{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:40:22Z","timestamp":1765701622390,"version":"3.48.0"},"reference-count":10,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,4]]},"abstract":"<jats:p>Bacteriocin typing has been described previously and proposed for typing gonococci. A survey has been made of 150 strains of N. gonorrhoeae from various places to determine the feasibility of a gonocin typing system. All strains were found to produce an inhibitory substance which inhibited all strains of gonococci tested, one strain of Neisseria flavescens, two strains of Neisseria meningitidis, as well as the producing strain itself. The inhibitory activity was enhanced by supplementary glucose, reduced by supplementary serum, and unaffected by the addition of HEPES buffer, by the temperature of incubation, or by the exposure of potential producer strains to sublethal concentrations of mitomycin C. This nonspecific inhibitory activity differed from that of a putative bacteriocin produced by a strain of N. meningitidis, in that the latter inhibited most other meningococci but not the producer strain itself. Bacteriocinogeny has not yet been convincingly demonstrated in N. gonorrhoeae, and gonocin typing has not yet been shown to be feasible. Production of the nonspecific inhibitor may have obscured past attempts to demonstrate type-specific gonococcal bacteriocin.<\/jats:p>","DOI":"10.1136\/jcp.28.4.274","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"274-278","source":"Crossref","is-referenced-by-count":14,"title":["Reevaluation of bacteriocinogeny in Neisseria gonorrhoeae."],"prefix":"10.1136","volume":"28","author":[{"given":"J S","family":"Knapp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Falkow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K K","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,4,1]]},"reference":[{"key":"ref_1","article-title":"Experiments in Microbial Genetics","author":"Clowes, R.C.; Hayes, W.","year":"1968","unstructured":"Clowes, R. C., and Hayes, W. (1968). Experiments in Microbial Genetics Wiley, New York."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/infdis\/124.1.26","article-title":"Identification of an epidemic strain of Neisseria meningitidis by bacteriocin typing","volume":"124","author":"Counts, G.W.; Seeley, L.; Beaty, H.N.","year":"1971","unstructured":"Counts, G. W., Seeley, L., and Beaty, H. N. (1971). Identification of an epidemic strain of Neisseria meningitidis by bacteriocin typing. J. infect. Dis., 124, 26-32.","journal-title":"J. infect. Dis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/jcp.25.1.60","article-title":"Bacteriocins from Netisseria gonorrhoeae and their possible role in epidemiological studies","volume":"25","author":"Flynn, J.; McEnteggart, M.C.","year":"1971","unstructured":"Flynn, J., and McEnteggart, M. C. (1971). Bacteriocins from Netisseria gonorrhoeae and their possible role in epidemiological studies. J. clin. Path. 25, 60-61.","journal-title":"J. clin. Path"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1128\/IAI.6.5.889-892.1972","article-title":"Autosensitivity of Pseudomonas aeruginosa to its own pyocin","volume":"6","author":"Goodwin, K.; Levin, R.E.; Doggett, R.G.","year":"1972","unstructured":"Goodwin, K., Levin, R. E., and Doggett, R. G. (1972). Autosensitivity of Pseudomonas aeruginosa to its own pyocin. Infect. and Immun. 6, 889-892.","journal-title":"Infect. and Immun"},{"key":"ref_5","first-page":"1840","article-title":"Etude du mode de fixation des colicins et des pyocins sur les bacteries sensibles","volume":"251","author":"Hamon, Y.; Peron, Y.","year":"1960","unstructured":"Hamon, Y., and Peron, Y. (1960). Etude du mode de fixation des colicins et des pyocins sur les bacteries sensibles. C.R. Acad. Sci. (Paris) 251, 1840-1842.","journal-title":"C. R. Acad. Sci. (Paris)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1128\/JB.91.5.1696-1699.1966","article-title":"Bacteriocin production by strains of Neisseria meningitidis","volume":"91","author":"Kingsbury, D.T.","year":"1966","unstructured":"Kingsbury, D. T. (1966). Bacteriocin production by strains of Neisseria meningitidis. J. Bact. 91, 1696-1699.","journal-title":"J. Bact"},{"key":"ref_7","first-page":"128","article-title":"Gonocin production by Neisseria gonorrhoeae","author":"Lawton, W.D.; Gaafar, H.A.","year":"1973","unstructured":"Lawton, W. D., and Gaafar, H. A. (1973). Gonocin production by Neisseria gonorrhoeae. (Abstr.), Annual Meeting, American Society of Microbiology p. 128."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1128\/br.29.1.24-45.1965","article-title":"The bacteriocins","volume":"29","author":"Reeves, P.","year":"1965","unstructured":"Reeves, P. (1965). The bacteriocins. Bact. Rev., 29, 24-45.","journal-title":"Bact. Rev"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1128\/AEM.13.2.171-174.1965","article-title":"Neisseria gonorrhoeae identification in direct smears by a fluorescent antibodycounterstain method","volume":"13","author":"A., White L.; Kellogg, Jr, D.S.","year":"1965","unstructured":"White L. A., and Kellogg, D. S., Jr. (1965). Neisseria gonorrhoeae identification in direct smears by a fluorescent antibodycounterstain method. Appl. Microbiol., 13, 171-174.","journal-title":"Appl. Microbiol"},{"key":"ref_10","first-page":"481","article-title":"have also recently observed growth inhibition among strains of N. gonorrhoeae due to longchain free fatty acids and monoacyl phosphatidylethanolamine, and have been unable to detect bacteriocin production by gonococci","volume":"10","author":"Walstad, Reitz; Immun, Sparling (Infect","year":"1974","unstructured":"Walstad, Reitz, and Sparling (Infect Immun, 10, 481-488, 1974) have also recently observed growth inhibition among strains of N. gonorrhoeae due to longchain free fatty acids and monoacyl phosphatidylethanolamine, and have been unable to detect bacteriocin production by gonococci."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.28.4.274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:38:10Z","timestamp":1765701490000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.28.4.274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,4]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1975,4,1]]},"published-print":{"date-parts":[[1975,4]]}},"alternative-id":["10.1136\/jcp.28.4.274"],"URL":"https:\/\/doi.org\/10.1136\/jcp.28.4.274","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1975,4]]}}}