{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:46:39Z","timestamp":1785545199746,"version":"3.56.0"},"reference-count":11,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,7]]},"abstract":"<jats:p>Type I hyperoxaluria results from reduced activity of \u03b1-ketoglutarate: glyoxylate carboligase, which is necessary for the synergistic decarboxylation of glyoxylate and \u03b1-ketoglutarate to \u03b1-hydroxy-\u03b2-keto-adipate.<\/jats:p>\n                  <jats:p>Since thiamine pyrophosphate is a cofactor in the reaction, thiamine deficiency might be expected to result in tissue oxalosis. However, there was no significant increase in the incidence of renal oxalosis in 15 patients with Wernicke's encephalopathy at necropsy compared with controls.<\/jats:p>\n                  <jats:p>It is possible that hyperoxaluria was present in these thiamine-deficient patients but at a urine concentration below that necessary for calcium oxalate deposition. It is also possible that the severity of the thiamine deficit required for hyperoxaluria exceeds that for the neuronal and cardiac manifestations.<\/jats:p>","DOI":"10.1136\/jcp.27.7.558","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"558-559","source":"Crossref","is-referenced-by-count":7,"title":["Thiamine deficiency and oxalosis"],"prefix":"10.1136","volume":"27","author":[{"given":"William R.","family":"Salyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane C.","family":"Salyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1974,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/ajcn\/12.6.406","article-title":"The effects of an induced pyridoxine and pantothenic acid deficiency on excretions of oxalic and xanthurenic acids in the urine","volume":"12","author":"Faber, S.R.; Feitler, W.W.; Bleiler, R.E.; Ohlson, M.A.; Hodges, R.E.","year":"1963","unstructured":"Faber, S. R., Feitler, W. W., Bleiler, R. E., Ohlson, M. A., and Hodges, R. E. (1963). The effects of an induced pyridoxine and pantothenic acid deficiency on excretions of oxalic and xanthurenic acids in the urine. Amer. J. clin. Nutri., 12, 406-412.","journal-title":"Amer. J. clin. Nutri"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0083-6729(08)60353-2","article-title":"Vitamin B, and oxalate metabolism","volume":"22","author":"Gershoff, S.N.","year":"1964","unstructured":"Gershoff, S. N. (1964). Vitamin B, and oxalate metabolism. Vit. and Horm., 22, 581-589.","journal-title":"Vit. and Horm"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0002-9343(59)90062-2","article-title":"Vitamin B, deficiency and oxalate nephrocalcinosis in the cat","volume":"27","author":"Gershoff, S.N.; Faragalla, F.F.; Nelson, D.A.; Andrus, S.B.","year":"1959","unstructured":"Gershoff, S. N., Faragalla, F. F., Nelson, D. A., and Andrus, S. B. (1959). Vitamin B, deficiency and oxalate nephrocalcinosis in the cat. Amer. J. Med., 27, 72-80.","journal-title":"Amer. J. Med"},{"key":"ref_4","first-page":"347","article-title":"Histochemical identification of calcium oxalate","volume":"74","author":"Johnson, F.B.; Pani, K.","year":"1962","unstructured":"Johnson, F. B., and Pani, K. (1962). Histochemical identification of calcium oxalate. Arch. Path., 74, 347-351.","journal-title":"Arch. Path"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1073\/pnas.57.4.1123","article-title":"Deficiency of 2 oxyglutarate: glyoxylate carboligase activity in primary hyperoxaluria","volume":"57","author":"Koch, J.; Stokstad, E.L.R.; Williams, H.E.; Smith, L.H.","year":"1967","unstructured":"Koch, J., Stokstad, E. L. R., Williams, H. E., and Smith, L. H. (1967). Deficiency of 2 oxyglutarate: glyoxylate carboligase activity in primary hyperoxaluria. Proc. nat. Acad. Sci. (Wash.) 57, 1123-1129.","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1042\/bj0820429","article-title":"Studies on experimental thiamine deficiency. Trends of ketoacid formation and detection of glyoxylic acid","volume":"82","author":"Liang, C.","year":"1962","unstructured":"Liang, C. (1962). Studies on experimental thiamine deficiency. Trends of ketoacid formation and detection of glyoxylic acid. Biochem. J., 82, 429-434.","journal-title":"Biochem. J"},{"key":"ref_7","first-page":"518","article-title":"Vitamins and deficiency diseases","author":"Pinkerton, H.","year":"1971","unstructured":"Pinkerton, H. (1971). Vitamins and deficiency diseases. In Pathology, Mosby, St. Louis. 6th ed., edited by W. A. D. Anderson, pp. 518-519.","edition":"6th ed"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/ki.1973.80","article-title":"Oxalosis as a complication of chronic renal failure","volume":"4","author":"Salyer, W.R.; Keren, D.","year":"1973","unstructured":"Salyer, W. R., and Keren, D. (1973). Oxalosis as a complication of chronic renal failure. Kidney International, 4, 61-66.","journal-title":"Kidney International"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0002-9343(68)90207-6","article-title":"Disordsrs of oxalate metabolism","volume":"45","author":"Williams, H.E.; Smith, Jr, L.H.","year":"1968","unstructured":"Williams, H. E., and Smith, L. H., Jr. (1968a). Disordsrs of oxalate metabolism. Amer. J. Med., 45, 715-735.","journal-title":"Amer. J. Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1056\/NEJM196802012780502","article-title":"L-glyceric aciduria: a new genetic variant of primary hyperoxaluria","volume":"278","author":"Williams, H.E.; Smith, Jr, L.H.","year":"1968","unstructured":"Williams, H. E., and Smith, L. H., Jr. (1968b). L-glyceric aciduria: a new genetic variant of primary hyperoxaluria. New Engl. J. Med., 278, 233-239.","journal-title":"New Engl. J. Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0002-9343(69)90222-8","article-title":"Normocalcemic primary hyperparathyroidism","volume":"47","author":"Wills, M.R.; Pak, C.Y.C.; Hammond, W.G.; Bartler, F.C.","year":"1969","unstructured":"Wills, M. R., Pak, C. Y. C., Hammond, W. G., and Bartler, F. C. (1969). Normocalcemic primary hyperparathyroidism. Amner. J. Med., 47, 384-391.","journal-title":"Amner. J. 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