 96-102.","journal-title":"The pathology of venous thrombi. In Thrombosis; Nat. Acad. Sci., Washington"},{"key":"ref_12","first-page":"55","article-title":"Structural aspects of thrombosis","author":"Poole, J.C.F.","year":"1964","unstructured":"Poole, J. C. F. (1964). Structural aspects of thrombosis. Scient. Basis Med. Ann. Rev., 55-66.","journal-title":"Scient. Basis Med. Ann. Rev"},{"key":"ref_13","first-page":"37","article-title":"Die pathologische Anatomie der Thrombose und Lungenembolie","volume":"41","author":"Sandritter, W.","year":"1962","unstructured":"Sandritter, W. (1962). Die pathologische Anatomie der Thrombose und Lungenembolie. Behringwerk-Mitteil., 41, 37-67.","journal-title":"Behringwerk-Mitteil"},{"key":"ref_14","article-title":"Venous intimal thickenings and thrombosis","author":"Scott, G.B.D.","year":"1956","unstructured":"Scott, G. B. D. (1956). Venous intimal thickenings and thrombosis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/path.1711100207","article-title":"The mechanisms of canalization of deep vein thrombosis","volume":"110","author":"Sevitt, S.","year":"1973","unstructured":"Sevitt, S. (1973a). The mechanisms of canalization of deep vein thrombosis. J. Path., 110, 153-165.","journal-title":"J. Path"},{"key":"ref_16","first-page":"17","volume-title":"Pathology and pathogenesis of deep-vein thrombosis. In Recent Advances in Thrombosis","author":"Sevitt, S.","year":"1973","unstructured":"Sevitt, S. (1973b). Pathology and pathogenesis of deep-vein thrombosis. In Recent Advances in Thrombosis, edited by L. Poller, pp. 17-38. Churchill-Livingstone, Edinburgh and London."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711110102","article-title":"The vascularization of deep-vein thrombi and their fibrous residue: a post-mortem angiographic study","volume":"111","author":"Sevitt, S.","year":"1973","unstructured":"Sevitt, S. (1973c). The vascularization of deep-vein thrombi and their fibrous residue: a post-mortem angiographic study. J. Path., 111, 1-11.","journal-title":"J. Path"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0140-6736(59)91464-3","article-title":"Prevention of venous thrombosis and pulmonary embolism in injured patients","volume":"2","author":"Sevitt, S.; Gallagher, N.G.","year":"1959","unstructured":"Sevitt, S., and Gallagher, N. G. (1959). Prevention of venous thrombosis and pulmonary embolism in injured patients. Lancet, 2, 981-989.","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/bjs.18004821103","article-title":"Venous thrombosis and pulmonary embolism. A clinico-pathological study in injured and burned patients","volume":"48","author":"Sevitt, S.; Gallagher, N.G.","year":"1961","unstructured":"Sevitt, S., and Gallagher, N. G. (1961). Venous thrombosis and pulmonary embolism. A clinico-pathological study in injured and burned patients. Brit. J. Surg., 48, 475-489.","journal-title":"Brit. J. Surg"},{"key":"ref_20","first-page":"267","article-title":"The platelet contribution to arterial and venous thrombosis","volume":"1","author":"Thomas, D.P.","year":"1972","unstructured":"Thomas, D. P. (1972). The platelet contribution to arterial and venous thrombosis. Clin. Haemat., 1, 267-282.","journal-title":"Clin. Haemat"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1172\/JCI103114","article-title":"Studies in intravascular coagulation. III. The pathogenesis of serum-induced venous thrombosis","volume":"34","author":"Wessler, S.","year":"1955","unstructured":"Wessler, S. (1955). Studies in intravascular coagulation. III. The pathogenesis of serum-induced venous thrombosis. J. clin. Invest., 34, 647-651.","journal-title":"J. clin. Invest"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01927438","article-title":"Untersuchungen iiber Thrombose: Bildung der Thromben","volume":"62","author":"Zahn, F.W.","year":"1874","unstructured":"Zahn, F. W. (1874). Untersuchungen iiber Thrombose: Bildung der Thromben. Virchows Arch. path. Anat., 62, 81-124.","journal-title":"Virchows Arch. path. Anat"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3181\/00379727-109-27335","article-title":"Platelet clumping produced by connective tissue suspensions and by collagen","volume":"109","author":"Zucker, M.B.; Borrelli, J.","year":"1962","unstructured":"Zucker, M. B., and Borrelli, J. (1962). Platelet clumping produced by connective tissue suspensions and by collagen. Proc. Soc. exp. biol. Med., 109, 779-787.","journal-title":"Proc. Soc. exp. biol. Med"},{"key":"ref_24","article-title":"The June 1974 Issue","unstructured":"The June 1974 Issue"},{"key":"ref_25","article-title":"ISSUE CONTAINS THE FOLLOWING PAPERS","author":"THE, J.U.N.E.","year":"1974","unstructured":"THE JUNE 1974 ISSUE CONTAINS THE FOLLOWING PAPERS"},{"key":"ref_26","article-title":"The Association of Clinical Pathologists: 92nd general meeting Copies are still avaiable and may be obtained from the PUBLISHING MANAGER","unstructured":"The Association of Clinical Pathologists: 92nd general meeting Copies are still avaiable and may be obtained from the PUBLISHING MANAGER, BRITISH MEDICAL ASSOCIATION, TAVISTOCK SQUARE, LONDON, WC1H 9JR, price \u00a31-05."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.27.7.517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:22:29Z","timestamp":1765596149000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.27.7.517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,7]]},"references-count":26,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1974,7,1]]},"published-print":{"date-parts":[[1974,7]]}},"alternative-id":["10.1136\/jcp.27.7.517"],"URL":"https:\/\/doi.org\/10.1136\/jcp.27.7.517","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,7]]}}}