{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:57:24Z","timestamp":1765601844927,"version":"3.48.0"},"reference-count":15,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,3]]},"abstract":"<jats:p>Bladder biopsies from six boys without a history of urinary tract infection were taken during hypospadias repair operations and examined by electron microscopy. The ultrastructure of the epithelium, which was presumed to represent the normal, is described in detail and compared with the reported findings in other mammalian species. The appearances are generally similar although in our material the luminal membrane of the superficial cells was thicker than that surrounding the other epithelial cells but not asymmetrical. We observed membrane-coating granules which have not been reported before in bladder epithelium. The appearances of the normal bladder are compared to those seen in 24 children with urinary infection. In the presence of acute infection in large heterogeneous secondary lysosomes which are present in the intermediate and superficial cells of the normal bladder are reduced in number and the amount of rough endoplasmic reticulum is increased.<\/jats:p>","DOI":"10.1136\/jcp.28.3.176","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"176-188","source":"Crossref","is-referenced-by-count":6,"title":["An ultrastructural study of the urinary bladder in children correlated with histological, bacteriological, and clinical findings."],"prefix":"10.1136","volume":"28","author":[{"given":"M","family":"Haynes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Trott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Hirst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,3,1]]},"reference":[{"key":"ref_1","first-page":"354361","article-title":"The human urinary bladder mucosa","volume":"1","author":"Battifora, H.; Eisenstein, R.; McDonald, J.H.","year":"1964","unstructured":"Battifora, H., Eisenstein, R., and McDonald, J. H. (1964). The human urinary bladder mucosa. Invest. Urol., 1, 354361.","journal-title":"Invest. Urol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/1097-0142(197101)27:1<71::AID-CNCR2820270112>3.0.CO;2-E","article-title":"Proliferation and ultrastructure of papillary transitional cell carcinoma of the human bladder","volume":"27","author":"Fulker, M.J.; Cooper, E.H.; Tanaka, T.","year":"1971","unstructured":"Fulker, M. J., Cooper, E. H., and Tanaka, T. (1971). Proliferation and ultrastructure of papillary transitional cell carcinoma of the human bladder. 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The function of the golgi complex in transitional epithelium: Synthesis of the thick cell membrane. J. cell. Biol., 30, 623-643.","journal-title":"J. cell. Biol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/2241304a0","article-title":"Hexagonal lattice of subunits in the thick luminal membrane of the rat urinary bladder","volume":"224","author":"Hicks, R.M.; Ketterer, B.","year":"1969","unstructured":"Hicks, R. M., and Ketterer, B. (1969). Hexagonal lattice of subunits in the thick luminal membrane of the rat urinary bladder. Nature (Land.), 224, 1304-1305.","journal-title":"Nature (Land.)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000278999","article-title":"An electron microscopic study on the transitional cell carcinoma of human urinary bladder","volume":"15","author":"Kashiwai, K.; Yano, H.; Kusunoki, T.","year":"1963","unstructured":"Kashiwai, K., Yano, H., and Kusunoki, T. (1963). 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