{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:31:47Z","timestamp":1759048307859,"version":"3.44.0"},"reference-count":28,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1976,12]]},"abstract":"<jats:p>A description has been given of cerebrospinal fluid (CSF) immunoglobulins in 355 patients with demyelinating, infectious, neuropathic, and other neurological disorders. An increase in the CSF IgG\/albumin quotient was observed in 19\/36 (53%) cases of definite multiple sclerosis (MS), in 13\/47 (28%) cases of probable or possible MS, in 6\/9 (67%) cases of proven herpes simplex viral encephalitis (HSVE), in 3\/4 (75%) cases of neurosyphilis, in 1\/1 case of subacute sclerosing panencephalitis (SSPE), in 2\/9 )22%) cases of other central nervous system infections, and in 2\/12 (17%) cases of polyneuritis when compared with a group of 236 patients having other neurological disorders. In constrast, a relative increase in the CSF IgA of IgM was seen only in some of the patients with central nervous system infections. It was also found that the quotient CSF\/serum IgG, expressed as a percentage of the CSF\/serum albumin, was better in distinguishing patients with definite or suspected MS from those with other neurological disorders than the quotients IgG\/albumin or IgG\/total protein. The CSF K\/lambda ratio and the CSF and serum complement-fixing antibody titre to measles and herpes simplex virus were measured in many of the patients. In general, abnormalities of these measurements were associated with raised IgG\/albumin quotients. However, in eight patients with definite or suspected MS, a normal IgG\/albumin quotient was found with abnormal CSF K\/lambda ratios (6 cases) or abnormal CSF titres of measles antibody (7 cases). In addition, two patients, with HSVE had normal IgG\/albumin ratios but detectable herpes antibody in the CSF. These findings suggest that the measurement of the relative concentration of CSF immunoglobulin in combination with the K\/lambda ratio and antibody titre to various viruses may supplement each other in the endeavour to detect central nervous system immunglobulin sysnthesis in neurological diseases.<\/jats:p>","DOI":"10.1136\/jcp.29.12.1105","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1105-1115","source":"Crossref","is-referenced-by-count":25,"title":["Cerebrospinal fluid immunoglobulin quotients, kappa\/lambda ratios, and viral antibody titres in neurological disease."],"prefix":"10.1136","volume":"29","author":[{"given":"P J","family":"Roberts-Thomson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Esiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I C","family":"Maclennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1976,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3181\/00379727-111-27855","article-title":"Measles virus antibodies in multiple sclerosis","volume":"111","author":"Adams, J.M.; Imagawa, D.T.","year":"1962","unstructured":"Adams, J. 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