{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:25:48Z","timestamp":1764998748603,"version":"3.46.0"},"reference-count":34,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,9]]},"abstract":"<jats:p>The distribution of mucosal changes in adult coeliac disease have been studied in 24 cases within four hours of death. There were six patients on a normal diet who showed flat mucosa in the jejunum, convolutions in the middle third, and digitate villi in the terminal ileum. A more extensive distribution of flat mucosa and convolutions involving most of the small intestine was noted in one case. Eighteen patients had been treated with a gluten-free diet and 11 had responded well clinically and histologically. No evidence of flat mucosa was discovery at necropsy in six of these.<\/jats:p>\n                  <jats:p>Attention is drawn to the high incidence of malignancy in this series (13 out of 24 cases). Other complications of adult coeliac disease are discussed briefly.<\/jats:p>","DOI":"10.1136\/jcp.27.9.710","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"710-721","source":"Crossref","is-referenced-by-count":36,"title":["Necropsy studies on adult coeliac disease"],"prefix":"10.1136","volume":"27","author":[{"given":"H.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1001\/jama.1947.02880340013004","article-title":"Clinical and pathological studies in sprue","volume":"134","author":"Adlersberg, D.; Schein, J.","year":"1947","unstructured":"Adlersberg, D., and Schein, J. (1947). Clinical and pathological studies in sprue. J. Amer. med. Ass., 134, 1459-1467.","journal-title":"J. Amer. med. Ass"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1056\/NEJM196705042761802","article-title":"Intestinal ulceration-a complication of celiac disease","volume":"276","author":"Bayless, T.M.; Kapelowitz, R.F.; Shelley, W.M.; Ballinger, W.F.; Hendrix, T.R.","year":"1967","unstructured":"Bayless, T. M., Kapelowitz, R. F., Shelley, W. M., Ballinger, W. F., and Hendrix, T. R. (1967). Intestinal ulceration-a complication of celiac disease. New Engl. J. Med., 276, 996-1002.","journal-title":"New Engl. J. Med"},{"key":"ref_3","first-page":"\"481","article-title":"Anatomopathologie de L'intestin grele dans les diarrhees graisseuses idiopathiques","volume":"13","author":"Boels, W.; Tverdy, G.","year":"1950","unstructured":"Boels, W., and Tverdy, G. (1950). Anatomopathologie de L'intestin grele dans les diarrhees graisseuses idiopathiques. Acta gastroent. belg., 13, 481-505 (supplement, 1, 83-107).","journal-title":"Acta gastroent. belg"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0140-6736(69)91192-1","article-title":"Neoplasia and the coeliac syndrome in adults","volume":"1","author":"Brunt, P.W.; Sircus, W.; MacLean, N.","year":"1969","unstructured":"Brunt, P. W., Sircus, W., and MacLean, N. (1969). Neoplasia and the coeliac syndrome in adults. Lancet, 1, 180-186.","journal-title":"Lancet"},{"key":"ref_5","first-page":"299","article-title":"Adult coeliac disease","volume":"1","author":"Cooke, W.T.","year":"1968","unstructured":"Cooke, W. T. (1968). Adult coeliac disease. Prog. Gastroent. 1, 299-338.","journal-title":"Prog. Gastroent"},{"key":"ref_6","first-page":"1","article-title":"Non-specific enterocolitis","volume":"24","author":"Cooke, W.T.; Brooke, B.N.","year":"1955","unstructured":"Cooke, W. T., and Brooke, B. N. (1955). Non-specific enterocolitis. Quart. J. 