{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T09:09:05Z","timestamp":1765012145743,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1975,9]]},"abstract":"<jats:p>Attendances at the Regional Haemophilia Reference Centre in the Edinburgh Royal Infirmary have been analysed over a period of five years from 1969 to 1973. Of 77 patients registered in 1969, 64 had haemophilia A (factor VIII deficiency) and 13 had haemophilia B (factor IX deficiency). In 1973 the numbers were 68 and 14 respectively. An increased attendance at the Centre from 123 in 1969 to 624 in 1973 was noted. This was due to patients reporting earlier and more frequently for outpatient treatment of haemarthroses which occurred with the greater availability of supplies of factor VIII. The number of admissions for inpatient treatment did not change significantly over the period. Haemarthrosis of the knee was the commonest dominant lesion. The amount of replacement therapy in the form of fresh frozen plasma, cryoprecipitate, antihaemophilic fraction, and factors II, IX, and X concentrate used in the Centre (ie, excluding that used for elective procedures) increased from 2704 donor units in 1969 to 8778 donor units in 1973, the main increase being in cryoprecipitate. The number of factor VIII units used per patient attending per year, for both elective and emergency treatment in haemophiliacs, is recorded and discussed as are its effects on the treatment patterns of patients and the implications for the future.<\/jats:p>","DOI":"10.1136\/jcp.28.9.696","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"696-700","source":"Crossref","is-referenced-by-count":7,"title":["A five-year study of a haemophilia reference centre."],"prefix":"10.1136","volume":"28","author":[{"given":"D M","family":"Ramsay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K K","family":"Khoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,9,1]]},"reference":[{"key":"ref_1","article-title":"Personal communication","author":"Biggs, R.","year":"1974","unstructured":"Biggs, R. (1974). Personal communication."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1136\/bmj.2.5549.440","article-title":"Treatment of haemophilia","volume":"2","author":"Dalrymple-Champneys, W.; Hunter, J.R.; Polton, K.R.","year":"1967","unstructured":"Dalrymple-Champneys, W., Hunter, J. R., and Polton, K. R. (1967). Treatment of haemophilia. Brit. med. J., 2, 440.","journal-title":"Brit. med. J"},{"key":"ref_3","first-page":"105","article-title":"Hemophilia: current concepts in management","volume":"56","author":"Green, D.; Smith, N.J.","year":"1972","unstructured":"Green, D. and Smith, N. J. (1972). Hemophilia: current concepts in management. Med. Clin. N. Amer., 56, 105-117. Department of Health and Social Security (1968). Arrangements for the Care of Persons suffering from Haemophilia and Related Diseases. H.M. (68) 8, London.","journal-title":"Med. Clin. N. Amer; Arrangements for the Care of Persons suffering from Haemophilia and Related Diseases"},{"key":"ref_4","first-page":"1","volume-title":"Treatment of Haemophilia and Other Coagulation Disorders","author":"MacFarlane, R.G.","year":"1966","unstructured":"MacFarlane, R. G. (1966). In Treatment of Haemophilia and Other Coagulation Disorders, edited by R. Biggs and R. G. MacFarlane, p. 1. Blackwell Scientific Publications, Oxford."},{"key":"ref_5","first-page":"324","volume-title":"Treatment of Haemophilia and Other Coagulation Disorders","author":"MacFarlane, R.G.; Biggs, R.","year":"1966","unstructured":"MacFarlane, R. G. and Biggs, R. (1966). In Treatment of Haemophilia and Other Coagulation Disorders, edited by R. Biggs and R. G. MacFarlane, p. 324. Blackwell Scientific Publications, Oxford."},{"key":"ref_6","article-title":"Haemophilia and its related conditions: a brief guide to diagnosis and treatment. Memor","volume":"44","author":"Biggs, R.","year":"1974","unstructured":"Biggs, R. (1974). Haemophilia and its related conditions: a brief guide to diagnosis and treatment. Memor. med. Res. Coun. (Lond.), No. 44, iii.","journal-title":"med. Res. Coun. (Lond.)"},{"key":"ref_7","first-page":"763","article-title":"The management of haemophilia","volume":"204","author":"Rizza, C.R.","year":"1970","unstructured":"Rizza, C. R. (1970). The management of haemophilia. The Practitioner, 204, 763-772.","journal-title":"The Practitioner"},{"key":"ref_8","first-page":"343","volume":"6","author":"Rizza, C.R.; Biggs, R.","year":"1971","unstructured":"Rizza, C. R. and Biggs, R. (1971). Haemophilia today. Brit. J. Hosp. Med., 6, 343-356.","journal-title":"Haemophilia today. Brit. J. Hosp. Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1136\/bmj.2.5530.1624","article-title":"Haemorrhagic episodes in haemophilia: a five year prospective study","volume":"2","author":"Stuart, J.; Davies, S.H.; Cumming, R.A.; Girdwood, R.H.; Darg, A.","year":"1966","unstructured":"Stuart, J., Davies, S. H., Cumming, R. A., Girdwood, R. H., and Darg, A. (1966). Haemorrhagic episodes in haemophilia: a five year prospective study. Brit. med. J., 2, 1624-1626.","journal-title":"Brit. med. J"},{"key":"ref_10","first-page":"279","volume-title":"Treatment of Haemophilia and Other Coagulation Disorders","author":"Trueta, J.","year":"1966","unstructured":"Trueta, J. (1966). In Treatment of Haemophilia and Other Coagulation Disorders, edited by R. Biggs and R. G. MacFarlane, p. 279. Blackwell Scientific Publications, Oxford."},{"key":"ref_11","unstructured":"Although the number of cryoprecipitate packs used for outpatients at the Centre rose from 4273 in 1973 to 4603 in 1974, the amounts of cryoprecipitate and AHF used for inpatient treatment, including elective operations, fell by an amount equivalent to 1950 donor units so that the total donor units used in 1974 was 9304 as compared with 10 504 in 1973. The predicted rise in total donor units required in 1974, as shown in fig 1, has not been borne out, and this may signify a lessening of increase in demand for replacement therapy.","article-title":"Although the number of cryoprecipitate packs used for outpatients at the Centre rose from 4273 in 1973 to 4603 in 1974, the amounts of cryoprecipitate and AHF used for inpatient treatment, including elective operations, fell by an amount equivalent to 1950 donor units so that the total donor units used in 1974 was 9304 as compared with 10 504 in 1973. The predicted rise in total donor units required in 1974, as shown in fig 1, has not been borne out, and this may signify a lessening of increase in demand for replacement therapy"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.28.9.696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T09:05:41Z","timestamp":1765011941000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.28.9.696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,9]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1975,9,1]]},"published-print":{"date-parts":[[1975,9]]}},"alternative-id":["10.1136\/jcp.28.9.696"],"URL":"https:\/\/doi.org\/10.1136\/jcp.28.9.696","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1975,9]]}}}