{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:00:49Z","timestamp":1777543249836,"version":"3.51.4"},"reference-count":12,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,8]]},"abstract":"<jats:p>A controlled trial of continuous chelation therapy in regularly transfused children with homozygous \u03b2-thalassaemia has been in progress at the Hospital for Sick Children since April 1966. In the sixth and seventh years of the trial the effect of this treatment on iron overload has been assessed by estimating serum ferritin levels and liver iron concentrations in both chelator-treated and control groups. When compared with non-chelated controls, results of both these estimations were invariably lower in the chelated group. However, all the results in both groups were very high, and fell within the ranges observed in untreated idiopathic haemochromatosis. A close correlation was found between serum ferritin levels and liver iron concentrations in these children, indicating that serum ferritin is a valuable alternative to liver iron concentration in the assessment of visceral iron overload, even when massive tissue siderosis is present.<\/jats:p>","DOI":"10.1136\/jcp.27.8.652","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"652-655","source":"Crossref","is-referenced-by-count":86,"title":["Serum ferritin in children with thalassaemia regularly transfused"],"prefix":"10.1136","volume":"27","author":[{"given":"E. A.","family":"Letsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Worwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/jcp.25.4.326","article-title":"An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload","volume":"25","author":"Addison, G.M.; Beamish, M.R.; Hales, C.N.; Hodgkins, M.; Jacobs, A.; Llewellin, P.","year":"1972","unstructured":"Addison, G. M., Beamish, M. R., Hales, C. N., Hodgkins, M., Jacobs, A., and Llewellin, P. (1972). An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J. clin. Path., 25, 326-329.","journal-title":"J. clin. Path"},{"issue":"2","key":"ref_2","article-title":"Iron overload: clinical aspects evaluation and treatment","volume":"2","author":"Barry, M.","year":"1973","unstructured":"Barry, M. (1973). Iron overload: clinical aspects evaluation and treatment. Clin. Haemat., 2, no. 2.","journal-title":"Clin. Haemat"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/gut.15.5.411","article-title":"Liver iron concentration, stainable iron, and total body storage iron","volume":"15","author":"Barry, M.","year":"1974","unstructured":"Barry, M. (1974). Liver iron concentration, stainable iron, and total body storage iron. Gut, 15, 411-415.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/bmj.2.5909.16","article-title":"Long-term chelation therapy in thalassaemia major: the effect on liver iron concentration, liver histology and clinical progress","volume":"2","author":"Barry, M.; Flynn, D.M.; Letsky, E.A.; Risdon, R.A.","year":"1974","unstructured":"Barry, M., Flynn, D. M., Letsky, E. A., and Risdon, R. A. (1974). Long-term chelation therapy in thalassaemia major: the effect on liver iron concentration, liver histology and clinical progress. Brit. med. J., 2, 16.","journal-title":"Brit. med. J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/path.1700740202","article-title":"Transfusional siderosis: the effects of excessive iron deposits on the tissues","volume":"74","author":"Cappell, D.F.; Hutchison, H.E.; Jowett, M.","year":"1957","unstructured":"Cappell, D. F., Hutchison, H. E., and Jowett, M. (1957). Transfusional siderosis: the effects of excessive iron deposits on the tissues.. J. Path. Bact., 74, 245-264.","journal-title":"J. Path. Bact"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1172\/JCI102639","article-title":"Iron metabolism: iron stores in man as measured by phlebotomy","volume":"31","author":"Haskins, D.; Stevens, Jr., A.R.; Finch, S.; Finch, C.A.","year":"1952","unstructured":"Haskins, D., Stevens, A. R., Jr., Finch, S., and Finch, C. A. (1952). Iron metabolism: iron stores in man as measured by phlebotomy. J. clin. Invest., 31, 543-547.","journal-title":"J. clin. Invest"},{"key":"ref_7","first-page":"423","article-title":"Development of pigmentary cirrhosis in Codey's anemia","volume":"55","author":"Howell, J.; Wyatt, J.P.","year":"1953","unstructured":"Howell, J., and Wyatt, J. P. (1953). Development of pigmentary cirrhosis in Codey's anemia. Arch. Path., 55, 423-431.","journal-title":"Arch. Path"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/bmj.4.5834.206","article-title":"Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload","volume":"4","author":"Jacobs, A.; Miller, F.; Worwood, M.; Beamish, M.R.; Wardrop, C.A.","year":"1972","unstructured":"Jacobs, A., Miller, F., Worwood, M., Beamish, M. R., and Wardrop, C. A. (1972). Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Brit. med. J., 4, 206-211.","journal-title":"Brit. med. J"},{"key":"ref_9","first-page":"343","article-title":"Serum ferritin in patients with iron overload and with acute and chronic liver disease","volume":"15","author":"Prieto, J.; Barry, M.; Sherlock, S.","year":"1974","unstructured":"Prieto, J., Barry, M., and Sherlock, S. (1974). Serum ferritin in patients with iron overload and with acute and chronic liver disease. (Abstr.) Gut, 15, 343.","journal-title":"(Abstr.) Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/jcp.26.10.770","article-title":"Serum ferritin concentration and iron stores in normal subjects","volume":"26","author":"Walters, G.O.; Miller, F.M.; Worwood, M.","year":"1973","unstructured":"Walters, G. O., Miller, F. M., and Worwood, M. (1973). Serum ferritin concentration and iron stores in normal subjects. J. clin. Path., 26, 770-772.","journal-title":"J. clin. Path"},{"key":"ref_11","article-title":"The Thalassaemia Syndromes, 2nd col","author":"Weatherall, D.J.; Clegg, J.B.","year":"1972","unstructured":"Weatherall, D. J., and Clegg, J. B. (1972). The Thalassaemia Syndromes, 2nd col. Blackwell, Oxford."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1700820102","article-title":"The effect of long survival on the pathology of thalassaemia major","volume":"82","author":"Witzleben, C.L.; Wyatt, J.P.","year":"1961","unstructured":"Witzleben, C. L., and Wyatt, J. P. (1961). The effect of long survival on the pathology of thalassaemia major. J. Path. Bact., 82, 1-12.","journal-title":"J. Path. 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