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Our study shows that if diagnosis is based solely on the light microscope appearances of renal biopsy, diseases other than minimal change are likely to be overlooked. Accuracy of diagnosis in structural terms requires additional immunofluorescence and electron microscopic study; final clinical diagnosis also requires careful follow-up, and repeat biopsy may be necessary.<\/jats:p>","DOI":"10.1136\/jcp.29.5.380","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"380-397","source":"Crossref","is-referenced-by-count":5,"title":["Diseases and histological normality of the renal glomerulus: a clinicopathological study."],"prefix":"10.1136","volume":"29","author":[{"given":"W","family":"Lawler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Tarpey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J","family":"Acheson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N P","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1976,5,1]]},"reference":[{"key":"ref_1","first-page":"959","article-title":"Controlled trial of azathioprine in children with nephrotic syndrome","volume":"1","author":"Abramowicz, M.; Barnett, H.L.; Edelmann, Jr., C.M.; Greifer, I.; Kobayashi, O.; Arneil, G.C.; Barron, B.A.; Gordillo-P., G.; Hallman, N.; Tiddens, H.A.","year":"1970","unstructured":"Abramowicz, M., Barnett, H. 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Focal glomerulosclerosis","volume":"2","author":"Lancet","year":"1972","unstructured":"Lancet (1972). Leading article. Focal glomerulosclerosis. Lancet, 2, 367.","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0140-6736(73)91729-7","article-title":"Glomerular localisation of IgE in lipoid nephrosis","volume":"1","author":"Lewis, E.J.; Kallen, R.J.; Rowe, D.S.","year":"1973","unstructured":"Lewis, E. J., Kallen, R. J., and Rowe, D. S. (1973). Glomerular localisation of IgE in lipoid nephrosis. (Letter). Lancet, 1, 1395.","journal-title":"(Letter). Lancet"},{"key":"ref_26","first-page":"111","volume-title":"Electron microscopy in the classification of glomerulonephritis. In Glomerulonephritis: Morphology, Natural History","author":"MacDonald, M.K.","year":"1973","unstructured":"MacDonald, M. K. (1973). Electron microscopy in the classification of glomerulonephritis. 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Amer"},{"key":"ref_29","first-page":"81","volume-title":"The value of immunofluorescence in the diagnosis of glomerulonephritis not related to systemic diseases. In Glomerulonephritis: Morphology, Natural History","volume":"1","author":"Morel-Maroger, L.; Adam, C.; Richet, G.","year":"1973","unstructured":"Morel-Maroger, L., Adam, C., and Richet, G. (1973). The value of immunofluorescence in the diagnosis of glomerulonephritis not related to systemic diseases. In Glomerulonephritis: Morphology, Natural History, and Treatment, edited by P. Kincaid-Smith, T. H. Mathew, and E. L. Becker, Part 1, pp.81-110."},{"key":"ref_30","first-page":"53","article-title":"Glomerular abnormalities in nonsystemic diseases","author":"Wiley, New York Morel-Maroger; L., Leathem; A.; Richet, G.","year":"1972","unstructured":"Wiley, New York. Morel-Maroger, L., Leathem, A., and Richet, G. (1972). Glomerular abnormalities in nonsystemic diseases. Amer. J. Med., 53,170-184.","journal-title":"Amer. J. Med"},{"key":"ref_31","first-page":"109127","article-title":"The fine structure of the glomerulus in membranous glomerulonephritis (lipoid nephrosis) in adults","volume":"32","author":"Movat, H.Z.; McGregor, D.D.","year":"1959","unstructured":"Movat, H. Z. and McGregor, D. D. (1959). The fine structure of the glomerulus in membranous glomerulonephritis (lipoid nephrosis) in adults. Amer. J. clin. Path., 32, 109127.","journal-title":"Amer. J. clin. Path"},{"key":"ref_32","first-page":"128","article-title":"Renal biopsy: an adjunct in the study of kidney disease","author":"Muehrcke, R.C.; Pirani, C.L.","year":"1972","unstructured":"Muehrcke, R. C. and Pirani, C. L. (1972). Renal biopsy: an adjunct in the study of kidney disease. In Renal Disease, edited by D. A. K. Black, 3rd edition, p. 128. 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Med"},{"key":"ref_38","first-page":"155","volume-title":"The value of electron microscopy in the study of glomerular disease. In Renal Disease","author":"Spargo, B.H.; Seymour, A.E.","year":"1972","unstructured":"Spargo, B. H. and Seymour, A. E. (1972). The value of electron microscopy in the study of glomerular disease. In Renal Disease, edited by D. A. K. Black, pp. 155-186. Blackwell, Oxford."},{"key":"ref_39","first-page":"1353","article-title":"Clinicopathological study of the nephrotic syndrome in childhood","volume":"1","author":"White, R.H.R.; Glasgow, E.F.; Mills, R.J.","year":"1970","unstructured":"White, R. H. R., Glasgow, E. F., and Mills, R. J. (1970). Clinicopathological study of the nephrotic syndrome in childhood. 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