{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:17:29Z","timestamp":1758809849133,"version":"3.44.0"},"reference-count":42,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,12]]},"abstract":"<jats:p>Mast cells have been counted in sections of iliac bone from 61 control subjects at necropsy. Mast cells were found in all but three, and the range was 0-33-7, median 1-95 per mm2 marrow. The majority (82%) had less than 4-99 mast cells per mm2 marrow; in 37-7% there was less than 1 mast cell per mm2 marrow. In a group of 45 patients with chronic renal failure there was a significant increase in the numbers of mast cells (P less than 0-001) with a range of 0-96-55-63, median 9-55 per mm2 marrow. Mast cells were common in the areas of marrow fibrosis associated with osteitis fibrosa but this was not the sole cause of the increase since there was also an excess of mast cells in the non-fibrous parts of the marrow. There was a tendency towards greater numbers of mast cells in those cases with most marked osteitis fibrosa in association with the prominent marrow fibrosis, but there was no significant relationship between mast cell numbers and other features of oesteitis fibrosa such as the number of osteoclasts and the amount of woven bone formation. There was no relationship between the numbers of mast cells and the amounts of total bone, ostoid, percentage mineralization of cancellous bone, or the presence of osteomalacia.<\/jats:p>","DOI":"10.1136\/jcp.28.12.947","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"947-955","source":"Crossref","is-referenced-by-count":19,"title":["Quantitative observations on iliac bone marrow mast cells in chronic renal failure."],"prefix":"10.1136","volume":"28","author":[{"given":"K M","family":"Peart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H A","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,12,1]]},"reference":[{"key":"ref_1","first-page":"211","article-title":"Heparin stimulation of bone collagenase activity","volume":"24","author":"Asher, J.D.; Nichols, Jr, G.","year":"1965","unstructured":"Asher, J. 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Y.)"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1001\/jama.1965.03090020072024","article-title":"Multiple fractures associated with long-term sodium heparin therapy","volume":"193","author":"Jaffe, M.D.; Willis, III, P.W.","year":"1965","unstructured":"Jaffe, M. D. and Willis, P. W., III. (1965). Multiple fractures associated with long-term sodium heparin therapy. J. Amer. med. Ass., 193, 158-160.","journal-title":"J. Amer. med. Ass"},{"key":"ref_21","first-page":"826","article-title":"Urticaria pigmentosa associated with widespread sclerosis of the spongiosa of bone","volume":"71","author":"Jensen, W.N.; Lasser, E.C.","year":"1958","unstructured":"Jensen, W. N. and Lasser, E. C. (1958). Urticaria pigmentosa associated with widespread sclerosis of the spongiosa of bone. 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Bone Jt Surg"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0140-6736(72)91523-1","article-title":"Uraemia and mast-cell proliferation (Letter)","volume":"1","author":"Neiman, R.S.; Bischel, M.D.; Lukes, R.J.","year":"1972","unstructured":"Neiman, R. S., Bischel, M. D., and Lukes, R. J. (1972). Uraemia and mast-cell proliferation (Letter). Lanicet, 1, 959.","journal-title":"Lanicet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF02061971","article-title":"An experimental study of mast cells in the rat metaphysis","volume":"9","author":"Rasmussen, P.","year":"1972","unstructured":"Rasmussen, P. (1972). An experimental study of mast cells in the rat metaphysis. Calcif. Tiss. Res., 9, 325-330.","journal-title":"Calcif. Tiss. Res"},{"key":"ref_30","first-page":"213","article-title":"Mastocytes et remaniements du tissu osseux","volume":"22","author":"Rebel, A.; Riberi, P.; Bregeon, P.; Malkani, K.","year":"1974","unstructured":"Rebel, A., Riberi, P., Bregeon, P., and Malkani, K. (1974). Mastocytes et remaniements du tissu osseux. Path. et Biol., 22, 213-220.","journal-title":"Path. et Biol"},{"key":"ref_31","unstructured":"Rockoff, S. D. and Armstrong, J. D., Jr.,(1970).Parathyroid hormone as a stimulus to mast cell accumulation in bone.","article-title":"Parathyroid hormone as a stimulus to mast cell accumulation in bone"},{"key":"ref_32","article-title":"Mastocytosis and the Mast Cell. Karger, Basle and Year","author":"Sagher, F.; Even-Paz, Z.","year":"1967","unstructured":"Sagher, F. and Even-Paz, Z. (1967). Mastocytosis and the Mast Cell. Karger, Basle and Year Book Medical Publishers, Chicago."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF02013739","article-title":"Mouse bone collagenase: the effect of heparin on the amount of enzyme released in tissue culture and on the activity of the enzyme","volume":"12","author":"Sakamoto, S.; Goldhaber, P.; Glimcher, M.J.","year":"1973","unstructured":"Sakamoto, S., Goldhaber, P., and Glimcher, M. J. (1973). Mouse bone collagenase: the effect of heparin on the amount of enzyme released in tissue culture and on the activity of the enzyme. Calcif. Tiss. Res., 12, 247-258.","journal-title":"Calcif. Tiss. Res"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1055\/s-0028-1110442","article-title":"Zur Pathologie der Osteopathie nach Heparinbehandlung","volume":"94","author":"Schuster, J.; Meier-Ruge, W.; Egli, F.","year":"1969","unstructured":"Schuster, J., Meier-Ruge, W., and Egli, F. (1969). 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Iowa State University Press, Ames, Iowa.","edition":"6th edition"},{"key":"ref_40","first-page":"143","article-title":"Radiologic and pathologic bone changes associated with urticaria pigmentosa. Report of a case","volume":"62","author":"Stark, E.; Van Buskirk, F.W.; Daly, J.F.","year":"1956","unstructured":"Stark, E., Van Buskirk, F. W., and Daly, J. F. (1956). Radiologic and pathologic bone changes associated with urticaria pigmentosa. Report of a case. Arch. Path., 62, 143-148.","journal-title":"Arch. Path"},{"key":"ref_41","first-page":"239","article-title":"Accumulation of mast cells in endosteum of bones of calcium-deficient rats","volume":"63","author":"Urist, M.R.; McLean, F.C.","year":"1957","unstructured":"Urist, M. R. and McLean, F. C. (1957). Accumulation of mast cells in endosteum of bones of calcium-deficient rats. Arch. Path., 63, 239-251.","journal-title":"Arch. 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