{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:09:38Z","timestamp":1765714178727,"version":"3.48.0"},"reference-count":31,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,12]]},"abstract":"<jats:p>The blood and bone marrow of a 75-year-old woman with eosinophilia were studied in an attempt to characterize further the entity eosinophilic leukaemia (EL). Haemopoietic cell culture in agar gave patterns of colony size and number and cell morphology indistinguishable from those seen in classical chronic granulocytic leukaemia (CGL). Analysis of myeloid cells showed an extra C group chromosome that proved on Giemsa banding to be number 10. These results suggest that some cases of EL represent a chronic myeloproliferative disease that resembles classical CGL but can be distinguished from it by chromosomal analysis.<\/jats:p>","DOI":"10.1136\/jcp.28.12.956","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"956-961","source":"Crossref","is-referenced-by-count":28,"title":["Agar culture and chromosome analysis of eosinophilic leukaemia."],"prefix":"10.1136","volume":"28","author":[{"given":"J M","family":"Goldman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Najfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K H","family":"Th'ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.7326\/0003-4819-71-4-731","article-title":"Eosinophilic leukemia: report of five cases and review of literature","volume":"71","author":"Benvenisti, D.S.; Ultmann, J.E.","year":"1969","unstructured":"Benvenisti, D. S. and Ultmann, J. E. (1969). Eosinophilic leukemia: report of five cases and review of literature. Ann. intern. Med., 71, 731-745.","journal-title":"Ann. intern. Med"},{"key":"ref_2","first-page":"13","article-title":"In vitro growth of granulocytic and mononuclear colonies from blood of normal individuals","volume":"37","author":"Chervenick, P.A.; Boggs, D.R.","year":"1971","unstructured":"Chervenick, P. A. and Boggs, D. R. (1971). In vitro growth of granulocytic and mononuclear colonies from blood of normal individuals. Blood, 37, 13 1-135.","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","article-title":"The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature","volume":"54","author":"Chusid, J.M.; Dale, D.C.; West, B.C.; Wolff, S.M.","year":"1975","unstructured":"Chusid, J. M., Dale, D. C., West, B. C., and Wolff, S. M. (1975). The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore), 54, 1-27.","journal-title":"Medicine (Baltimore)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/S0140-6736(73)91848-5","article-title":"Acquired trisomy 9","volume":"1","author":"Davidson, W.M.; Knight, L.A.","year":"1973","unstructured":"Davidson, W. M. and Knight, L. A. (1973). Acquired trisomy 9. (Letter). Lancet, 1, 1510.","journal-title":"(Letter). Lancet"},{"key":"ref_5","first-page":"470","article-title":"8-Trisomy in the bone marrow: report of two cases","volume":"3","author":"De La Chapelle, A.; Schroder, J.; Vuopio, P.","year":"1972","unstructured":"De La Chapelle, A., Schroder, J., and Vuopio, P. (1972). 8-Trisomy in the bone marrow: report of two cases. Clin. Genet., 3, 470-476.","journal-title":"Clin. Genet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1001\/archinte.1964.03860090173021","article-title":"Submetacentric chromosome in chronic myelocytic leukemia","volume":"114","author":"Goh, K.O.; Swisher, S.N.; Troup, S.B.","year":"1964","unstructured":"Goh, K. O., Swisher, S. N., and Troup, S. B. (1964). Submetacentric chromosome in chronic myelocytic leukemia. Arch. intern. Med., 114, 439-443.","journal-title":"Arch. intern. Med"},{"key":"ref_7","first-page":"419","article-title":"Chronic myelogenous leukemia cell growth and maturation in liquid culture","volume":"34","author":"Golde, D.W.; Byers, L.A.; Cline, M.J.","year":"1974","unstructured":"Golde, D. W., Byers, L. A., and Cline, M. J. (1974). Chronic myelogenous leukemia cell growth and maturation in liquid culture. Cancer Res., 34, 419-423.","journal-title":"Cancer Res"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V41.1.45.45","article-title":"Growth of human bone marrow in liquid culture","volume":"41","author":"Golde, D.W.; Cline, M.J.","year":"1973","unstructured":"Golde, D. W. and Cline, M. J. (1973). Growth of human bone marrow in liquid culture. Blood, 41, 45-57.","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1974.108","article-title":"In vitro colony forming cells and colony stimulating factor in chronic granulocytic leukaemia","volume":"30","author":"Goldman, J.M.; Th'ng, H.K.; Lowenthal, R.M.","year":"1974","unstructured":"Goldman, J. M., Th'ng, H. K., and Lowenthal, R. M. (1974). In