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Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0016-5085(57)80087-0","article-title":"Previously undescribed clinical and postmortem observations in nontropical sprue; possible role of prolonged corticosteroid therapy","volume":"32","author":"Himes, H.W.; Gabriel, J.B.; Adlersberg, D.","year":"1957","unstructured":"Himes, H. W., Gabriel, J. B., Adlersberg, D. (1957). Previously undescribed clinical and postmortem observations in nontropical sprue; possible role of prolonged corticosteroid therapy. Gastroenterology, 32, 60-71.","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1177\/003591576305601211","article-title":"The histology of intestinal biopsies","volume":"56","author":"Hourihane, D.O.'B.","year":"1963","unstructured":"Hourihane, D. O'B. (1963). The histology of intestinal biopsies. Proc. roy. Soc. Med., 56, 1073-1077.","journal-title":"Proc. roy. Soc. 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Gastroenterology, 47, 573-589.","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1136\/gut.12.11.938","article-title":"Intestinal malabsorption and the skin","volume":"12","author":"Marks, J.; Shuster, S.","year":"1971","unstructured":"Marks, J., and Shuster, S. (1971). Intestinal malabsorption and the skin. Gut, 12, 938-947.","journal-title":"Gut"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/S0140-6736(66)91692-8","article-title":"Small-bowel changes in dermatitis herpetiformis","volume":"2","author":"Marks, J.; Shuster, S.; Watson, A.J.","year":"1966","unstructured":"Marks, J., Shuster, S., and Watson, A. J. (1966). Small-bowel changes in dermatitis herpetiformis. Lancet, 2, 1280-1282.","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2141.1970.tb06972.x","article-title":"Splenic function in adult coeliac disease","volume":"19","author":"Marsh, G.W.; Stewart, J.S.","year":"1970","unstructured":"Marsh, G. W., and Stewart, J. S. (1970). Splenic function in adult coeliac disease. Brit. J. Haemat., 19, 445-457.","journal-title":"Brit. J. Haemat"},{"key":"ref_22","first-page":"875","article-title":"The association of splenic atrophy and intestinal malabsorption","volume":"92","author":"Martin, J.B.; Bell, H.E.","year":"1965","unstructured":"Martin, J. B., and Bell, H. E. (1965). The association of splenic atrophy and intestinal malabsorption. Canad. med. Ass. J., 92, 875-878.","journal-title":"Canad. med. Ass. 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J"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/00365521.1966.11800614","article-title":"Jejunal biopsy: criteria and significance","volume":"1","author":"Roy-Choudhury, D.C.; Cooke, W.T.; Tan, D.T.; Banwell, J.G.; Smits, B.J.","year":"1966","unstructured":"Roy-Choudhury, D. C., Cooke, W. T., Tan, D. T., Banwell, J. G., and Smits, B. J. (1966). Jejunal biopsy: criteria and significance. Scand. J. Gastroent., 1, 57-74.","journal-title":"Scand. J. Gastroent"},{"key":"ref_26","first-page":"2515","article-title":"Biopsia duodenal por aspiraci6n bajo control radiosc6pico","volume":"42","year":"1955","unstructured":"Royer, M., Croxatto, 0. C., Biempica, L., and Balcazar-Morrison, A. J. (1955). Biopsia duodenal por aspiraci6n bajo control radiosc6pico. Prens. med. argent., 42, 2515-2519.","journal-title":"Prens. med. argent"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0140-6736(56)91854-2","article-title":"Duodenal biopsy","volume":"1","author":"Shiner, M.","year":"1956","unstructured":"Shiner, M. (1956). Duodenal biopsy. Lancet, 1, 17-19.","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0140-6736(68)90181-5","article-title":"Coeliac syndrome in dermatitis herpetiformis","volume":"1","author":"Shuster, S.; Watson, A.J.; Marks, J.","year":"1968","unstructured":"Shuster, S., Watson, A. J., and Marks, J. (1968). Coeliac syndrome in dermatitis herpetiformis. Lancet, 1, 1101-1106.","journal-title":"Lancet"},{"key":"ref_29","article-title":"Neuropathology of the Alimentary T-act","author":"Smith, B.F.","year":"1972","unstructured":"Smith, B. F. (1972). Neuropathology of the Alimentary T-act. Arnold, London."},{"key":"ref_30","article-title":"Non-Tropical Sprue. Levin and Munksgaard, Copenhagen","author":"Thaysen, T.E.H.","year":"1932","unstructured":"Thaysen, T. E. H. (1932). Non-Tropical Sprue. Levin and Munksgaard, Copenhagen. Humphrey Milford, London."