{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:19:23Z","timestamp":1789532363422,"version":"build-2803163510"},"reference-count":13,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,10]]},"abstract":"<jats:p>Two hundred and thirty-four cerebrospinal fluid (CSF) specimens from 183 different children were analysed for total lactate dehydrogenase (LD) activity and LD isoenzyme distribution. The LD activities were elevated in the CSF of patients with meningitis, especially with bacterial infections, and with central nervous system (CNS) leukaemia. The CSF LD isoenzyme patterns of both groups generally reflected the number and distribution of lymphocytes and granulocytes in the CSF. Increases in CSF LD levels also occurred in patients with other neurological disorders, such as hydrocephalus, raised intracranial pressure, and epileptic seizures. However, no significant increases in CSF LD activity nor abnormality of the isoenzyme distribution were noted in children who had had a non-specific febrile convulsion.<\/jats:p>","DOI":"10.1136\/jcp.28.10.828","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"828-833","source":"Crossref","is-referenced-by-count":35,"title":["Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of children with a variety of neurological disorders."],"prefix":"10.1136","volume":"28","author":[{"given":"P V","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W F","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1975,10,1]]},"reference":[{"key":"ref_1","first-page":"1197","article-title":"Viral infections of the CNS resulted in only mild elevation of the LD activity and leucocyte count (table III). Correspondingly, the LD isoenzyme patterns also varied but slightly","volume":"279","author":"normal, Beaty; N., H.; Oppenheimer, S.","year":"1968","unstructured":"Viral infections of the CNS resulted in only mild elevation of the LD activity and leucocyte count (table III). Correspondingly, the LD isoenzyme patterns also varied but slightly from normal; Beaty, H. N. and Oppenheimer, S. (1968). Cerebrospinalfluid lactic dehydrogenase and its isoenzymes in infections of the central nervous system. New Engl. J. Med., 279, 1197-1202.","journal-title":"New Engl. J. Med; Cerebrospinalfluid lactic dehydrogenase and its isoenzymes in infections of the central nervous system"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1399-0039.1973.tb00977.x","article-title":"A rapid and reliable micro-method of leukoagglutination using papain","volume":"3","author":"Cruikshank, J.A.; Hay, J.","year":"1973","unstructured":"Cruikshank, J. A. and Hay, J. (1973). A rapid and reliable micro-method of leukoagglutination using papain. Tissue Antigens, 3, 57-62.","journal-title":"Tissue Antigens"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/clinchem\/17.4.326","article-title":"Determination of serum lactic dehydrogenase isoenzymes by use of the \"Diagnostest\" cellulose acetate electrophoresis system","volume":"17","author":"di Giorgio, J.","year":"1971","unstructured":"di Giorgio, J. (1971). Determination of serum lactic dehydrogenase isoenzymes by use of the \"Diagnostest\" cellulose acetate electrophoresis system. Clin. Chem., 17, 326-331.","journal-title":"Clin. Chem"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1471-4159.1962.tb09456.x","article-title":"Isoenzymes in different parts of the brain","volume":"9","author":"van der Halm, H.J.","year":"1962","unstructured":"van der Halm, H. J. (1962). Isoenzymes in different parts of the brain. J. 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