vitro colony forming cells and colony stimulating factor in chronic granulocytic leukaemia. Brit. J. Cancer, 30, 1-12.","journal-title":"Brit. J. Cancer"},{"key":"ref_10","first-page":"485","article-title":"Models for clonal evolution: a study of chronic myelogenous leukemia","volume":"18","author":"de Grouchy, J.; de Nava, C.; Cantu, J.M.; Bilski-Pasquier, G.; Bousser, J.","year":"1966","unstructured":"de Grouchy, J., de Nava, C., Cantu, J. M., Bilski-Pasquier, G., and Bousser, J. (1966). Models for clonal evolution: a study of chronic myelogenous leukemia. Amer. J. hum. Genet., 18, 485-503.","journal-title":"Amer. J. hum. Genet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.7326\/0003-4819-68-6-1220","article-title":"The hypereosinophilic syndrome","volume":"68","author":"Hardy, W.R.; Anderson, R.E.","year":"1968","unstructured":"Hardy, W. R. and Anderson, R. E. (1968). The hypereosinophilic syndrome. Ann. intern. Med., 68, 1220-1229.","journal-title":"Ann. intern. Med"},{"key":"ref_12","first-page":"557","volume-title":"Trisomy 8 in acute myeloblastic leukemia and sideroachrestic anemia. Blood","volume":"43","author":"Jonasson, J.; Gahrton, G.; Lindsten, J.; SimonssonLindemalm, C.; Zech, L.","year":"1974","unstructured":"Jonasson, J., Gahrton, G., Lindsten, J., SimonssonLindemalm, C., and Zech, L. (1974). Trisomy 8 in acute myeloblastic leukemia and sideroachrestic anemia. Blood, 43, 557-563."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0140-6736(74)92564-1","article-title":"Acquired trisomies 12 and","volume":"1","author":"Kaffe, S.; Hsu, L.Y.F.; Hirschhorn, K.","year":"1974","unstructured":"Kaffe, S., Hsu, L. Y. F., and Hirschhorn, K. (1974). Acquired trisomies 12 and 7. (Letter). Lancet, 1, 261-262.","journal-title":"Lancet"},{"key":"ref_14","first-page":"1","article-title":"Techniques for chromosomal analysis. Broadsheet No. 74","author":"Lawler, S.D.","year":"1971","unstructured":"Lawler, S. D. (1971). Techniques for chromosomal analysis. Broadsheet No. 74 (June 1971), pp. 1-7. Association of Clinical Pathologists, London."},{"key":"ref_15","first-page":"957","article-title":"Massachusetts General Hospital","volume":"288","year":"1973","unstructured":"Massachusetts General Hospital (1973). Case records: case 18-1973. New Engl. J. Med., 288, 957-963.","journal-title":"New Engl. J. Med; Case records: case 18-1973"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1601-5223.1974.tb01453.x","article-title":"The banding pattern in Philadelphia chromosome negative chronic myeloid leukaemia","volume":"78","author":"Mitelman, F.; Brandt, L.; Nilsson, P.G.","year":"1974","unstructured":"Mitelman, F., Brandt, L., and Nilsson, P. G. (1974). The banding pattern in Philadelphia chromosome negative chronic myeloid leukaemia. Hereditas (Lund.), 78, 302-304.","journal-title":"Hereditas (Lund.)"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1600-0609.1974.tb00225.x","article-title":"Granulopoiesis in chronic myeloid leukaemia. I. In vitro cloning of blood and bone marrow cells in agar culture","volume":"12","author":"Moberg, D.; Olofsson, T.; Olsson, I.","year":"1974","unstructured":"Moberg, D., Olofsson, T., and Olsson, I. (1974). Granulopoiesis in chronic myeloid leukaemia. I. In vitro cloning of blood and bone marrow cells in agar culture. Scand. J. Haemat., 12, 381-390.","journal-title":"Scand. J. Haemat"},{"key":"ref_18","first-page":"161","volume-title":"Advances in Acute Lcukaemia","author":"Moore, M.A.S.","year":"1974","unstructured":"Moore, M. A. S. (1974). In Advances in Acute Lcukaemia, edited by F. J. Cleton, D. Crowther, and J. S. Malpas, p. 161. North Holland Publishing Company, Oxford."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/jnci\/50.3.603","article-title":"In vitro colony formation by normal and leukemic human hematopoietic cells: characterization of the colony-forming cells","volume":"50","author":"Moore, M.A.S.; Williams, N.; Metcalf, D.","year":"1973","unstructured":"Moore, M. A. S., Williams, N., and Metcalf, D. (1973). In vitro colony formation by normal and leukemic human hematopoietic cells: characterization of the colony-forming cells. J. nat. Cancer Inst., 50, 603-623.","journal-title":"J. nat. Cancer Inst"},{"year":"1970","author":"Paran, M.; Sachs, L.; Barak, Y.; Resnitsky, P.","key":"ref_20","unstructured":"Paran, M., Sachs, L., Barak, Y., and Resnitsky, P. (1970)."