{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:03:27Z","timestamp":1765724607991,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,5]]},"abstract":"<jats:p>A comparison of the indirect haemagglutination test (IHAT) with the dye test (DT) in 23 infants with congenital toxoplasmosis showed that in the early part of the first year of life the IHAT titres were nearly all lower than the DT titres. In six cases the IHAT was negative or the titre was so low that the cases could have been missed in routine screening. Later in the first year the IHAT titres became higher than the DT and remained so. The infants belonging to mothers with a high IHAT and therefore assumed to have become infected early in pregnancy had severe infections which included all the cases of hydrocephalus. Infants of mothers with low IHAT titres relative to the DT and therefore thought to have been infected later in pregnancy had generalized, mild or subclinical infection. With some difficulty a suitable commercial conjugated anti-IgM serum was found that gave positive results in immunofluorescent antibody tests for specific IgM antibody with all the infected infants and their mothers throughout the first year and negative results in uninfected infants and their mothers.<\/jats:p>","DOI":"10.1136\/jcp.28.5.383","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"383-387","source":"Crossref","is-referenced-by-count":8,"title":["Serological diagnosis of congenital toxoplasmosis."],"prefix":"10.1136","volume":"28","author":[{"given":"K A","family":"Karim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G B","family":"Ludlam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1056\/NEJM197405162902003","article-title":"Congenital toxoplasmosis: a prospective study of 378 pregnancies","volume":"290","author":"Desmonts, G.; Couvreur, J.","year":"1974","unstructured":"Desmonts, G. and Couvreur, J. (1974a). Congenital toxoplasmosis: a prospective study of 378 pregnancies. New Engl. J. Med., 290, 1110-1116.","journal-title":"New Engl. J. Med"},{"key":"ref_2","first-page":"146","article-title":"Toxoplasmosis in pregnancy and its transmission to the fetus","volume":"50","author":"Desmonts, G.; Couvreur, J.","year":"1974","unstructured":"Desmonts, G. and Couvreur, J. (1974b). Toxoplasmosis in pregnancy and its transmission to the fetus. Bull. N. Y. Acad. Med., 50, 146-159.","journal-title":"Bull. N. Y. Acad. Med"},{"key":"ref_3","first-page":"41","article-title":"A study of congenital toxoplasmosis","author":"Eichenwald, H.F.","year":"1959","unstructured":"Eichenwald, H. F. (1959). A study of congenital toxoplasmosis. In Human Toxoplasmosis, edited by J. C. Siim, pp. 41-49. Munksgaard, Copenhagen."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/jcp.28.1.42","article-title":"The relationship and significance of antibody titres as determined by various serological methods in glandular and ocular toxoplasmosis","volume":"28","author":"Karim, K.A.; Ludlam, G.B.","year":"1975","unstructured":"Karim, K. A. and Ludlam, G. B. (1975). The relationship and significance of antibody titres as determined by various serological methods in glandular and ocular toxoplasmosis. J. clin. Path., 28, 42-49.","journal-title":"J. clin. Path"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0022-3476(69)80385-9","article-title":"Quantitation of cord serum IgM and IgA as a screening procedure to detect congenital infection: results in 5,006 infants","volume":"75","author":"Miller, M.J.; Sunshine, P.J.; Remington, J.S.","year":"1969","unstructured":"Miller, M. J., Sunshine, P. J., and Remington, J. S. (1969). Quantitation of cord serum IgM and IgA as a screening procedure to detect congenital infection: results in 5,006 infants. J. Pediat., 75, 1287-1291.","journal-title":"J. Pediat"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0022-3476(73)80307-5","article-title":"Congenital toxoplasmosis: variability in the IgM-fluorescent antibody response and some pitfalls in diagnosis","volume":"83","author":"Remington, J.S.; Desmonts, G.","year":"1973","unstructured":"Remington, J. S. and Desmonts, G. (1973). Congenital toxoplasmosis: variability in the IgM-fluorescent antibody response and some pitfalls in diagnosis. J. Pediat., 83, 27-30.","journal-title":"J. Pediat"},{"key":"ref_7","first-page":"1082","article-title":"IgM antibodies in acute toxoplasmosis. I. Diagnostic significance in congenital cases and a method for their rapid demonstration","volume":"41","year":"1968","unstructured":"Remington, J. S., Miller, M. J., and Brownlee, 1. (1968a). IgM antibodies in acute toxoplasmosis. I. Diagnostic significance in congenital cases and a method for their rapid demonstration. Pediatrics, 41, 1082-1091.","journal-title":"Pediatrics"},{"article-title":"IgM antibodies in acute toxoplasmosis","year":"1968","key":"ref_8","unstructured":"Remington, J. S., Miller, M. J., and Brownlee, 1. (1968b) IgM antibodies in acute toxoplasmosis."},{"key":"ref_9","first-page":"855866","article-title":"Prevalence and significance in acquired cases","volume":"71","author":"Sabin, A.B.; Eichenwald, H.; Feldman, H.A.; Jacobs, L.","year":"1952","unstructured":"Prevalence and significance in acquired cases. J. Lab. clin. Med., 71, 855866. Sabin, A. B., Eichenwald, H., Feldman, H. A., and Jacobs, L. (1952). Present status of clinical manifestations of toxoplasmosis in man: indications and provisions for routine serological diagnosis. J. Amer. med. Ass., 150, 1063-1069.","journal-title":"J. Lab. clin. Med; Present status of clinical manifestations of toxoplasmosis in man: indications and provisions for routine serological diagnosis"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.28.5.383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T14:58:32Z","timestamp":1765724312000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.28.5.383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,5]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1975,5,1]]},"published-print":{"date-parts":[[1975,5]]}},"alternative-id":["10.1136\/jcp.28.5.383"],"URL":"https:\/\/doi.org\/10.1136\/jcp.28.5.383","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1975,5]]}}}