},{"key":"ref_31","first-page":"1053","article-title":"Globulinbound amylase","volume":"60","author":"Wilding, P.; Cooke, W.T.; Nicholson, G.I.","year":"1964","unstructured":"Wilding, P., Cooke, W. T., and Nicholson, G. I. (1964). Globulinbound amylase. Ann. intern. Med., 60, 1053-1059.","journal-title":"Ann. intern. Med"},{"article-title":"aged 70, was diagnosed as adult coeliac disease with flat jejunal biopsy in 1964. He was treated with a gluten-free diet for nine years and there was a good response although it is known that he did not stick to his gluten-free diet. He died in 1973 from bacterial endocarditis, bronchopneumonia, and squamous carcinoma of the palate with lymph node metastases. Small intestine, 382-5 cm in length, showed prominent non-obstructing diaphragms. Slight lipofuscin pigmentation and lymphoreticular atrophy were noted: grade 1 67-3 %, grade 2 29-2 %, grade 3 35 %","author":"Male","key":"ref_32","unstructured":"Male, aged 70, was diagnosed as adult coeliac disease with flat jejunal biopsy in 1964. He was treated with a gluten-free diet for nine years and there was a good response although it is known that he did not stick to his gluten-free diet. He died in 1973 from bacterial endocarditis, bronchopneumonia, and squamous carcinoma of the palate with lymph node metastases. Small intestine, 382-5 cm in length, showed prominent non-obstructing diaphragms. Slight lipofuscin pigmentation and lymphoreticular atrophy were noted: grade 1 67-3 %, grade 2 29-2 %, grade 3 35 %."},{"key":"ref_33","article-title":"CASE 26 Female, aged 78, was diagnosed as idiopathic steatorrhoea in 1942 and as adult coeliac disease with flat biopsy in 1961. She was treated with a gluten-free diet in 1965 and had a good response although she did not stick to the diet. She died in 1974 from bronchopneumonia, acute pyelonephritis, and cerebral softening","volume":"694","author":"2 8 9%, 3 0.","year":"grade","unstructured":"CASE 26 Female, aged 78, was diagnosed as idiopathic steatorrhoea in 1942 and as adult coeliac disease with flat biopsy in 1961. She was treated with a gluten-free diet in 1965 and had a good response although she did not stick to the diet. She died in 1974 from bronchopneumonia, acute pyelonephritis, and cerebral softening. Small intestine, 694 cm in length: grade 1 91-1%, grade 2 8 9%, grade 3 0.","journal-title":"Small intestine"},{"article-title":"aged 58, was diagnosed as adult coeliac disease with flat biopsy in November 1973. A gluten-free diet instituted with poor clinical and histological response. He was an alcoholic who did not stick to his gluten-free diet. Died in February 1974 from pulmonary embolism and cerebral softening. Small intestine, 559 cm: grade 1 16-2%, grade 2 51.5%, grade 3 32-3 %. Early incomplete response","author":"Male","key":"ref_34","unstructured":"Male, aged 58, was diagnosed as adult coeliac disease with flat biopsy in November 1973. A gluten-free diet instituted with poor clinical and histological response. He was an alcoholic who did not stick to his gluten-free diet. Died in February 1974 from pulmonary embolism and cerebral softening. Small intestine, 559 cm: grade 1 16-2%, grade 2 51.5%, grade 3 32-3 %. Early incomplete response. Found also to have chronic pancreatitis."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.27.9.710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:24:05Z","timestamp":1764998645000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.27.9.710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,9]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1974,9,1]]},"published-print":{"date-parts":[[1974,9]]}},"alternative-id":["10.1136\/jcp.27.9.710"],"URL":"https:\/\/doi.org\/10.1136\/jcp.27.9.710","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1974,9]]}}}