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jcp.1040760111","article-title":"Human bone marrow colony growth in agar-gel","volume":"76","author":"Pike, B.L.; Robinson, W.A.","year":"1970","unstructured":"Pike, B. L. and Robinson, W. A. (1970). Human bone marrow colony growth in agar-gel. J. Cell Comp. Physiol., 76, 77-84.","journal-title":"J. Cell Comp. Physiol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00273302","article-title":"Identity of the abnormal F-group chromosome associated with polycythaemia vera","volume":"14","author":"Reeves, B.R.; Lobb, D.S.; Lawler, S.D.","year":"1972","unstructured":"Reeves, B. R., Lobb, D. S., and Lawler, S. D. (1972). Identity of the abnormal F-group chromosome associated with polycythaemia vera. Humangenetik, 14, 159-161.","journal-title":"Humangenetik"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0022-3476(72)80499-2","article-title":"Eosinophilic leukemoid reaction","volume":"80","author":"Rickles, F.R.; Miller, D.R.","year":"1972","unstructured":"Rickles, F. R.. and Miller, D. R. (1972). Eosinophilic leukemoid reaction. J. Pediat., 80, 418-428.","journal-title":"J. Pediat"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0140-6736(73)93247-9","article-title":"Acquired trisomy 9. (Letter)","volume":"2","author":"Rowley, J.D.","year":"1973","unstructured":"Rowley, J. D. (1973a). Acquired trisomy 9. (Letter). Lancer, 2, 390.","journal-title":"Lancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/243290a0","article-title":"A new consistent chromosomal abnormality in CML identified by quinacrine fluorescence and Giemsa staining","volume":"243","author":"Rowley, J.D.","year":"1973","unstructured":"Rowley, J. D. (1973b). A new consistent chromosomal abnormality in CML identified by quinacrine fluorescence and Giemsa staining. Nature (Lond.), 243, 290-293.","journal-title":"Nature (Lond.)"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev.me.21.020170.002115","article-title":"Chromosomal abnormalities in human neoplasia","volume":"21","author":"Sandberg, A.A.; Hossfeld, D.K.","year":"1970","unstructured":"Sandberg, A. A. and Hossfeld, D. K. (1970). Chromosomal abnormalities in human neoplasia. Ann. Rev. Med., 21, 379-408.","journal-title":"Ann. Rev. Med"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/newbio232031a0","article-title":"New technique for distinguishing between human chromosomes","volume":"232","author":"Sumner, A.T.; Evans, H.J.; Buckland, R.A.","year":"1971","unstructured":"Sumner, A. T., Evans, H. J., and Buckland, R. A. (1971). New technique for distinguishing between human chromosomes. Nature [New Biol.J, 232, 31-32.","journal-title":"Nature [New Biol. J"},{"key":"ref_28","first-page":"47","article-title":"Cytogenetic studies in cases of chronic myeloid leukaemia with a previous history of radiation","volume-title":"Current Research in Leukaemias","author":"Tough, I.M.","year":"1965","unstructured":"Tough, I. M. (1965). Cytogenetic studies in cases of chronic myeloid leukaemia with a previous history of radiation. In Current Research in Leukaemias, edited by F. G. J. Hayhoe, pp. 47-54. Cambridge University Press, London."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1182\/blood.V32.5.755.755","article-title":"Clinical implications of cytogenetic variants of chronic myelocytic leukemia (CML)","volume":"32","author":"Whang-Peng, J.; Canellos, G.P.; Carbone, P.P.; Tjio, J.H.","year":"1968","unstructured":"Whang-Peng, J., Canellos, G. P., Carbone, P. P., and Tjio, J. H. (1968). Clinical implications of cytogenetic variants of chronic myelocytic leukemia (CML). Blood, 32, 755-766.","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0002-9343(72)90129-5","article-title":"Pseudoeosinophilia, eosinophilic endocarditis and eosinophilic leukemia","volume":"53","author":"Yam, L.T.; Li, C.Y.; Necheles, T.F.; Katayama, I.","year":"1972","unstructured":"Yam, L. T., Li, C. Y., Necheles, T. F., and Katayama, I. (1972). Pseudoeosinophilia, eosinophilic endocarditis and eosinophilic leukemia. Amer. J. Med., 53, 193-202.","journal-title":"Amer. J. Med"},{"key":"ref_31","first-page":"1","article-title":"Eosinophil function and disorders","volume":"19","author":"Zucker-Franklin, D.","year":"1974","unstructured":"Zucker-Franklin, D. (1974). Eosinophil function and disorders. Advanc. intern. Med., 19, 1-25.","journal-title":"Advanc. intern. Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.28.12.956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:08:04Z","timestamp":1765714084000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.28.12.956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,12]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1975,12,1]]},"published-print":{"date-parts":[[1975,12]]}},"alternative-id":["10.1136\/jcp.28.12.956"],"URL":"https:\/\/doi.org\/10.1136\/jcp.28.12.956","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1975,12]]}}}