{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:25Z","timestamp":1787017105553,"version":"build-2736575974"},"reference-count":40,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,2]]},"abstract":"<jats:p>The serum levels of alpha2-macroglobulin have been measured in normal men and mice and in a number of immunopathological conditions. Normal human concentrations are high in youth, reach their minimum in middle age, and gradually increase with old age. In all age groups the mean is higher in the female than in the male. Conversely, in normal mice the alpha2M level is low in youth, maximum in middle age, and shows a slight depression with old age, and the levels are frequently higher in males than in females; there are also strain variations. In human immunopathological conditions, there are some deviations from the normal alpha2M level but these are seen to be changes from the normal distribution of values around the mean, rather than significant elevation or depression of mean values. In some disease states studied there are differences between the sexes in the deviation from normal. \"Abnormal\" strains of mice had alpha2M levels within the range exhibited by \"normal\" mice but changes in the levels are seen in mice with various myelomas.<\/jats:p>","DOI":"10.1136\/jcp.28.2.133","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"133-139","source":"Crossref","is-referenced-by-count":35,"title":["Normal and pathological serum levels of alpha2-macroglobulins in men and mice."],"prefix":"10.1136","volume":"28","author":[{"given":"A M","family":"Tunstall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1975,2,1]]},"reference":[{"key":"ref_1","article-title":"Alpha2-macroglobulin levels in human serum. 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(hi\/i"},{"key":"ref_7","article-title":"Phfthama,, glutinin (PHA) und Serumproteine in der Lymphocytenkultur","author":"Havemann, K.; Dosch, H.M.; Burger, S.","year":"1970","unstructured":"Havemann, K., Dosch, H. M., and Burger, S. (1970). Phfthama,,glutinin (PHA) und Serumproteine in der Lymphocytenkultur."},{"key":"ref_8","first-page":"\"297","article-title":"Nachsweis von fordernden und hemmenden Serumfakitoren","volume":"153","author":"Housley, J.","year":"1968","unstructured":"Nachsweis von fordernden und hemmenden Serumfakitoren. Z. ges. e.vp. Med., 153. 297-307. Housley, J. (1968). a2-macroglobulin levels in disease in nlan. J. (\/it. Patli., 21, 27-31.","journal-title":"Z. ges. e.vp. 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DIXON"},{"key":"ref_39","article-title":"Control Materials for Clinical Biochemistry","year":"1973","unstructured":"Control Materials for Clinical Biochemistry (5th edition) September 1973 J. F. STEVENS","edition":"5th edition"},{"key":"ref_40","article-title":"Notes on the Quality of Performance of Serum Cholesterol Assays September 1973 s. s","unstructured":"Notes on the Quality of Performance of Serum Cholesterol Assays September 1973 s. s. BROWN"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.28.2.133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:20:52Z","timestamp":1765074052000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.28.2.133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,2]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1975,2,1]]},"published-print":{"date-parts":[[1975,2]]}},"alternative-id":["10.1136\/jcp.28.2.133"],"URL":"https:\/\/doi.org\/10.1136\/jcp.28.2.133","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,2]]}}}