{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:37:41Z","timestamp":1765075061881,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,4]]},"abstract":"<jats:p>The case histories and blood pictures of two patients who had cardiac lesions, septicaemia, and renal failure and terminally developed a leucoerythroblastic anaemia with megloblastic features associated with multinucleate erythroblasts, are described. Though folate deficiency may have made a minor contribution to the blood abnormalities, it is considered that some other disturbance in erythropoiesis was responsible for the bizarre blood and bone marrow changes in these patients. Similar cases reported in the earlier literature are reviewed.<\/jats:p>","DOI":"10.1136\/jcp.28.4.324","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"324-331","source":"Crossref","is-referenced-by-count":9,"title":["Unusual megaloblastic anaemia wiht multinucleate erythroblasts: two cases with septicaemia and acute renal failure."],"prefix":"10.1136","volume":"28","author":[{"given":"M","family":"Saary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Sissons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W A","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A V","family":"Hoffbrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,4,1]]},"reference":[{"key":"ref_1","first-page":"793","article-title":"The clinical significance of cellular gigantism in human erythropoiesis","volume":"32","author":"Berman, L.","year":"1947","unstructured":"Berman, L. (1947). The clinical significance of cellular gigantism in human erythropoiesis. J. Lab. clin. Med., 32, 793-806.","journal-title":"J. Lab. clin. Med"},{"key":"ref_2","first-page":"308","article-title":"The Megaloblastic Anaemias","author":"Chanarin, I.","year":"1969","unstructured":"Chanarin, I. (1969). The Megaloblastic Anaemias, pp. 308-319. Blackwell, Oxford."},{"key":"ref_3","first-page":"65","article-title":"Anemies r6fractaires: enzymopathies acquises des cellules souches hematopletiques","volume":"9","author":"Dreyfus, B.; Rochant, H.; Sultan, C.","year":"1969","unstructured":"Dreyfus, B., Rochant, H., and Sultan, C. (1969). Anemies r6fractaires: enzymopathies acquises des cellules souches hematopletiques. Nouv. Rev. frac. Hemat., 9, 65-85.","journal-title":"Nouv. Rev. frac. Hemat"},{"issue":"1","key":"ref_4","first-page":"69","volume":"1","author":"Ehrlich, P.; Lazarus, A.","year":"1910","unstructured":"Ehrlich, P., and Lazarus, A. (1910). Anaemia, translated by H. W. Armit, 2nd ed., Pt. 1, Vol. 1, pp. 69-70. Rebman, London.","edition":"2nd ed"},{"key":"ref_5","first-page":"883","article-title":"Maladie de biermer a forme hepatom6galique avec pigmentation, simulant une cirrhose pigmentaire","volume":"12","author":"Harvier, P.; Mallarme, J.","year":"1968","unstructured":"Harvier, P., and Mallarme, J. (1968). Maladie de biermer a forme hepatom6galique avec pigmentation, simulant une cirrhose pigmentaire. Sang, 12, 883-886.","journal-title":"Sang"},{"key":"ref_6","first-page":"1","volume-title":"The megaloblastic anaemias. In Recent Advances in Haematology","author":"Hoffbrand, A.V.","year":"1971","unstructured":"Hoffbrand, A. V. (1971). The megaloblastic anaemias. In Recent Advances in Haematology, edited by A. Goldberg and M. C. Brian, pp. 1-76. Churchill Livingstone, and Edinburgh London."},{"key":"ref_7","first-page":"375","article-title":"Dysplastic anaemias","volume":"12","author":"Lewis, S.M.","year":"1972","unstructured":"Lewis, S. M. (1972). Dysplastic anaemias. Nouv. rev. franC. Hemat., 12, 375-383.","journal-title":"Nouv. rev. franC. Hemat"},{"key":"ref_8","first-page":"99","article-title":"Dyserythropoiesis and dyserythropoietic anemia","volume":"8","author":"Lewis, S.M.; Verwilghen, R.L.","year":"1974","unstructured":"Lewis, S. M., and Verwilghen, R. L. (1974). Dyserythropoiesis and dyserythropoietic anemia. Progr. Hemat., 8, 99-129.","journal-title":"Progr. Hemat"},{"key":"ref_9","first-page":"127","article-title":"An undescribed type of erythropoiesis observed in human sternal marrow","volume":"36","author":"Limarzi, L.R.; Levinson, S.A.","year":"1943","unstructured":"Limarzi, L. R., and Levinson, S. A. (1943). An undescribed type of erythropoiesis observed in human sternal marrow. Arch. Path., 36, 127-143.","journal-title":"Arch. Path"},{"key":"ref_10","first-page":"389","article-title":"Multipolar giant erythroblastosis","volume":"24","author":"Lonser, E.R.; Hadley, G.G.","year":"1955","unstructured":"Lonser, E. R., and Hadley, G. G. (1955). Multipolar giant erythroblastosis (A second observation). Rev. belge Path., 24, 389-394.","journal-title":"Rev. belge Path"},{"key":"ref_11","first-page":"127","article-title":"Giant orthochromatic erythroblasts","volume":"29","author":"Schleicher, E.M.","year":"1944","unstructured":"Schleicher, E. M. (1944). Giant orthochromatic erythroblasts. J. Lab. cdin. Med., 29, 127-133.","journal-title":"J. Lab. cdin. 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